YCL033C / MXR2

Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL033C / MXR2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-5.97|P-value:1.34E-10 ID:SGTC_52|Compound:0329-0193|FD-Score:-5.01|P-value:5.59E-8 ID:SGTC_194|Compound:1486-1323|FD-Score:3.68|P-value:5.15E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.52|P-value:1.03E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.58|P-value:7.82E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.29|P-value:2.63E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:2.94|P-value:9.77E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.69|P-value:4.91E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.32|P-value:2.29E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.63|P-value:6.44E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.08|P-value:5.71E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.14|P-value:4.57E-4 ID:SGTC_1769|Compound:st044406|FD-Score:2.96|P-value:8.91E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.59|P-value:7.08E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.04|P-value:6.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.80|P-value:3.06E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.28|P-value:2.94E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.60|P-value:6.96E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-3.65|P-value:5.56E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.06|P-value:5.84E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.05|P-value:6.34E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.10|P-value:5.04E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.46|P-value:1.26E-6 ID:SGTC_2200|Compound:6600604|FD-Score:-4.40|P-value:1.58E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:1.47E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.85|P-value:2.22E-5 ID:SGTC_2424|Compound:5537928|FD-Score:7.49|P-value:1.22E-15 ID:SGTC_2431|Compound:5490079|FD-Score:-3.13|P-value:4.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.79|P-value:3.11E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.52|P-value:8.33E-7 ID:SGTC_2952|Compound:9073731|FD-Score:5.37|P-value:7.12E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-5.74|P-value:6.32E-10 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-5.52|P-value:2.51E-9 ID:SGTC_2965|Compound:9082772|FD-Score:3.03|P-value:6.93E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.63|P-value:6.00E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.71|P-value:3.30E-7 ID:SGTC_3058|Compound:9093861|FD-Score:2.94|P-value:9.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.80|P-value:3.00E-5 ID:SGTC_3246|Compound:9135460|FD-Score:-2.97|P-value:8.28E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-5.97|P-value:1.34E-10 ID:SGTC_52|Compound:0329-0193|FD-Score:-5.01|P-value:5.59E-8 ID:SGTC_194|Compound:1486-1323|FD-Score:3.68|P-value:5.15E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.52|P-value:1.03E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.58|P-value:7.82E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.29|P-value:2.63E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:3.24|P-value:3.09E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:2.94|P-value:9.77E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.10|P-value:5.28E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.69|P-value:4.91E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.17|P-value:3.89E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.32|P-value:2.29E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.63|P-value:6.44E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.08|P-value:5.71E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.14|P-value:4.57E-4 ID:SGTC_1769|Compound:st044406|FD-Score:2.96|P-value:8.91E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.47|P-value:1.26E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.59|P-value:7.08E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.04|P-value:6.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.80|P-value:3.06E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.28|P-value:2.94E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.60|P-value:6.96E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-3.65|P-value:5.56E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-3.06|P-value:5.84E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.05|P-value:6.34E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.48|P-value:1.15E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.10|P-value:5.04E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.49|P-value:1.14E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.46|P-value:1.26E-6 ID:SGTC_2200|Compound:6600604|FD-Score:-4.40|P-value:1.58E-6 ID:SGTC_2295|Compound:7971645|FD-Score:3.43|P-value:1.47E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.85|P-value:2.22E-5 ID:SGTC_2424|Compound:5537928|FD-Score:7.49|P-value:1.22E-15 ID:SGTC_2431|Compound:5490079|FD-Score:-3.13|P-value:4.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.79|P-value:3.11E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-4.52|P-value:8.33E-7 ID:SGTC_2952|Compound:9073731|FD-Score:5.37|P-value:7.12E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-5.74|P-value:6.32E-10 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:1.80E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-5.52|P-value:2.51E-9 ID:SGTC_2965|Compound:9082772|FD-Score:3.03|P-value:6.93E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.63|P-value:6.00E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.21|P-value:3.56E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.71|P-value:3.30E-7 ID:SGTC_3058|Compound:9093861|FD-Score:2.94|P-value:9.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.80|P-value:3.00E-5 ID:SGTC_3246|Compound:9135460|FD-Score:-2.97|P-value:8.28E-4

Top fitness defect scores for YCL033C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2424 5537928 7.49 59.2 µM 1.22E-15 1 3.34E-14
2 SGTC_2952 9073731 5.37 13.8 µM 7.12E-9 tubulin folding & SWR complex 11 3.95E-8
3 SGTC_3050 9093513 4.71 49.5 µM 3.30E-7 8 1.24E-6
4 SGTC_2167 5876490 4.46 200.0 µM 1.26E-6 19 4.12E-6
5 SGTC_3232 9132874 3.80 49.5 µM 3.00E-5 RPP1 & pyrimidine depletion 18 7.19E-5
6 SGTC_1939 st074455 3.80 53.6 µM 3.06E-5 32 7.30E-5
7 SGTC_2908 7930301 3.79 100.0 µM 3.11E-5 31 7.43E-5
8 SGTC_1369 1866-0067 3.69 208.0 µM 4.91E-5 RPP1 & pyrimidine depletion 48 1.12E-4
9 SGTC_194 1486-1323 3.68 56.9 µM 5.15E-5 26 1.17E-4
10 SGTC_1621 st003705 3.63 32.4 µM 6.44E-5 calcium & mitochondrial duress 31 1.43E-4
11 SGTC_737 1950-0117 3.58 57.9 µM 7.82E-5 33 1.70E-4
12 SGTC_427 1354-0053 3.52 47.3 µM 1.03E-4 36 2.17E-4
13 SGTC_2155 5570423 3.49 76.0 µM 1.14E-4 ergosterol biosynthesis 18 2.39E-4
14 SGTC_1837 st055472 3.47 66.5 µM 1.26E-4 34 2.62E-4
15 SGTC_2295 7971645 3.43 200.0 µM 1.47E-4 42 3.00E-4
16 SGTC_1908 st060353 3.32 56.5 µM 2.26E-4 RPP1 & pyrimidine depletion 64 4.44E-4
17 SGTC_1612 st002233 3.32 45.4 µM 2.29E-4 36 4.48E-4
18 SGTC_753 1322-0200 3.29 289.0 µM 2.63E-4 44 5.09E-4
19 SGTC_826 1683-5028 3.24 118.0 µM 3.09E-4 33 5.88E-4
20 SGTC_3033 9090887 3.21 49.5 µM 3.56E-4 fatty acid desaturase (OLE1) 62 6.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.86E-9 YDL011C_d YDL011C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
0.101 4.60E-9 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.099 8.38E-9 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.097 1.94E-8 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.094 5.50E-8 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.094 5.73E-8 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.092 8.61E-8 YLR429W CRN1 hom Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
0.091 1.17E-7 YDR515W SLF1 hom RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.091 1.35E-7 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.087 5.21E-7 YCL057C-A MOS1 hom Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1
0.084 1.08E-6 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.083 1.73E-6 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.082 2.18E-6 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
0.080 3.61E-6 YCR031C RPS14A hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication
0.079 4.51E-6 YPL079W RPL21B hom Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication