YCL029C / BIK1

Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL029C / BIK1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:7.80|P-value:8.88E-15 ID:SGTC_37|Compound:0566-0070|FD-Score:5.79|P-value:6.57E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:5.19|P-value:1.73E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-7.41|P-value:1.35E-13 ID:SGTC_136|Compound:0097-0015|FD-Score:5.39|P-value:6.05E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:3.85|P-value:7.89E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.44|P-value:4.44E-8 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.56|P-value:2.32E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.33|P-value:8.21E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:4.97|P-value:5.18E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:4.15|P-value:2.28E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.36|P-value:9.30E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.32|P-value:1.12E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.79|P-value:8.89E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-5.63|P-value:1.34E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.43|P-value:3.84E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.74|P-value:1.61E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:-3.13|P-value:9.69E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.74|P-value:1.20E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.58|P-value:2.26E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.35|P-value:4.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.35|P-value:5.11E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.50|P-value:5.02E-6 ID:SGTC_1840|Compound:st055363|FD-Score:-3.17|P-value:8.59E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.47|P-value:1.00E-10 ID:SGTC_1927|Compound:st060202|FD-Score:-3.42|P-value:3.54E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.67|P-value:1.44E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.69|P-value:1.47E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.78|P-value:9.43E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.40|P-value:4.21E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.18|P-value:1.81E-7 ID:SGTC_2095|Compound:5432005|FD-Score:3.57|P-value:2.32E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.06|P-value:1.32E-9 ID:SGTC_2258|Compound:7960471|FD-Score:3.29|P-value:6.22E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.99|P-value:4.53E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.45|P-value:3.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.13|P-value:2.54E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.76|P-value:1.51E-11 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.84|P-value:7.37E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.51|P-value:2.88E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.89|P-value:6.69E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.31|P-value:5.85E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.80|P-value:8.88E-15 ID:SGTC_37|Compound:0566-0070|FD-Score:5.79|P-value:6.57E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:5.19|P-value:1.73E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-7.41|P-value:1.35E-13 ID:SGTC_136|Compound:0097-0015|FD-Score:5.39|P-value:6.05E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:3.85|P-value:7.89E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.44|P-value:4.44E-8 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:5.56|P-value:2.32E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.33|P-value:8.21E-8 ID:SGTC_344|Compound:k064-0035|FD-Score:4.97|P-value:5.18E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:4.15|P-value:2.28E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.36|P-value:9.30E-6 ID:SGTC_918|Compound:glabranin|FD-Score:4.32|P-value:1.12E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.79|P-value:8.89E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-5.63|P-value:1.34E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.43|P-value:3.84E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.74|P-value:1.61E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:-3.13|P-value:9.69E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.74|P-value:1.20E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.58|P-value:2.26E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.35|P-value:4.65E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.35|P-value:5.11E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.50|P-value:5.02E-6 ID:SGTC_1840|Compound:st055363|FD-Score:-3.17|P-value:8.59E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.47|P-value:1.00E-10 ID:SGTC_1927|Compound:st060202|FD-Score:-3.42|P-value:3.54E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.40|P-value:4.29E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.67|P-value:1.44E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.69|P-value:1.47E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.78|P-value:9.43E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.40|P-value:4.21E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.18|P-value:1.81E-7 ID:SGTC_2095|Compound:5432005|FD-Score:3.57|P-value:2.32E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.06|P-value:1.32E-9 ID:SGTC_2258|Compound:7960471|FD-Score:3.29|P-value:6.22E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.99|P-value:4.53E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.45|P-value:3.16E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.13|P-value:2.54E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.76|P-value:1.51E-11 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.84|P-value:7.37E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.51|P-value:2.88E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.89|P-value:6.69E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.31|P-value:5.85E-4

Top fitness defect scores for YCL029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_36 0335-0881 7.80 14.2 µM 8.88E-15 ubiquinone biosynthesis & proteasome 38 3.17E-15
2 SGTC_2690 usnic acid 6.76 100.0 µM 1.51E-11 4 6.84E-12
3 SGTC_1875 nocodazole 6.47 6.0 µM 1.00E-10 tubulin folding & SWR complex 25 4.83E-11
4 SGTC_2200 6600604 6.06 21.9 µM 1.32E-9 tubulin folding & SWR complex 28 6.88E-10
5 SGTC_37 0566-0070 5.79 1.6 µM 6.57E-9 7 3.62E-9
6 SGTC_240 5hr heat shock (37°C) + Streptovitacin 5.56 300.0 µM 2.32E-8 heat shock/prefoldin 20 1.33E-8
7 SGTC_229 benomyl 5.44 22.9 µM 4.44E-8 tubulin folding & SWR complex 19 2.60E-8
8 SGTC_136 0097-0015 5.39 404.5 µM 6.05E-8 60S ribosome export 3 3.58E-8
9 SGTC_241 5hr heat shock (37°C) + cantharidin 5.33 155.4 µM 8.21E-8 cell wall signaling 40 4.90E-8
10 SGTC_39 0986-0283 5.19 58.4 µM 1.73E-7 calcium & mitochondrial duress 14 1.06E-7
11 SGTC_2092 5303694 5.18 80.7 µM 1.81E-7 TSC3-RPN4 11 1.11E-7
12 SGTC_344 k064-0035 4.97 6.4 µM 5.18E-7 60S ribosome export 12 3.29E-7
13 SGTC_1326 1431-2094 4.74 10.8 µM 1.61E-6 tubulin folding & SWR complex 20 1.06E-6
14 SGTC_1829 berberine 4.50 14.4 µM 5.02E-6 60S ribosome export 11 3.43E-6
15 SGTC_916 4466-0038 4.36 42.0 nM 9.30E-6 cell wall 53 6.48E-6
16 SGTC_918 glabranin 4.32 770.7 nM 1.12E-5 21 7.85E-6
17 SGTC_866 0495-0101 4.15 262.0 µM 2.28E-5 60S ribosome export 14 1.63E-5
18 SGTC_2687 chenodiol 4.13 100.0 µM 2.54E-5 20 1.83E-5
19 SGTC_2268 7933382 3.99 153.8 µM 4.53E-5 37 3.33E-5
20 SGTC_3133 9127736 3.89 49.5 µM 6.69E-5 20 4.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.79E-30 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.191 7.90E-29 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.170 5.34E-23 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.169 8.02E-23 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.162 4.77E-21 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.156 8.58E-20 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.147 1.06E-17 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.145 3.42E-17 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.136 2.19E-15 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.135 5.01E-15 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.133 1.23E-14 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.130 4.59E-14 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.127 1.38E-13 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.125 3.37E-13 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.123 8.67E-13 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication