YCL037C / SRO9

Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL037C / SRO9

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.44E-34 ID:SGTC_64|Compound:000l-0018|FD-Score:5.27|P-value:2.88E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:5.01|P-value:8.12E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:-4.89|P-value:1.27E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.20|P-value:5.95E-19 ID:SGTC_177|Compound:1327-0068|FD-Score:4.94|P-value:1.07E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.72|P-value:6.87E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.14|P-value:1.86E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.89|P-value:1.30E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.79|P-value:5.51E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.39|P-value:1.79E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:4.05|P-value:2.50E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.79|P-value:5.54E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.25|P-value:1.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.24|P-value:2.32E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.49|P-value:5.72E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.41|P-value:7.56E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.07|P-value:6.41E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.63|P-value:8.86E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.96|P-value:1.01E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:6.03|P-value:1.06E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:3.65|P-value:8.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.93|P-value:4.62E-12 ID:SGTC_709|Compound:3807-1509|FD-Score:3.83|P-value:5.00E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.14|P-value:1.86E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:5.25|P-value:3.17E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.80|P-value:1.84E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.11|P-value:2.01E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-5.08|P-value:6.17E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.59|P-value:3.89E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.66|P-value:8.33E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.31|P-value:1.06E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:5.95|P-value:1.55E-7 ID:SGTC_1940|Compound:st075990|FD-Score:4.39|P-value:8.12E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.27|P-value:1.21E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-5.04|P-value:7.26E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.80|P-value:5.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.87|P-value:4.43E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.40|P-value:7.68E-5 ID:SGTC_2366|Compound:9070441|FD-Score:5.22|P-value:3.58E-6 ID:SGTC_2376|Compound:9072922|FD-Score:4.00|P-value:2.87E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.80|P-value:5.41E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.81|P-value:5.33E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.34|P-value:9.36E-5 ID:SGTC_2585|Compound:alliin|FD-Score:4.03|P-value:2.61E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.98|P-value:3.14E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.61|P-value:9.33E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.04|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.20|P-value:3.02E-10 ID:SGTC_2709|Compound:st078560|FD-Score:-3.81|P-value:5.28E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.39|P-value:7.99E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.71|P-value:7.03E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.75|P-value:6.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.76|P-value:1.20E-11 ID:SGTC_2912|Compound:7964298|FD-Score:8.71|P-value:3.45E-14 ID:SGTC_3155|Compound:9099265|FD-Score:-4.24|P-value:1.32E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.63|P-value:9.09E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.63|P-value:9.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.70|P-value:7.21E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.88|P-value:4.19E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.80|P-value:5.49E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:14.20|P-value:1.44E-34 ID:SGTC_64|Compound:000l-0018|FD-Score:5.27|P-value:2.88E-6 ID:SGTC_104|Compound:0074-0074|FD-Score:5.01|P-value:8.12E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:-4.89|P-value:1.27E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.20|P-value:5.95E-19 ID:SGTC_177|Compound:1327-0068|FD-Score:4.94|P-value:1.07E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.72|P-value:6.87E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:-4.14|P-value:1.86E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.89|P-value:1.30E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.79|P-value:5.51E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.39|P-value:1.79E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:4.05|P-value:2.50E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.79|P-value:5.54E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-4.25|P-value:1.26E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.24|P-value:2.32E-10 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.49|P-value:5.72E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.41|P-value:7.56E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.07|P-value:6.41E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.63|P-value:8.86E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.96|P-value:1.01E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:6.03|P-value:1.06E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:3.65|P-value:8.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:7.93|P-value:4.62E-12 ID:SGTC_709|Compound:3807-1509|FD-Score:3.83|P-value:5.00E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:4.14|P-value:1.86E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:5.25|P-value:3.17E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:4.80|P-value:1.84E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.11|P-value:2.01E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:-5.08|P-value:6.17E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.59|P-value:3.89E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.66|P-value:8.33E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.31|P-value:1.06E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:5.95|P-value:1.55E-7 ID:SGTC_1940|Compound:st075990|FD-Score:4.39|P-value:8.12E-5 ID:SGTC_1944|Compound:st076371|FD-Score:4.27|P-value:1.21E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-5.04|P-value:7.26E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.80|P-value:5.33E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.87|P-value:4.43E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.40|P-value:7.68E-5 ID:SGTC_2366|Compound:9070441|FD-Score:5.22|P-value:3.58E-6 ID:SGTC_2376|Compound:9072922|FD-Score:4.00|P-value:2.87E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.80|P-value:5.41E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.81|P-value:5.33E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.34|P-value:9.36E-5 ID:SGTC_2585|Compound:alliin|FD-Score:4.03|P-value:2.61E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.98|P-value:3.14E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.61|P-value:9.33E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.04|P-value:2.52E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.20|P-value:3.02E-10 ID:SGTC_2709|Compound:st078560|FD-Score:-3.81|P-value:5.28E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.39|P-value:7.99E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.71|P-value:7.03E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.75|P-value:6.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.76|P-value:1.20E-11 ID:SGTC_2912|Compound:7964298|FD-Score:8.71|P-value:3.45E-14 ID:SGTC_3155|Compound:9099265|FD-Score:-4.24|P-value:1.32E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.63|P-value:9.09E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.63|P-value:9.09E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.70|P-value:7.21E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.88|P-value:4.19E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.80|P-value:5.49E-4

Top fitness defect scores for YCL037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 14.20 9.0 µM 1.44E-34 cell wall 33 5.34E-46
2 SGTC_138 0850-0259 10.20 40.9 µM 5.95E-19 cell wall 42 6.03E-25
3 SGTC_2912 7964298 8.71 10.9 µM 3.45E-14 cell wall 22 1.56E-18
4 SGTC_673 1082-0474 7.93 110.0 µM 4.62E-12 RSC complex & mRNA processing 16 1.13E-15
5 SGTC_2688 kanamycin b 7.20 96.7 µM 3.02E-10 calcium & mitochondrial duress 100 3.11E-13
6 SGTC_583 1488-1091 6.03 88.9 µM 1.06E-7 6 8.04E-10
7 SGTC_1509 1326-1131 5.95 80.0 µM 1.55E-7 3 1.35E-9
8 SGTC_364 0083-0097 5.39 67.7 µM 1.79E-6 10 3.57E-8
9 SGTC_64 000l-0018 5.27 272.1 µM 2.88E-6 ubiquinone biosynthesis & proteasome 100 6.71E-8
10 SGTC_784 4579-0127 5.25 173.0 µM 3.17E-6 8 7.63E-8
11 SGTC_2366 9070441 5.22 60.6 µM 3.58E-6 7 9.01E-8
12 SGTC_104 0074-0074 5.01 591.0 µM 8.12E-6 4 2.69E-7
13 SGTC_582 0987-0078 4.96 156.0 µM 1.01E-5 calcium & mitochondrial duress 34 3.57E-7
14 SGTC_177 1327-0068 4.94 8.4 µM 1.07E-5 27 3.89E-7
15 SGTC_210 3551-0445 4.89 56.8 µM 1.30E-5 37 5.02E-7
16 SGTC_800 3448-7362 4.80 155.0 µM 1.84E-5 translation 100 8.03E-7
17 SGTC_1309 pyrazolanthrone 4.59 13.4 µM 3.89E-5 15 2.18E-6
18 SGTC_457 grayanotoxin iii 4.49 135.0 µM 5.72E-5 43 3.64E-6
19 SGTC_467 ro 31-8220 4.41 72.8 µM 7.56E-5 calcium & mitochondrial duress 60 5.28E-6
20 SGTC_2239 6685329 4.40 187.6 µM 7.68E-5 17 5.38E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 2.34E-69 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.282 2.45E-62 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.270 6.03E-57 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.256 2.10E-51 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.250 5.19E-49 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.249 1.83E-48 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.240 2.26E-45 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.240 4.39E-45 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.239 9.14E-45 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.236 9.64E-44 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.235 2.06E-43 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.233 1.93E-42 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.233 2.04E-42 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.232 3.86E-42 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.231 1.03E-41 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids