YCL055W / KAR4

Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL055W / KAR4

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.45|P-value:2.86E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.34|P-value:4.96E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.20|P-value:7.99E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.12|P-value:6.82E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.04|P-value:9.08E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.82|P-value:4.76E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.10|P-value:7.49E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.08|P-value:8.01E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.87|P-value:3.88E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.43|P-value:3.22E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-4.98|P-value:3.85E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.42|P-value:3.75E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.37|P-value:4.28E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.27|P-value:6.40E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.40|P-value:2.48E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.24|P-value:4.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.57|P-value:2.12E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.85|P-value:4.19E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.36|P-value:2.89E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.18|P-value:9.85E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.69|P-value:7.98E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.98|P-value:1.99E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.18|P-value:1.02E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.86|P-value:3.95E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.33|P-value:3.23E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.93|P-value:2.65E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.38|P-value:4.48E-8 ID:SGTC_2645|Compound:abamectin|FD-Score:3.90|P-value:3.38E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.84|P-value:4.47E-5 ID:SGTC_2831|Compound:7999036|FD-Score:7.43|P-value:2.54E-14 ID:SGTC_2936|Compound:9038235|FD-Score:3.80|P-value:5.19E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.44|P-value:3.01E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.08|P-value:7.84E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.48|P-value:2.43E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.25|P-value:6.80E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.45|P-value:2.86E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.34|P-value:4.96E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.20|P-value:7.99E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.12|P-value:6.82E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.51|P-value:1.62E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.04|P-value:9.08E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.69|P-value:1.33E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.82|P-value:4.76E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.10|P-value:7.49E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.08|P-value:8.01E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.87|P-value:3.88E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.43|P-value:3.22E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-4.98|P-value:3.85E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.42|P-value:3.75E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.37|P-value:4.28E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.27|P-value:6.40E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.40|P-value:2.48E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.24|P-value:4.44E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-3.57|P-value:2.12E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.48|P-value:1.84E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.85|P-value:4.19E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.36|P-value:2.89E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.59|P-value:1.20E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.18|P-value:9.85E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.69|P-value:7.98E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.98|P-value:1.99E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.18|P-value:1.02E-5 ID:SGTC_2378|Compound:9074213|FD-Score:3.25|P-value:4.35E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.86|P-value:3.95E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.33|P-value:3.23E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.93|P-value:2.65E-7 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.38|P-value:4.48E-8 ID:SGTC_2645|Compound:abamectin|FD-Score:3.90|P-value:3.38E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.84|P-value:4.47E-5 ID:SGTC_2831|Compound:7999036|FD-Score:7.43|P-value:2.54E-14 ID:SGTC_2936|Compound:9038235|FD-Score:3.80|P-value:5.19E-5 ID:SGTC_3054|Compound:9094397|FD-Score:4.44|P-value:3.01E-6 ID:SGTC_3149|Compound:9097855|FD-Score:3.08|P-value:7.84E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.48|P-value:2.43E-6 ID:SGTC_3238|Compound:9133470|FD-Score:3.70|P-value:7.68E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.25|P-value:6.80E-4

Top fitness defect scores for YCL055W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2831 7999036 7.43 19.5 µM 2.54E-14 2 5.48E-14
2 SGTC_2347 9049783 4.98 174.8 µM 1.99E-7 11 3.15E-7
3 SGTC_2562 3',7'-dimethoxyflavone 4.93 64.9 µM 2.65E-7 10 4.17E-7
4 SGTC_3187 9109394 4.48 49.5 µM 2.43E-6 Golgi 10 3.65E-6
5 SGTC_36 0335-0881 4.45 14.2 µM 2.86E-6 ubiquinone biosynthesis & proteasome 100 4.27E-6
6 SGTC_3054 9094397 4.44 49.5 µM 3.01E-6 fatty acid desaturase (OLE1) 18 4.50E-6
7 SGTC_1245 0418-0076 4.43 17.2 µM 3.22E-6 ERG2 22 4.80E-6
8 SGTC_1454 4239-0054 4.37 42.6 µM 4.28E-6 21 6.34E-6
9 SGTC_2318 6029776 4.18 164.0 µM 9.85E-6 22 1.43E-5
10 SGTC_2348 9022543 4.18 33.4 µM 1.02E-5 mitochondrial processes 22 1.49E-5
11 SGTC_2645 abamectin 3.90 100.0 µM 3.38E-5 heme requiring 32 4.78E-5
12 SGTC_1132 3456-3614 3.87 2.5 µM 3.88E-5 tubulin folding & SWR complex 52 5.46E-5
13 SGTC_2384 9036245 3.86 200.0 µM 3.95E-5 31 5.56E-5
14 SGTC_2087 5276107 3.85 200.0 µM 4.19E-5 19 5.89E-5
15 SGTC_2808 7946468 3.84 45.5 µM 4.47E-5 27 6.27E-5
16 SGTC_609 0986-0026 3.82 86.3 µM 4.76E-5 calcium & mitochondrial duress 35 6.67E-5
17 SGTC_2936 9038235 3.80 15.6 µM 5.19E-5 23 7.25E-5
18 SGTC_3238 9133470 3.70 49.5 µM 7.68E-5 19 1.06E-4
19 SGTC_2331 7980721 3.69 200.0 µM 7.98E-5 33 1.10E-4
20 SGTC_728 3030-5151 3.63 22.5 µM 1.04E-4 24 1.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.68E-27 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.141 2.45E-16 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.106 7.13E-10 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.106 8.21E-10 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.099 7.80E-9 YCL029C BIK1 hom Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
0.098 1.27E-8 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.095 4.07E-8 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.094 4.69E-8 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.092 1.01E-7 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.090 1.54E-7 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.088 2.93E-7 YOL108C INO4 hom Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
0.086 5.77E-7 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.083 1.56E-6 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.083 1.72E-6 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.082 1.96E-6 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance