HIPHOP chemogenomics database

YCL029C / BIK1

Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL029C / BIK1

Click on Significant Values for Screen Details

Top fitness defect scores for YCL029C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_36	0335-0881	7.80	14.2 µM	8.88E-15	ubiquinone biosynthesis & proteasome	38	3.17E-15
2	SGTC_2690	usnic acid	6.76	100.0 µM	1.51E-11		4	6.84E-12
3	SGTC_1875	nocodazole	6.47	6.0 µM	1.00E-10	tubulin folding & SWR complex	25	4.83E-11
4	SGTC_2200	6600604	6.06	21.9 µM	1.32E-9	tubulin folding & SWR complex	28	6.88E-10
5	SGTC_37	0566-0070	5.79	1.6 µM	6.57E-9		7	3.62E-9
6	SGTC_240	5hr heat shock (37°C) + Streptovitacin	5.56	300.0 µM	2.32E-8	heat shock/prefoldin	20	1.33E-8
7	SGTC_229	benomyl	5.44	22.9 µM	4.44E-8	tubulin folding & SWR complex	19	2.60E-8
8	SGTC_136	0097-0015	5.39	404.5 µM	6.05E-8	60S ribosome export	3	3.58E-8
9	SGTC_241	5hr heat shock (37°C) + cantharidin	5.33	155.4 µM	8.21E-8	cell wall signaling	40	4.90E-8
10	SGTC_39	0986-0283	5.19	58.4 µM	1.73E-7	calcium & mitochondrial duress	14	1.06E-7
11	SGTC_2092	5303694	5.18	80.7 µM	1.81E-7	TSC3-RPN4	11	1.11E-7
12	SGTC_344	k064-0035	4.97	6.4 µM	5.18E-7	60S ribosome export	12	3.29E-7
13	SGTC_1326	1431-2094	4.74	10.8 µM	1.61E-6	tubulin folding & SWR complex	20	1.06E-6
14	SGTC_1829	berberine	4.50	14.4 µM	5.02E-6	60S ribosome export	11	3.43E-6
15	SGTC_916	4466-0038	4.36	42.0 nM	9.30E-6	cell wall	53	6.48E-6
16	SGTC_918	glabranin	4.32	770.7 nM	1.12E-5		21	7.85E-6
17	SGTC_866	0495-0101	4.15	262.0 µM	2.28E-5	60S ribosome export	14	1.63E-5
18	SGTC_2687	chenodiol	4.13	100.0 µM	2.54E-5		20	1.83E-5
19	SGTC_2268	7933382	3.99	153.8 µM	4.53E-5		37	3.33E-5
20	SGTC_3133	9127736	3.89	49.5 µM	6.69E-5		20	4.97E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.196	2.79E-30	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.191	7.90E-29	YGL094C	PAN2	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.170	5.34E-23	YML041C	VPS71	hom	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.169	8.02E-23	YOR349W	CIN1	hom	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.162	4.77E-21	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.156	8.58E-20	YLR085C	ARP6	hom	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.147	1.06E-17	YJL008C	CCT8	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.145	3.42E-17	YKL025C	PAN3	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.136	2.19E-15	YLR027C	AAT2	hom	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.135	5.01E-15	YDR212W	TCP1	het	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.133	1.23E-14	YBR231C	SWC5	hom	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.130	4.59E-14	YOL012C	HTZ1	hom	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.127	1.38E-13	YAL011W	SWC3	hom	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.125	3.37E-13	YDR485C	VPS72	hom	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.123	8.67E-13	YML124C	TUB3	hom	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication