YCL028W / RNQ1

[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL028W / RNQ1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.90|P-value:1.56E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.61|P-value:5.18E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.32|P-value:1.71E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.35|P-value:1.57E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.85|P-value:1.68E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.04|P-value:6.91E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:3.50|P-value:8.32E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.09|P-value:4.33E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.03|P-value:5.56E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.03|P-value:6.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.94|P-value:7.60E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.25|P-value:2.35E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.85|P-value:1.70E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.38|P-value:1.34E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.80|P-value:2.11E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.03|P-value:5.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.14|P-value:3.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.18|P-value:3.42E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.55|P-value:4.86E-7 ID:SGTC_2480|Compound:5767542|FD-Score:4.88|P-value:7.57E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.72|P-value:1.91E-7 ID:SGTC_2898|Compound:9056270|FD-Score:3.10|P-value:4.21E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.41|P-value:1.37E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.89|P-value:9.39E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.56|P-value:4.58E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.96|P-value:9.99E-6 ID:SGTC_3114|Compound:9122766|FD-Score:2.98|P-value:6.54E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.14|P-value:3.54E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.04|P-value:5.94E-4 ID:SGTC_3257|Compound:9139206|FD-Score:2.90|P-value:8.74E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.73|P-value:3.01E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.19|P-value:3.20E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.59|P-value:6.38E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.90|P-value:1.56E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.61|P-value:5.18E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.29|P-value:1.99E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.22|P-value:2.66E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.32|P-value:1.71E-6 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.35|P-value:1.57E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:3.85|P-value:1.68E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.21|P-value:2.72E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.04|P-value:6.91E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:3.50|P-value:8.32E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.09|P-value:4.33E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.03|P-value:5.56E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:2.96|P-value:7.02E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.03|P-value:6.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:2.94|P-value:7.60E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.25|P-value:2.35E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.85|P-value:1.70E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.38|P-value:1.34E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.80|P-value:2.11E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.03|P-value:5.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.14|P-value:3.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.18|P-value:3.42E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.20|P-value:2.82E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.55|P-value:4.86E-7 ID:SGTC_2480|Compound:5767542|FD-Score:4.88|P-value:7.57E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.72|P-value:1.91E-7 ID:SGTC_2898|Compound:9056270|FD-Score:3.10|P-value:4.21E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.41|P-value:1.37E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.89|P-value:9.39E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.56|P-value:4.58E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.96|P-value:9.99E-6 ID:SGTC_3114|Compound:9122766|FD-Score:2.98|P-value:6.54E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.14|P-value:3.54E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-3.04|P-value:5.94E-4 ID:SGTC_3257|Compound:9139206|FD-Score:2.90|P-value:8.74E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.73|P-value:3.01E-5 ID:SGTC_3316|Compound:9136639|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.19|P-value:3.20E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.59|P-value:6.38E-5

Top fitness defect scores for YCL028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2480 5767542 4.88 37.2 µM 7.57E-8 5 5.24E-7
2 SGTC_2482 5981709 4.72 142.7 µM 1.91E-7 PDR1 25 1.17E-6
3 SGTC_2963 9082507 4.56 9.0 µM 4.58E-7 15 2.51E-6
4 SGTC_2478 5763493 4.55 32.3 µM 4.86E-7 14 2.65E-6
5 SGTC_173 1273-0061 4.32 2.7 µM 1.71E-6 mitochondrial stress 173 7.92E-6
6 SGTC_3323 9138564 4.19 53.9 µM 3.20E-6 15 1.37E-5
7 SGTC_391 gliotoxin 4.04 8.3 µM 6.91E-6 56 2.68E-5
8 SGTC_3009 9080819 3.96 71.4 µM 9.99E-6 17 3.70E-5
9 SGTC_331 k048-0133 3.85 24.5 µM 1.68E-5 RSC & ERG11 12 5.83E-5
10 SGTC_1491 4138-0063 3.85 26.5 µM 1.70E-5 13 5.89E-5
11 SGTC_1854 st056233 3.80 32.9 µM 2.11E-5 amide catabolism 23 7.11E-5
12 SGTC_3314 9135860 3.73 59.4 µM 3.01E-5 24 9.68E-5
13 SGTC_136 0097-0015 3.61 404.5 µM 5.18E-5 60S ribosome export 29 1.55E-4
14 SGTC_583 1488-1091 3.50 88.9 µM 8.32E-5 31 2.35E-4
15 SGTC_3316 9136639 3.39 10.6 µM 1.30E-4 31 3.47E-4
16 SGTC_3322 9139058 3.39 2.1 µM 1.33E-4 cell wall 46 3.54E-4
17 SGTC_1503 4585-0012 3.38 61.3 µM 1.34E-4 35 3.57E-4
18 SGTC_272 doxorubicin 3.35 8.1 µM 1.57E-4 anthracycline transcription coupled DNA repair 45 4.09E-4
19 SGTC_140 0062-0056 3.29 502.5 µM 1.99E-4 45 5.03E-4
20 SGTC_250 brefeldin a 3.27 552.2 µM 2.17E-4 PDR1 33 5.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.39E-12 YPR095C SYT1 hom Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.114 3.13E-11 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.107 5.61E-10 YMR222C FSH2 hom Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2
0.098 1.36E-8 YBR018C GAL7 hom Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
0.098 1.45E-8 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.096 2.31E-8 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.091 1.38E-7 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.090 1.57E-7 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.087 4.29E-7 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.086 6.35E-7 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.086 6.34E-7 YDL003W MCD1 het Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
0.085 8.24E-7 YCL050C APA1 hom AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
0.085 8.42E-7 YDR507C GIN4 hom Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication
0.084 1.19E-6 YPL219W PCL8 hom Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
0.079 4.40E-6 YIL165C_p YIL165C_p hom Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene