HIPHOP chemogenomics database

YCL057C-A / MOS1

Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL057C-A / MOS1

Click on Significant Values for Screen Details

Top fitness defect scores for YCL057C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	15.30	5.3 µM	6.44E-53		97	4.43E-53
2	SGTC_2989	9073649	8.39	71.4 µM	2.00E-17		3	2.33E-17
3	SGTC_54	0159-0055	7.22	9.0 µM	2.19E-13	ERG2	16	2.63E-13
4	SGTC_1939	st074455	7.09	53.6 µM	5.70E-13		4	6.89E-13
5	SGTC_1383	3049-0032	5.54	20.7 µM	1.25E-8	60S ribosome export	3	1.53E-8
6	SGTC_436	n,n-dimethylsphingosine	5.39	3.3 µM	2.84E-8		8	3.48E-8
7	SGTC_1635	st007035	5.27	42.4 µM	5.51E-8		156	6.76E-8
8	SGTC_865	0488-0499	5.11	301.0 µM	1.33E-7		7	1.63E-7
9	SGTC_1966	st070145	4.90	16.1 µM	3.91E-7		10	4.78E-7
10	SGTC_2088	5278280	4.81	127.4 µM	6.13E-7		10	7.50E-7
11	SGTC_1193	1488-0126	4.66	41.5 µM	1.27E-6		16	1.56E-6
12	SGTC_2802	7925815	4.56	54.5 µM	2.11E-6		25	2.58E-6
13	SGTC_2615	purpurogallin-4-carboxylic acid	4.52	100.0 µM	2.55E-6	redox potentiating	47	3.11E-6
14	SGTC_3196	9111891	4.40	49.5 µM	4.46E-6	mitochondrial processes	13	5.43E-6
15	SGTC_1188	1403-0014	4.37	4.6 µM	5.05E-6	mitochondrial stress	39	6.15E-6
16	SGTC_908	3448-7491	4.35	47.7 µM	5.50E-6	mitochondrial stress	100	6.70E-6
17	SGTC_2546	rhodinyl acetate	4.01	100.0 µM	2.54E-5		12	3.08E-5
18	SGTC_386	1509-0011	3.88	3.1 µM	4.32E-5		148	5.22E-5
19	SGTC_1370	2001-0092	3.78	44.6 µM	6.56E-5		46	7.91E-5
20	SGTC_2912	7964298	3.60	10.9 µM	1.33E-4	cell wall	103	1.60E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.436	1.51E-155	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.424	4.20E-146	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.419	2.56E-142	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.408	7.81E-135	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.404	6.88E-132	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.400	2.32E-129	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.399	1.69E-128	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.389	1.22E-121	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.386	1.59E-119	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.383	6.49E-118	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.378	3.07E-114	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.377	8.70E-114	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.374	8.59E-112	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.374	9.96E-112	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.371	3.89E-110	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs