YCL056C / PEX34

Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL056C / PEX34

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.97|P-value:6.04E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.40|P-value:4.33E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.02|P-value:4.16E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.03|P-value:4.06E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.54|P-value:2.60E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.67|P-value:1.60E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.15|P-value:9.95E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.28|P-value:1.42E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.81|P-value:7.15E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.83|P-value:1.18E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.25|P-value:7.92E-13 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.46|P-value:4.88E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.23|P-value:9.74E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.45|P-value:4.71E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.47|P-value:6.17E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.24|P-value:7.55E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.41|P-value:8.11E-6 ID:SGTC_1930|Compound:st074634|FD-Score:4.86|P-value:1.03E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.83|P-value:1.20E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.17|P-value:9.24E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.87|P-value:7.70E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.82|P-value:1.24E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-5.01|P-value:7.04E-7 ID:SGTC_2275|Compound:7947463|FD-Score:-3.52|P-value:3.73E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:9.15E-4 ID:SGTC_2284|Compound:7945075|FD-Score:6.21|P-value:7.02E-10 ID:SGTC_2288|Compound:7946289|FD-Score:-4.10|P-value:4.12E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.28|P-value:1.43E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.21|P-value:8.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.25|P-value:9.17E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.51|P-value:3.80E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.70|P-value:1.94E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.46|P-value:6.47E-6 ID:SGTC_2780|Compound:5215298|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.77|P-value:2.21E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.98|P-value:6.73E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_2977|Compound:9011197|FD-Score:6.17|P-value:8.83E-10 ID:SGTC_2980|Compound:9014342|FD-Score:3.47|P-value:3.42E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.29|P-value:8.14E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.18|P-value:3.02E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.00|P-value:4.52E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-4.43|P-value:1.03E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-6.35|P-value:4.63E-10 ID:SGTC_3217|Compound:9129673|FD-Score:6.67|P-value:3.91E-11 ID:SGTC_3222|Compound:9128301|FD-Score:4.35|P-value:1.05E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.97|P-value:6.04E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:3.79|P-value:1.03E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.40|P-value:4.33E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.02|P-value:4.16E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:4.03|P-value:4.06E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.54|P-value:2.60E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.61|P-value:2.04E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.67|P-value:1.60E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.15|P-value:9.95E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.28|P-value:1.42E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:5.81|P-value:7.15E-9 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.83|P-value:1.18E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:7.25|P-value:7.92E-13 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.46|P-value:4.88E-8 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.23|P-value:9.74E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:-3.45|P-value:4.71E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.47|P-value:6.17E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.24|P-value:7.55E-4 ID:SGTC_1802|Compound:st050112|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.77|P-value:1.12E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.41|P-value:8.11E-6 ID:SGTC_1930|Compound:st074634|FD-Score:4.86|P-value:1.03E-6 ID:SGTC_1935|Compound:st074532|FD-Score:4.83|P-value:1.20E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.17|P-value:9.24E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.87|P-value:7.70E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.82|P-value:1.24E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-5.01|P-value:7.04E-7 ID:SGTC_2275|Compound:7947463|FD-Score:-3.52|P-value:3.73E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.25|P-value:9.15E-4 ID:SGTC_2284|Compound:7945075|FD-Score:6.21|P-value:7.02E-10 ID:SGTC_2288|Compound:7946289|FD-Score:-4.10|P-value:4.12E-5 ID:SGTC_2302|Compound:7771753|FD-Score:4.28|P-value:1.43E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.21|P-value:8.31E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.25|P-value:9.17E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.51|P-value:3.80E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.70|P-value:1.94E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.46|P-value:6.47E-6 ID:SGTC_2780|Compound:5215298|FD-Score:3.34|P-value:5.27E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.31|P-value:5.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-4.77|P-value:2.21E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.98|P-value:6.73E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_2977|Compound:9011197|FD-Score:6.17|P-value:8.83E-10 ID:SGTC_2980|Compound:9014342|FD-Score:3.47|P-value:3.42E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.29|P-value:8.14E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-4.18|P-value:3.02E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.00|P-value:4.52E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-4.43|P-value:1.03E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-6.35|P-value:4.63E-10 ID:SGTC_3217|Compound:9129673|FD-Score:6.67|P-value:3.91E-11 ID:SGTC_3222|Compound:9128301|FD-Score:4.35|P-value:1.05E-5

Top fitness defect scores for YCL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1249 0481-0015 7.25 10.2 µM 7.92E-13 5 2.06E-13
2 SGTC_3217 9129673 6.67 49.5 µM 3.91E-11 3 1.27E-11
3 SGTC_2284 7945075 6.21 39.2 µM 7.02E-10 mitochondrial processes 2 2.68E-10
4 SGTC_2977 9011197 6.17 71.4 µM 8.83E-10 5 3.42E-10
5 SGTC_1243 0416-0003 5.81 5.7 µM 7.15E-9 PDR1 8 3.11E-9
6 SGTC_1252 0493-0875 5.46 34.8 µM 4.88E-8 9 2.36E-8
7 SGTC_6 0844-0013 4.97 19.8 µM 6.04E-7 37 3.35E-7
8 SGTC_1930 st074634 4.86 34.3 µM 1.03E-6 RNA pol III & RNase P/MRP 19 5.90E-7
9 SGTC_1244 0416-0015 4.83 52.5 µM 1.18E-6 ERG2 14 6.77E-7
10 SGTC_1935 st074532 4.83 41.6 µM 1.20E-6 13 6.93E-7
11 SGTC_1629 st005085 4.47 44.9 µM 6.17E-6 RPP1 & pyrimidine depletion 21 3.88E-6
12 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.46 100.0 µM 6.47E-6 60S ribosome export 13 4.08E-6
13 SGTC_1846 st056244 4.41 14.8 µM 8.11E-6 15 5.18E-6
14 SGTC_2835 9006588 4.36 71.4 µM 1.01E-5 29 6.53E-6
15 SGTC_3222 9128301 4.35 49.5 µM 1.05E-5 60S ribosome export 17 6.78E-6
16 SGTC_1206 3978-0017 4.28 132.0 µM 1.42E-5 ERG2 26 9.31E-6
17 SGTC_2302 7771753 4.28 200.0 µM 1.43E-5 36 9.41E-6
18 SGTC_913 3487-1245 4.03 167.0 µM 4.06E-5 26 2.82E-5
19 SGTC_806 3966-4455 4.02 5.9 µM 4.16E-5 19 2.89E-5
20 SGTC_3178 9107506 4.00 49.5 µM 4.52E-5 13 3.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 8.50E-16 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.104 1.53E-9 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.093 7.35E-8 YBR253W SRB6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.092 8.35E-8 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.092 8.89E-8 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.088 3.01E-7 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 8.11E-7 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.078 5.62E-6 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.078 6.61E-6 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.077 7.95E-6 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.075 1.31E-5 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.074 1.57E-5 YLR258W GSY2 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.072 2.63E-5 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.072 2.64E-5 YKR043C SHB17 hom Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
0.072 3.24E-5 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)