YCL046W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL046W / YCL046W

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:8.63|P-value:7.49E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:4.59|P-value:3.40E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:5.09|P-value:2.88E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:5.92|P-value:2.81E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:3.31|P-value:6.18E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.84|P-value:8.57E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.21|P-value:8.75E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.45|P-value:6.27E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.28|P-value:6.98E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.36|P-value:9.62E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.93|P-value:3.44E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.33|P-value:5.78E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.69|P-value:9.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.42|P-value:4.23E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.59|P-value:1.37E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.40|P-value:4.45E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.28|P-value:6.81E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.56|P-value:3.85E-6 ID:SGTC_1675|Compound:st018485|FD-Score:5.10|P-value:2.70E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.07|P-value:8.92E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.01|P-value:4.32E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.29|P-value:7.11E-6 ID:SGTC_1750|Compound:st081859|FD-Score:19.50|P-value:7.77E-84 ID:SGTC_1770|Compound:st043884|FD-Score:4.23|P-value:1.67E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.80|P-value:1.19E-6 ID:SGTC_1835|Compound:st008666|FD-Score:3.34|P-value:5.49E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.37|P-value:4.97E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.53|P-value:4.39E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.12|P-value:2.66E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.10|P-value:8.20E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.52|P-value:4.66E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.08|P-value:8.65E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.08|P-value:8.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.44|P-value:6.75E-6 ID:SGTC_2476|Compound:5806916|FD-Score:3.91|P-value:6.44E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.24|P-value:1.65E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.11|P-value:2.84E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.56|P-value:2.52E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.48|P-value:3.42E-4 ID:SGTC_2696|Compound:st077691|FD-Score:7.83|P-value:5.25E-15 ID:SGTC_2787|Compound:5284540|FD-Score:-3.72|P-value:8.21E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.55|P-value:2.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.49|P-value:2.01E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.14|P-value:2.13E-7 ID:SGTC_3173|Compound:9105693|FD-Score:4.27|P-value:1.45E-5 ID:SGTC_3174|Compound:9107204|FD-Score:4.03|P-value:4.02E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.61|P-value:1.59E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-4.87|P-value:4.34E-7 ID:SGTC_3232|Compound:9132874|FD-Score:3.20|P-value:8.96E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:8.63|P-value:7.49E-18 ID:SGTC_163|Compound:1327-0036|FD-Score:4.59|P-value:3.40E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:5.09|P-value:2.88E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:5.92|P-value:2.81E-9 ID:SGTC_280|Compound:3448-3607|FD-Score:3.31|P-value:6.18E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.84|P-value:8.57E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.21|P-value:8.75E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.45|P-value:6.27E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.28|P-value:6.98E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.36|P-value:9.62E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:-3.93|P-value:3.44E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.33|P-value:5.78E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.69|P-value:9.34E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.42|P-value:4.23E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.59|P-value:1.37E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.40|P-value:4.45E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.28|P-value:6.81E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.56|P-value:3.85E-6 ID:SGTC_1675|Compound:st018485|FD-Score:5.10|P-value:2.70E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-3.07|P-value:8.92E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.01|P-value:4.32E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.29|P-value:7.11E-6 ID:SGTC_1750|Compound:st081859|FD-Score:19.50|P-value:7.77E-84 ID:SGTC_1770|Compound:st043884|FD-Score:4.23|P-value:1.67E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1810|Compound:st050138|FD-Score:-3.19|P-value:5.87E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.80|P-value:1.19E-6 ID:SGTC_1835|Compound:st008666|FD-Score:3.34|P-value:5.49E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.37|P-value:4.97E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.53|P-value:4.39E-6 ID:SGTC_2149|Compound:5554786|FD-Score:4.12|P-value:2.66E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.10|P-value:8.20E-4 ID:SGTC_2241|Compound:6772625|FD-Score:4.52|P-value:4.66E-6 ID:SGTC_2255|Compound:7941087|FD-Score:-3.08|P-value:8.65E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.08|P-value:8.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.44|P-value:6.75E-6 ID:SGTC_2476|Compound:5806916|FD-Score:3.91|P-value:6.44E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.24|P-value:1.65E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.11|P-value:2.84E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.56|P-value:2.52E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.48|P-value:3.42E-4 ID:SGTC_2696|Compound:st077691|FD-Score:7.83|P-value:5.25E-15 ID:SGTC_2787|Compound:5284540|FD-Score:-3.72|P-value:8.21E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.55|P-value:2.58E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.29|P-value:4.19E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.49|P-value:2.01E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.14|P-value:2.13E-7 ID:SGTC_3173|Compound:9105693|FD-Score:4.27|P-value:1.45E-5 ID:SGTC_3174|Compound:9107204|FD-Score:4.03|P-value:4.02E-5 ID:SGTC_3207|Compound:9114163|FD-Score:-4.61|P-value:1.59E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-4.87|P-value:4.34E-7 ID:SGTC_3232|Compound:9132874|FD-Score:3.20|P-value:8.96E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.77|P-value:1.12E-4

Top fitness defect scores for YCL046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 19.50 2.4 µM 7.77E-84 endomembrane recycling 17 4.38E-85
2 SGTC_67 0335-0847 8.63 266.0 µM 7.49E-18 ubiquinone biosynthesis & proteasome 34 3.08E-18
3 SGTC_2696 st077691 7.83 74.3 µM 5.25E-15 2 2.40E-15
4 SGTC_279 1273-0055 5.92 2.9 µM 2.81E-9 azole & statin 15 1.62E-9
5 SGTC_3076 9116187 5.14 49.5 µM 2.13E-7 5 1.34E-7
6 SGTC_1675 st018485 5.10 24.5 µM 2.70E-7 60S ribosome export 11 1.70E-7
7 SGTC_176 1486-1328 5.09 72.8 µM 2.88E-7 30 1.82E-7
8 SGTC_1830 st055982 4.80 50.3 µM 1.19E-6 5 7.77E-7
9 SGTC_163 1327-0036 4.59 7.5 µM 3.40E-6 80 2.26E-6
10 SGTC_1550 gossypolone 4.56 36.6 µM 3.85E-6 5 2.57E-6
11 SGTC_2084 5306078 4.53 60.6 µM 4.39E-6 8 2.94E-6
12 SGTC_2241 6772625 4.52 37.8 µM 4.66E-6 16 3.13E-6
13 SGTC_562 3772-2733 4.45 112.0 µM 6.27E-6 ERG2 65 4.23E-6
14 SGTC_2450 5739737 4.44 12.9 µM 6.75E-6 13 4.57E-6
15 SGTC_684 1140-0066 4.36 328.0 µM 9.62E-6 Golgi 14 6.56E-6
16 SGTC_3173 9105693 4.27 49.5 µM 1.45E-5 14 9.98E-6
17 SGTC_2588 indole-3-carbinol 4.24 100.0 µM 1.65E-5 38 1.14E-5
18 SGTC_1770 st043884 4.23 66.3 µM 1.67E-5 11 1.15E-5
19 SGTC_2149 5554786 4.12 194.8 µM 2.66E-5 cell wall signaling 32 1.86E-5
20 SGTC_2594 a-mangostin 4.11 100.0 µM 2.84E-5 28 1.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.429 4.66E-150 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.356 7.96E-101 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.346 7.47E-95 YPR153W YPR153W hom Putative protein of unknown function
0.314 2.09E-77 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.288 7.44E-65 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.276 1.15E-59 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.261 3.07E-53 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.246 2.77E-47 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.225 1.16E-39 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.220 7.46E-38 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.215 3.10E-36 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213 1.16E-35 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.207 1.23E-33 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.205 4.67E-33 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.205 5.35E-33 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C