YCL026C-B / HBN1

Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL026C-B / HBN1

Click on Significant Values for Screen Details

Top fitness defect scores for YCL026C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_940 3232-1287 5.42 54.8 µM 1.16E-7 NEO1 11 2.95E-8
2 SGTC_2803 7707263 5.38 71.4 µM 1.41E-7 12 3.67E-8
3 SGTC_2941 9056145 4.92 11.2 µM 1.37E-6 9 4.41E-7
4 SGTC_3174 9107204 4.66 49.5 µM 4.47E-6 ERG2 16 1.61E-6
5 SGTC_1011 4112-3381 4.58 17.4 µM 6.34E-6 24 2.36E-6
6 SGTC_661 1304-0007 4.30 33.6 µM 2.04E-5 16 8.47E-6
7 SGTC_3200 9114385 3.91 49.5 µM 9.67E-5 37 4.64E-5
8 SGTC_3196 9111891 3.89 49.5 µM 1.02E-4 mitochondrial processes 16 4.94E-5
9 SGTC_2264 7948757 3.86 110.8 µM 1.15E-4 15 5.62E-5
10 SGTC_3185 9108267 3.84 49.5 µM 1.27E-4 60S ribosome export 20 6.25E-5
11 SGTC_3164 9100705 3.77 49.5 µM 1.60E-4 6 8.04E-5
12 SGTC_1938 st074717 3.77 56.4 µM 1.64E-4 15 8.27E-5
13 SGTC_719 2810-4230 3.74 27.3 µM 1.78E-4 9 9.03E-5
14 SGTC_3170 9103054 3.70 49.5 µM 2.06E-4 60S ribosome export 16 1.06E-4
15 SGTC_1592 4',5'-dihydroxyflavone 3.70 8.8 µM 2.08E-4 60S ribosome export 19 1.07E-4
16 SGTC_2678 equilin 3.68 100.0 µM 2.23E-4 26 1.15E-4
17 SGTC_2053 5265679 3.65 138.0 µM 2.48E-4 32 1.30E-4
18 SGTC_2943 9068529 3.62 45.3 µM 2.81E-4 28 1.49E-4
19 SGTC_993 3909-8757 3.61 62.7 µM 2.88E-4 33 1.53E-4
20 SGTC_2054 5233173 3.58 129.0 µM 3.26E-4 mitochondrial response to ROS 71 1.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.085 9.06E-7 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.083 1.35E-6 YLR236C_d YLR236C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.18E-6 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.077 8.89E-6 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.076 1.17E-5 YOL075C_p YOL075C_p hom Putative ABC transporter
0.071 4.22E-5 YMR158C-A_p YMR158C-A_p hom Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene
0.070 5.03E-5 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.070 5.24E-5 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.069 6.78E-5 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.068 7.43E-5 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.068 7.64E-5 YOR175C ALE1 hom Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
0.068 9.00E-5 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.067 1.03E-4 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.066 1.27E-4 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.066 1.43E-4 YPR109W_p YPR109W_p hom Predicted membrane protein; dipoid deletion strain has high budding index