YCL042W_p

Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL042W / YCL042W

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.16|P-value:1.12E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:4.14|P-value:7.71E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.80|P-value:2.45E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.61|P-value:4.58E-4 ID:SGTC_469|Compound:w7|FD-Score:4.58|P-value:1.45E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.40|P-value:9.15E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.95|P-value:3.01E-6 ID:SGTC_489|Compound:paxilline|FD-Score:4.52|P-value:1.80E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.96|P-value:1.42E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.50|P-value:6.99E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.20|P-value:6.18E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.83|P-value:2.20E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.69|P-value:3.56E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.21|P-value:5.96E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.10|P-value:8.97E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.54|P-value:5.80E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.38|P-value:3.16E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.15|P-value:7.49E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:7.81|P-value:4.69E-13 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.57|P-value:5.27E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.55|P-value:6.01E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.70|P-value:3.69E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.10|P-value:8.88E-5 ID:SGTC_1673|Compound:st016611|FD-Score:4.59|P-value:1.40E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.71|P-value:8.51E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.80|P-value:2.55E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.55|P-value:5.89E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.48|P-value:7.37E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.40|P-value:4.04E-7 ID:SGTC_2400|Compound:5203494|FD-Score:4.85|P-value:4.73E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-3.68|P-value:3.64E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.99|P-value:1.35E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.72|P-value:3.44E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.70|P-value:8.64E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.72|P-value:3.43E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.49|P-value:2.02E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.16|P-value:1.12E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.45|P-value:8.16E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:4.14|P-value:7.71E-5 ID:SGTC_462|Compound:ag-879|FD-Score:-3.80|P-value:2.45E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.61|P-value:4.58E-4 ID:SGTC_469|Compound:w7|FD-Score:4.58|P-value:1.45E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.40|P-value:9.15E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.95|P-value:3.01E-6 ID:SGTC_489|Compound:paxilline|FD-Score:4.52|P-value:1.80E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.96|P-value:1.42E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.50|P-value:6.99E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.20|P-value:6.18E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.83|P-value:2.20E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.69|P-value:3.56E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.21|P-value:5.96E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.66|P-value:4.16E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.10|P-value:8.97E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.57|P-value:5.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.54|P-value:5.80E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.38|P-value:3.16E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.15|P-value:7.49E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:7.81|P-value:4.69E-13 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.57|P-value:5.27E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.55|P-value:6.01E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.70|P-value:3.69E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.10|P-value:8.88E-5 ID:SGTC_1673|Compound:st016611|FD-Score:4.59|P-value:1.40E-5 ID:SGTC_1952|Compound:st077036|FD-Score:4.71|P-value:8.51E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.80|P-value:2.55E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.55|P-value:5.89E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.48|P-value:7.37E-4 ID:SGTC_2397|Compound:5161689|FD-Score:5.40|P-value:4.04E-7 ID:SGTC_2400|Compound:5203494|FD-Score:4.85|P-value:4.73E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-3.68|P-value:3.64E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.99|P-value:1.35E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.72|P-value:3.44E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.70|P-value:8.64E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.72|P-value:3.43E-4

Top fitness defect scores for YCL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1377 2944-0135 7.81 198.0 µM 4.69E-13 calcium & mitochondrial duress 7 2.91E-15
2 SGTC_2397 5161689 5.40 200.0 µM 4.04E-7 10 3.37E-8
3 SGTC_486 niguldipine 4.95 82.0 µM 3.01E-6 amide catabolism 9 3.67E-7
4 SGTC_2400 5203494 4.85 178.7 µM 4.73E-6 RSC complex & mRNA processing 14 6.28E-7
5 SGTC_1952 st077036 4.71 64.1 µM 8.51E-6 16 1.26E-6
6 SGTC_3207 9114163 4.70 49.5 µM 8.64E-6 13 1.28E-6
7 SGTC_1673 st016611 4.59 27.3 µM 1.40E-5 29 2.27E-6
8 SGTC_469 w7 4.58 172.0 µM 1.45E-5 ERG2 8 2.37E-6
9 SGTC_489 paxilline 4.52 115.0 µM 1.80E-5 PDR1 7 3.07E-6
10 SGTC_137 0438-0332 4.49 85.4 µM 2.02E-5 ubiquinone biosynthesis & proteasome 94 3.51E-6
11 SGTC_1267 0828-0272 4.38 9.5 µM 3.16E-5 13 5.97E-6
12 SGTC_787 4152-0075 4.21 138.0 µM 5.96E-5 20 1.27E-5
13 SGTC_638 3970-0837 4.20 4.1 µM 6.18E-5 30 1.32E-5
14 SGTC_1371 2421-0008 4.15 32.7 µM 7.49E-5 mitochondrial processes 28 1.66E-5
15 SGTC_460 trequinsin 4.14 123.0 µM 7.71E-5 1 1.72E-5
16 SGTC_1625 st003711 4.10 30.1 µM 8.88E-5 calcium & mitochondrial duress 31 2.03E-5
17 SGTC_1011 4112-3381 4.10 17.4 µM 8.97E-5 37 2.06E-5
18 SGTC_2517 totarol 3.99 10.0 µM 1.35E-4 18 3.35E-5
19 SGTC_2016 5121758 3.80 140.0 µM 2.55E-4 redox potentiating 60 7.10E-5
20 SGTC_3210 9128157 3.72 49.5 µM 3.43E-4 55 1.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.15E-13 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.094 5.68E-8 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.093 5.86E-8 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.091 1.13E-7 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.082 1.93E-6 YBR254C TRS20 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
0.079 4.08E-6 YPR018W RLF2 hom Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.079 4.12E-6 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.077 7.36E-6 YIL092W_p YIL092W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.075 1.32E-5 YOR253W NAT5 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.075 1.45E-5 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.074 1.78E-5 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.073 2.41E-5 YER042W MXR1 hom Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
0.072 3.17E-5 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.071 3.65E-5 YBR180W DTR1 hom Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
0.067 9.32E-5 YGL001C ERG26 het C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis