YCL036W / GFD2

Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL036W / GFD2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.23|P-value:5.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.28|P-value:8.34E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:3.11|P-value:8.80E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.29|P-value:8.17E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.76|P-value:8.35E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.13|P-value:7.97E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.94|P-value:3.35E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.43|P-value:2.79E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.26|P-value:9.32E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:7.00|P-value:9.92E-13 ID:SGTC_1070|Compound:indatraline|FD-Score:3.36|P-value:3.69E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.29|P-value:4.70E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.50|P-value:2.15E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.41|P-value:2.92E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.91|P-value:4.30E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.60|P-value:1.48E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-4.67|P-value:1.23E-6 ID:SGTC_1743|Compound:st037606|FD-Score:4.29|P-value:8.18E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.15|P-value:7.88E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.75|P-value:8.36E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.30|P-value:4.61E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-4.34|P-value:6.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.62|P-value:1.29E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.21|P-value:5.96E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.18|P-value:6.96E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.05|P-value:1.91E-7 ID:SGTC_2260|Compound:7964312|FD-Score:3.82|P-value:6.18E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.24|P-value:5.47E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.54|P-value:2.55E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-4.67|P-value:1.23E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.11|P-value:1.72E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:6.35|P-value:8.42E-11 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.79|P-value:6.86E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.13|P-value:3.23E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.32|P-value:4.28E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.77|P-value:7.68E-5 ID:SGTC_3045|Compound:9092950|FD-Score:6.20|P-value:2.20E-10 ID:SGTC_3056|Compound:9094900|FD-Score:5.56|P-value:1.14E-8 ID:SGTC_3124|Compound:9127567|FD-Score:5.06|P-value:1.81E-7 ID:SGTC_3125|Compound:9127534|FD-Score:3.19|P-value:6.74E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.18|P-value:7.08E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.78|P-value:7.25E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.08|P-value:9.45E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.23|P-value:5.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.28|P-value:8.34E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:3.11|P-value:8.80E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.29|P-value:8.17E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.76|P-value:8.35E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.13|P-value:7.97E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.94|P-value:3.35E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.43|P-value:2.79E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.26|P-value:9.32E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:7.00|P-value:9.92E-13 ID:SGTC_1070|Compound:indatraline|FD-Score:3.36|P-value:3.69E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.29|P-value:4.70E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.50|P-value:2.15E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.41|P-value:2.92E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.91|P-value:4.30E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.60|P-value:1.48E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-4.67|P-value:1.23E-6 ID:SGTC_1743|Compound:st037606|FD-Score:4.29|P-value:8.18E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.15|P-value:7.88E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.75|P-value:8.36E-5 ID:SGTC_1801|Compound:st050089|FD-Score:3.30|P-value:4.61E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-4.34|P-value:6.02E-6 ID:SGTC_1871|Compound:st057448|FD-Score:-3.55|P-value:1.74E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_2004|Compound:4023728|FD-Score:4.21|P-value:1.18E-5 ID:SGTC_2058|Compound:5236698|FD-Score:-3.62|P-value:1.29E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.21|P-value:5.96E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.18|P-value:6.96E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.05|P-value:1.91E-7 ID:SGTC_2260|Compound:7964312|FD-Score:3.82|P-value:6.18E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.24|P-value:5.47E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.54|P-value:2.55E-6 ID:SGTC_2401|Compound:5128683|FD-Score:-4.67|P-value:1.23E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.11|P-value:1.72E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:6.35|P-value:8.42E-11 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.79|P-value:6.86E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.13|P-value:3.23E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.32|P-value:4.28E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.46|P-value:2.54E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.77|P-value:7.68E-5 ID:SGTC_3045|Compound:9092950|FD-Score:6.20|P-value:2.20E-10 ID:SGTC_3056|Compound:9094900|FD-Score:5.56|P-value:1.14E-8 ID:SGTC_3124|Compound:9127567|FD-Score:5.06|P-value:1.81E-7 ID:SGTC_3125|Compound:9127534|FD-Score:3.19|P-value:6.74E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.59|P-value:1.45E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.47|P-value:2.45E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.18|P-value:7.08E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.78|P-value:7.25E-5 ID:SGTC_3335|Compound:9143315|FD-Score:-3.08|P-value:9.45E-4

Top fitness defect scores for YCL036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1040 k898-0338 7.00 155.0 µM 9.92E-13 1 1.32E-12
2 SGTC_2407 paclitaxel 6.35 400.0 µM 8.42E-11 8 1.06E-10
3 SGTC_3045 9092950 6.20 49.5 µM 2.20E-10 2 2.74E-10
4 SGTC_3056 9094900 5.56 49.5 µM 1.14E-8 3 1.35E-8
5 SGTC_3124 9127567 5.06 49.5 µM 1.81E-7 DNA damage response 7 2.08E-7
6 SGTC_2249 haloperidol 5.05 116.4 µM 1.91E-7 ergosterol depletion effects on membrane 62 2.20E-7
7 SGTC_628 1636-0253 4.94 16.0 µM 3.35E-7 sphingolipid biosynthesis & PDR1 18 3.83E-7
8 SGTC_449 xestospongin c 4.76 11.2 µM 8.35E-7 NEO1-PIK1 38 9.45E-7
9 SGTC_2347 9049783 4.54 174.8 µM 2.55E-6 12 2.85E-6
10 SGTC_445 e6 berbamine 4.29 66.0 µM 8.17E-6 NEO1-PIK1 89 9.01E-6
11 SGTC_1743 st037606 4.29 46.4 µM 8.18E-6 16 9.03E-6
12 SGTC_87 0100-0052 4.28 35.5 µM 8.34E-6 87 9.20E-6
13 SGTC_939 1165-0479 4.26 45.3 µM 9.32E-6 20 1.03E-5
14 SGTC_2004 4023728 4.21 41.9 µM 1.18E-5 21 1.30E-5
15 SGTC_1941 st076221 4.06 61.8 µM 2.24E-5 sphingolipid biosynthesis & PDR1 75 2.45E-5
16 SGTC_1543 azetidyl-2-carboxylic acid 3.91 198.0 µM 4.30E-5 16 4.66E-5
17 SGTC_2260 7964312 3.82 200.0 µM 6.18E-5 16 6.67E-5
18 SGTC_3332 9141069 3.78 11.2 µM 7.25E-5 19 7.81E-5
19 SGTC_2860 9025725 3.77 39.0 µM 7.68E-5 RPP1 & pyrimidine depletion 14 8.27E-5
20 SGTC_1800 st050079 3.75 29.1 µM 8.36E-5 NEO1-PIK1 132 8.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 5.53E-18 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.136 2.75E-15 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.129 7.99E-14 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.127 1.84E-13 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.114 3.34E-11 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.113 6.20E-11 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.105 1.08E-9 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.102 3.89E-9 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.101 3.92E-9 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.101 4.66E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.097 2.03E-8 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.096 2.32E-8 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.096 2.86E-8 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.095 3.47E-8 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.093 6.00E-8 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data