YCL038C / ATG22

Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL038C / ATG22

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:7.04|P-value:8.73E-14 ID:SGTC_121|Compound:0557-0495|FD-Score:5.26|P-value:1.93E-8 ID:SGTC_333|Compound:3486-0131|FD-Score:3.86|P-value:2.77E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.76|P-value:3.25E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.06|P-value:6.61E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.07|P-value:6.36E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.12|P-value:8.28E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.15|P-value:4.94E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.99|P-value:8.56E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.75|P-value:4.45E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.06|P-value:1.09E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.07|P-value:1.05E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.44|P-value:1.64E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.97|P-value:9.58E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.14|P-value:5.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.51|P-value:1.21E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.63|P-value:7.20E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.29|P-value:2.88E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.66|P-value:6.55E-5 ID:SGTC_2014|Compound:4013930|FD-Score:5.06|P-value:5.99E-8 ID:SGTC_2018|Compound:5133068|FD-Score:-3.38|P-value:2.00E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.78|P-value:3.79E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-3.13|P-value:5.21E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-6.59|P-value:2.55E-12 ID:SGTC_2176|Compound:5809774|FD-Score:4.27|P-value:4.12E-6 ID:SGTC_2181|Compound:6316240|FD-Score:4.91|P-value:1.38E-7 ID:SGTC_2182|Compound:6325192|FD-Score:3.88|P-value:2.54E-5 ID:SGTC_2186|Compound:6124449|FD-Score:9.88|P-value:2.35E-25 ID:SGTC_2266|Compound:7929956|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.33|P-value:2.39E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.08|P-value:6.28E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.58|P-value:8.64E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-3.52|P-value:1.12E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.27|P-value:3.75E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.22|P-value:3.77E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.07|P-value:6.40E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.76|P-value:4.22E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.33|P-value:2.51E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.32|P-value:2.58E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.43|P-value:1.69E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.53|P-value:1.09E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.25|P-value:3.30E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.84|P-value:2.96E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:7.04|P-value:8.73E-14 ID:SGTC_121|Compound:0557-0495|FD-Score:5.26|P-value:1.93E-8 ID:SGTC_333|Compound:3486-0131|FD-Score:3.86|P-value:2.77E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:4.76|P-value:3.25E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.06|P-value:6.61E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.07|P-value:6.36E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.12|P-value:8.28E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.15|P-value:4.94E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.99|P-value:8.56E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.75|P-value:4.45E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.06|P-value:1.09E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.07|P-value:1.05E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.44|P-value:1.64E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:2.97|P-value:9.58E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.14|P-value:5.18E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.51|P-value:1.21E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-3.63|P-value:7.20E-5 ID:SGTC_1830|Compound:st055982|FD-Score:3.29|P-value:2.88E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.66|P-value:6.55E-5 ID:SGTC_2014|Compound:4013930|FD-Score:5.06|P-value:5.99E-8 ID:SGTC_2018|Compound:5133068|FD-Score:-3.38|P-value:2.00E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.78|P-value:3.79E-5 ID:SGTC_2069|Compound:5228469|FD-Score:-3.13|P-value:5.21E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-6.59|P-value:2.55E-12 ID:SGTC_2176|Compound:5809774|FD-Score:4.27|P-value:4.12E-6 ID:SGTC_2181|Compound:6316240|FD-Score:4.91|P-value:1.38E-7 ID:SGTC_2182|Compound:6325192|FD-Score:3.88|P-value:2.54E-5 ID:SGTC_2186|Compound:6124449|FD-Score:9.88|P-value:2.35E-25 ID:SGTC_2266|Compound:7929956|FD-Score:3.99|P-value:1.50E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.33|P-value:2.39E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.08|P-value:6.28E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.58|P-value:8.64E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-3.52|P-value:1.12E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.27|P-value:3.75E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.22|P-value:3.77E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.07|P-value:6.40E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.76|P-value:4.22E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.33|P-value:2.51E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.32|P-value:2.58E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.43|P-value:1.69E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.02|P-value:8.04E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.53|P-value:1.09E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.25|P-value:3.30E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.84|P-value:2.96E-5

Top fitness defect scores for YCL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2186 6124449 9.88 200.0 µM 2.35E-25 RSC complex & mRNA processing 1 2.48E-23
2 SGTC_64 000l-0018 7.04 272.1 µM 8.73E-14 ubiquinone biosynthesis & proteasome 58 9.41E-13
3 SGTC_121 0557-0495 5.26 61.3 µM 1.93E-8 calcium & mitochondrial duress 24 7.33E-8
4 SGTC_2014 4013930 5.06 200.0 µM 5.99E-8 8 2.07E-7
5 SGTC_2181 6316240 4.91 54.3 µM 1.38E-7 8 4.44E-7
6 SGTC_372 0155-0182 4.76 15.9 µM 3.25E-7 mitochondrial response to ROS 18 9.75E-7
7 SGTC_2176 5809774 4.27 34.0 µM 4.12E-6 mitochondrial processes 9 1.00E-5
8 SGTC_884 0851-0618 4.12 334.0 µM 8.28E-6 13 1.90E-5
9 SGTC_1172 0370-0043 4.07 85.0 µM 1.05E-5 20 2.36E-5
10 SGTC_1083 didemethylchlorpromazine sulfoxide 4.06 707.4 nM 1.09E-5 redox potentiating 76 2.45E-5
11 SGTC_2266 7929956 3.99 200.0 µM 1.50E-5 32 3.28E-5
12 SGTC_2182 6325192 3.88 200.0 µM 2.54E-5 Golgi 15 5.30E-5
13 SGTC_333 3486-0131 3.86 40.1 µM 2.77E-5 amide catabolism 13 5.75E-5
14 SGTC_3353 9151644 3.84 39.3 µM 2.96E-5 14 6.11E-5
15 SGTC_2557 derrustone 3.76 83.8 µM 4.22E-5 44 8.46E-5
16 SGTC_1047 2043-3044 3.75 82.0 µM 4.45E-5 43 8.88E-5
17 SGTC_1916 st067606 3.66 49.2 µM 6.55E-5 52 1.27E-4
18 SGTC_1754 st042065 3.51 16.1 µM 1.21E-4 NEO1-PIK1 218 2.23E-4
19 SGTC_1178 0988-0033 3.44 191.0 µM 1.64E-4 46 2.95E-4
20 SGTC_2860 9025725 3.43 39.0 µM 1.69E-4 RPP1 & pyrimidine depletion 22 3.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.27E-18 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.123 9.41E-13 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.121 1.79E-12 YNL255C GIS2 hom Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
0.121 2.02E-12 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.118 5.98E-12 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.118 6.70E-12 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.117 1.12E-11 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.117 1.18E-11 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.116 1.41E-11 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.116 1.88E-11 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.111 1.17E-10 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.107 5.46E-10 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.105 9.25E-10 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.105 1.28E-9 YLR127C APC2 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.104 1.49E-9 YJR134C SGM1 hom Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus