YCL039W / GID7

Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL039W / GID7

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:3.36E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.98|P-value:2.59E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.21|P-value:9.61E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.13|P-value:1.38E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.31|P-value:3.91E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.11|P-value:7.99E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.87|P-value:3.77E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.06|P-value:9.38E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.14|P-value:7.22E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.29|P-value:4.07E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.14|P-value:7.05E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.13|P-value:1.39E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.80|P-value:5.91E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-5.08|P-value:1.29E-7 ID:SGTC_2029|Compound:5175081|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.36|P-value:3.34E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.84|P-value:4.79E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.70|P-value:8.37E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.96|P-value:2.92E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.30|P-value:4.17E-4 ID:SGTC_2358|Compound:9037157|FD-Score:6.11|P-value:2.72E-10 ID:SGTC_2360|Compound:9040895|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.52|P-value:1.04E-8 ID:SGTC_2380|Compound:9035439|FD-Score:3.24|P-value:4.91E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.60|P-value:1.54E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_2464|Compound:5717415|FD-Score:6.16|P-value:1.98E-10 ID:SGTC_2466|Compound:5983409|FD-Score:4.69|P-value:9.62E-7 ID:SGTC_2467|Compound:5474540|FD-Score:5.23|P-value:5.46E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.32|P-value:5.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:4.63E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.10|P-value:8.42E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.21|P-value:5.51E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.31|P-value:3.77E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.08|P-value:9.08E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.45|P-value:2.28E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.79|P-value:5.98E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.28|P-value:4.30E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.10|P-value:1.12E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:2.20E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.92|P-value:3.36E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.98|P-value:2.59E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.21|P-value:9.61E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:4.13|P-value:1.38E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.58|P-value:1.41E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.31|P-value:3.91E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.11|P-value:7.99E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.87|P-value:3.77E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.06|P-value:9.38E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.14|P-value:7.22E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.29|P-value:4.07E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.14|P-value:7.05E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.07|P-value:8.95E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-4.13|P-value:1.39E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.80|P-value:5.91E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-5.08|P-value:1.29E-7 ID:SGTC_2029|Compound:5175081|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.36|P-value:3.34E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.53|P-value:1.70E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.84|P-value:4.79E-5 ID:SGTC_2179|Compound:6298986|FD-Score:3.70|P-value:8.37E-5 ID:SGTC_2231|Compound:micatex|FD-Score:3.96|P-value:2.92E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.30|P-value:4.17E-4 ID:SGTC_2358|Compound:9037157|FD-Score:6.11|P-value:2.72E-10 ID:SGTC_2360|Compound:9040895|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_2363|Compound:9053361|FD-Score:5.52|P-value:1.04E-8 ID:SGTC_2380|Compound:9035439|FD-Score:3.24|P-value:4.91E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-4.60|P-value:1.54E-6 ID:SGTC_2463|Compound:5473429|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_2464|Compound:5717415|FD-Score:6.16|P-value:1.98E-10 ID:SGTC_2466|Compound:5983409|FD-Score:4.69|P-value:9.62E-7 ID:SGTC_2467|Compound:5474540|FD-Score:5.23|P-value:5.46E-8 ID:SGTC_2482|Compound:5981709|FD-Score:4.32|P-value:5.68E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:4.63E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.10|P-value:8.42E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.21|P-value:5.51E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.31|P-value:3.77E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.13|P-value:7.44E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.08|P-value:9.08E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.45|P-value:2.28E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.79|P-value:5.98E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.28|P-value:4.30E-4 ID:SGTC_3329|Compound:9141233|FD-Score:5.10|P-value:1.12E-7 ID:SGTC_3334|Compound:9142812|FD-Score:3.46|P-value:2.20E-4

Top fitness defect scores for YCL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2464 5717415 6.16 7.7 µM 1.98E-10 1 3.69E-10
2 SGTC_2358 9037157 6.11 4.0 µM 2.72E-10 5 5.02E-10
3 SGTC_2363 9053361 5.52 176.0 µM 1.04E-8 Golgi 9 1.73E-8
4 SGTC_2467 5474540 5.23 200.0 µM 5.46E-8 4 8.60E-8
5 SGTC_3329 9141233 5.10 27.6 µM 1.12E-7 4 1.72E-7
6 SGTC_1193 1488-0126 4.87 41.5 µM 3.77E-7 11 5.61E-7
7 SGTC_2466 5983409 4.69 37.1 µM 9.62E-7 13 1.39E-6
8 SGTC_2482 5981709 4.32 142.7 µM 5.68E-6 PDR1 30 7.80E-6
9 SGTC_890 0929-0006 4.13 47.2 µM 1.38E-5 16 1.84E-5
10 SGTC_164 4100-3994 3.98 89.6 µM 2.59E-5 31 3.41E-5
11 SGTC_2463 5473429 3.96 200.0 µM 2.83E-5 ERG2 15 3.70E-5
12 SGTC_2231 micatex 3.96 6.8 µM 2.92E-5 16 3.82E-5
13 SGTC_87 0100-0052 3.92 35.5 µM 3.36E-5 106 4.39E-5
14 SGTC_2160 5660466 3.84 132.9 µM 4.79E-5 60S ribosome export 20 6.18E-5
15 SGTC_3298 9116858 3.79 71.4 µM 5.98E-5 13 7.67E-5
16 SGTC_2179 6298986 3.70 200.0 µM 8.37E-5 heme requiring 22 1.06E-4
17 SGTC_2029 5175081 3.61 200.0 µM 1.22E-4 30 1.53E-4
18 SGTC_178 4092-0806 3.58 87.5 µM 1.35E-4 ergosterol depletion effects on membrane 114 1.69E-4
19 SGTC_2147 5545932 3.53 89.7 µM 1.70E-4 ergosterol biosynthesis 23 2.11E-4
20 SGTC_3334 9142812 3.46 21.9 µM 2.20E-4 42 2.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.12E-10 YJL103C GSM1 hom Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
0.104 1.46E-9 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.095 4.06E-8 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.091 1.41E-7 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.086 6.23E-7 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.084 1.14E-6 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.084 1.20E-6 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.083 1.59E-6 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.083 1.62E-6 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.081 2.82E-6 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.081 3.05E-6 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.079 5.20E-6 YBL008W HIR1 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
0.077 7.36E-6 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.077 7.80E-6 YER167W BCK2 hom Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
0.076 1.14E-5 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress