HIPHOP chemogenomics database

YCL024W / KCC4

Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL024W / KCC4

Click on Significant Values for Screen Details

Top fitness defect scores for YCL024W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2772	vinpocetine	6.60	57.1 µM	1.11E-11		3	2.04E-11
2	SGTC_1742	st038235	6.13	28.9 µM	2.64E-10	mitochondrial stress	43	4.45E-10
3	SGTC_1407	3909-7909	5.73	12.3 µM	3.11E-9	60S ribosome export	2	4.91E-9
4	SGTC_3205	9113483	5.07	49.5 µM	1.39E-7		7	1.99E-7
5	SGTC_2764	methyldopa	4.95	94.7 µM	2.64E-7		9	3.70E-7
6	SGTC_2130	NSC 7	4.59	2.5 µM	1.62E-6	copper-dependent oxidative stress	13	2.17E-6
7	SGTC_1898	st060199	4.25	18.6 µM	8.25E-6		8	1.06E-5
8	SGTC_1871	st057448	4.15	67.3 µM	1.30E-5		20	1.64E-5
9	SGTC_2474	5321570	4.14	43.3 µM	1.35E-5		8	1.71E-5
10	SGTC_1650	st011916	3.95	45.8 µM	3.12E-5		15	3.86E-5
11	SGTC_1634	st006576	3.67	41.0 µM	1.02E-4	TSC3-RPN4	28	1.22E-4
12	SGTC_12	0849-0099	3.59	9.3 µM	1.39E-4		29	1.66E-4
13	SGTC_2950	9072895	3.44	21.5 µM	2.52E-4		63	2.96E-4
14	SGTC_2423	st077119	3.39	87.2 µM	3.00E-4		27	3.51E-4
15	SGTC_3291	9121177	3.37	71.4 µM	3.27E-4		26	3.81E-4
16	SGTC_2004	4023728	3.28	41.9 µM	4.57E-4		57	5.28E-4
17	SGTC_944	3370-0224	3.25	231.0 µM	4.93E-4		54	5.68E-4
18	SGTC_728	3030-5151	3.23	22.5 µM	5.46E-4		32	6.28E-4
19	SGTC_1781	st038725	3.19	66.3 µM	6.25E-4	NEO1	147	7.17E-4
20	SGTC_2778	tioconazole	3.18	65.1 nM	6.46E-4	ergosterol depletion effects on membrane	105	7.40E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.123	7.44E-13	YER183C	FAU1	hom	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.121	2.26E-12	YOL028C	YAP7	hom	Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.115	2.20E-11	YIL168W	YIL168W	hom	Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase
0.109	2.69E-10	YPL164C	MLH3	hom	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.103	1.97E-9	YER001W	MNN1	hom	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.101	4.39E-9	YGL061C	DUO1	het	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.100	6.62E-9	YOL147C	PEX11	hom	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.096	2.16E-8	YBR204C	LDH1	hom	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.093	6.75E-8	YKL169C_d	YKL169C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
0.089	2.35E-7	YDR527W	RBA50	het	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.087	4.43E-7	YKL034W	TUL1	hom	Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.086	5.40E-7	YJR057W	CDC8	het	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
0.086	6.37E-7	YKR027W	BCH2	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.085	8.18E-7	YIL093C	RSM25	hom	Mitochondrial ribosomal protein of the small subunit
0.083	1.68E-6	YJL136C	RPS21B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication