HIPHOP chemogenomics database

YCL021W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL021W-A / YCL021W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YCL021W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1687	st020778	8.56	55.4 µM	9.80E-22		59	5.64E-18
2	SGTC_351	caspofungin	8.45	25.0 nM	3.30E-21	cell wall	14	1.51E-17
3	SGTC_58	0957-0393	5.93	9.0 µM	2.34E-11	cell wall	218	1.55E-9
4	SGTC_1712	st032288	5.55	53.4 µM	3.56E-10	calcium & mitochondrial duress	89	1.42E-8
5	SGTC_2688	kanamycin b	5.46	96.7 µM	6.81E-10	calcium & mitochondrial duress	199	2.42E-8
6	SGTC_2316	5844804	4.94	197.4 µM	2.02E-8		9	3.84E-7
7	SGTC_1597	7-benzyloxygramine	4.64	47.5 µM	1.32E-7	calcium & mitochondrial duress	80	1.78E-6
8	SGTC_2983	9022671	4.19	13.0 µM	1.66E-6	60S ribosome export	8	1.40E-5
9	SGTC_1736	st036774	3.98	51.0 µM	5.07E-6		32	3.51E-5
10	SGTC_56	0957-0365	3.78	83.2 µM	1.36E-5	Golgi	53	7.88E-5
11	SGTC_2021	4019055	3.64	173.0 µM	2.62E-5	endomembrane recycling	143	1.35E-4
12	SGTC_1716	st033144	3.53	30.6 µM	4.48E-5		32	2.09E-4
13	SGTC_1745	st081495	3.52	74.0 µM	4.59E-5	RNA processing & uracil transport	92	2.13E-4
14	SGTC_308	4092-1169	3.44	104.0 µM	6.66E-5	plasma membrane duress	71	2.89E-4
15	SGTC_751	0833-0568	3.42	350.0 µM	7.40E-5		41	3.15E-4
16	SGTC_698	k064-0052	3.27	127.0 µM	1.39E-4	DNA damage response	9	5.31E-4
17	SGTC_640	3381-0960	3.22	37.1 µM	1.75E-4		39	6.40E-4
18	SGTC_1748	st037455	3.19	53.6 µM	2.00E-4		71	7.13E-4
19	SGTC_2976	9009005	3.11	19.5 µM	2.84E-4		61	9.51E-4
20	SGTC_146	3448-8650	3.05	53.1 µM	3.49E-4	NEO1-PIK1	215	0.00113

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.290	3.63E-66	YGL203C	KEX1	hom	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.283	5.82E-63	YKL051W	SFK1	hom	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.230	1.63E-41	YNL288W	CAF40	hom	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.228	1.10E-40	YKL076C_d	PSY1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.213	1.13E-35	YLR330W	CHS5	hom	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.210	1.22E-34	YIL105C	SLM1	hom	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.201	5.11E-32	YDL213C	NOP6	hom	rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.196	2.66E-30	YGR058W	PEF1	hom	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.194	1.00E-29	YLR408C_p	BLS1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.192	4.05E-29	YJR142W_p	YJR142W_p	hom	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.190	1.51E-28	YDR467C_d	YDR467C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.188	6.19E-28	YML001W	YPT7	hom	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.187	9.88E-28	YDR335W	MSN5	hom	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.185	2.38E-27	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.184	8.81E-27	YJL165C	HAL5	hom	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication