YCL041C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCL041C / YCL041C

Click on Significant Values for Screen Details ID:SGTC_727|Compound:3032-0951|FD-Score:-2.99|P-value:9.26E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.01|P-value:7.60E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.44|P-value:1.68E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-2.99|P-value:9.33E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.95|P-value:1.94E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.45|P-value:1.61E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.23|P-value:3.93E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.15|P-value:4.46E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.01|P-value:1.21E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.08|P-value:6.76E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.05|P-value:6.39E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.49|P-value:1.20E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.99|P-value:7.95E-4 ID:SGTC_2414|Compound:st077232|FD-Score:6.20|P-value:3.48E-11 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.35|P-value:2.89E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.02|P-value:7.30E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-4.28|P-value:3.97E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.93|P-value:1.74E-5 ID:SGTC_2449|Compound:5812982|FD-Score:3.71|P-value:4.57E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.64|P-value:7.33E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.29|P-value:3.12E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:2.93|P-value:9.89E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.48|P-value:1.47E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.76|P-value:2.82E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.65|P-value:6.08E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:6.71|P-value:8.63E-13 ID:SGTC_2904|Compound:7225135|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.06|P-value:7.27E-4 ID:SGTC_3038|Compound:9091290|FD-Score:4.35|P-value:2.35E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.66|P-value:6.91E-5 ID:SGTC_3256|Compound:9138902|FD-Score:3.20|P-value:3.68E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.00|P-value:7.83E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.07|P-value:5.98E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-2.99|P-value:9.26E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.01|P-value:7.60E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.19|P-value:3.85E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.44|P-value:1.68E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-2.99|P-value:9.33E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.95|P-value:1.94E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.45|P-value:1.61E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.23|P-value:3.93E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.15|P-value:4.46E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.46|P-value:1.34E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.01|P-value:1.21E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.08|P-value:6.76E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.05|P-value:6.39E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.49|P-value:1.20E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.99|P-value:7.95E-4 ID:SGTC_2414|Compound:st077232|FD-Score:6.20|P-value:3.48E-11 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.35|P-value:2.89E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.02|P-value:7.30E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-4.28|P-value:3.97E-6 ID:SGTC_2429|Compound:5902844|FD-Score:3.93|P-value:1.74E-5 ID:SGTC_2449|Compound:5812982|FD-Score:3.71|P-value:4.57E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.64|P-value:7.33E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.29|P-value:3.12E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:2.93|P-value:9.89E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.48|P-value:1.47E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.87|P-value:2.27E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.76|P-value:2.82E-7 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.65|P-value:6.08E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:6.71|P-value:8.63E-13 ID:SGTC_2904|Compound:7225135|FD-Score:3.02|P-value:7.12E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.06|P-value:7.27E-4 ID:SGTC_3038|Compound:9091290|FD-Score:4.35|P-value:2.35E-6 ID:SGTC_3144|Compound:9087057|FD-Score:-3.66|P-value:6.91E-5 ID:SGTC_3256|Compound:9138902|FD-Score:3.20|P-value:3.68E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.00|P-value:7.83E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.07|P-value:5.98E-4

Top fitness defect scores for YCL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2758 dehydroepiandrosterone 6.71 69.3 µM 8.63E-13 1 9.48E-12 0.96
2 SGTC_2414 st077232 6.20 92.9 µM 3.48E-11 1 2.74E-10 1.07
3 SGTC_2749 bexarotene 4.76 57.4 µM 2.82E-7 1 9.90E-7 0.68
4 SGTC_3038 9091290 4.35 49.5 µM 2.35E-6 1 6.84E-6 0.58
5 SGTC_2558 carylophyllene oxide 4.29 100.0 µM 3.12E-6 2 8.85E-6 0.95
6 SGTC_1989 st071868 4.01 50.2 µM 1.21E-5 5 3.05E-5 0.09
7 SGTC_2429 5902844 3.93 64.4 µM 1.74E-5 9 4.23E-5 0.24
8 SGTC_2683 piperine 3.87 63.0 µM 2.27E-5 1 5.39E-5 0.40
9 SGTC_2449 5812982 3.71 45.8 µM 4.57E-5 7 1.02E-4 0.30
10 SGTC_2757 clomiphene 3.65 4.2 µM 6.08E-5 fatty acid desaturase (OLE1) 17 1.32E-4 0.02
11 SGTC_2399 5884133 3.49 200.0 µM 1.20E-4 cell wall signaling 22 2.46E-4 0.02
12 SGTC_2389 9091542 3.47 195.5 µM 1.30E-4 iron homeostasis 8 2.64E-4 0.06
13 SGTC_1753 st043925 3.46 64.0 µM 1.34E-4 5 2.72E-4 0.13
14 SGTC_2540 epiandrosterone 3.41 100.0 µM 1.62E-4 8 3.23E-4 0.02
15 SGTC_3256 9138902 3.20 49.5 µM 3.68E-4 PDR1 1 6.83E-4 0.25
16 SGTC_942 3253-1115 3.19 227.0 µM 3.85E-4 20 7.12E-4 0.08
17 SGTC_1735 st034310 3.15 56.8 µM 4.46E-4 Golgi 19 8.14E-4 0.19
18 SGTC_2408 sulbentine 3.15 18.4 µM 4.47E-4 55 8.15E-4 0.14
19 SGTC_3310 9130229 3.07 44.1 µM 5.98E-4 Golgi 12 0.00106 0.06
20 SGTC_2379 9035213 3.05 200.0 µM 6.39E-4 13 0.00113 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.70E-18 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.145 2.97E-17 YAL005C SSA1 hom ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
0.123 7.70E-13 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.122 1.14E-12 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.117 1.25E-11 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.113 4.79E-11 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.112 7.09E-11 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.106 6.70E-10 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.104 1.33E-9 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.104 1.34E-9 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.104 1.82E-9 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.103 2.29E-9 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.100 6.04E-9 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.094 4.73E-8 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.093 6.16E-8 YOR356W CIR2 hom Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response