YCL057C-A / MOS1

Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL057C-A / MOS1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:7.22|P-value:2.19E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:15.30|P-value:6.44E-53 ID:SGTC_386|Compound:1509-0011|FD-Score:3.88|P-value:4.32E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.47|P-value:2.15E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.39|P-value:2.84E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:3.15|P-value:6.86E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:5.11|P-value:1.33E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:4.35|P-value:5.50E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.46|P-value:3.80E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.89|P-value:7.47E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.37|P-value:5.05E-6 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.66|P-value:1.27E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.05|P-value:9.78E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.08|P-value:8.81E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.78|P-value:6.56E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.54|P-value:1.25E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.26|P-value:7.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.27|P-value:5.51E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.42|P-value:4.30E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.23|P-value:5.11E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.29|P-value:6.84E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.20|P-value:9.33E-4 ID:SGTC_1939|Compound:st074455|FD-Score:7.09|P-value:5.70E-13 ID:SGTC_1943|Compound:st076331|FD-Score:-3.94|P-value:5.98E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.90|P-value:3.91E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.32|P-value:6.17E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.81|P-value:6.13E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.08|P-value:8.84E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.01|P-value:2.54E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-5.18|P-value:1.91E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.52|P-value:2.55E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.30|P-value:4.01E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.38|P-value:3.07E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.56|P-value:2.11E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.49|P-value:3.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.93|P-value:6.29E-5 ID:SGTC_2989|Compound:9073649|FD-Score:8.39|P-value:2.00E-17 ID:SGTC_3045|Compound:9092950|FD-Score:-3.21|P-value:8.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.85|P-value:8.48E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.05|P-value:9.52E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.40|P-value:4.46E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-3.89|P-value:7.22E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:7.22|P-value:2.19E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:15.30|P-value:6.44E-53 ID:SGTC_386|Compound:1509-0011|FD-Score:3.88|P-value:4.32E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.47|P-value:2.15E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.39|P-value:2.84E-8 ID:SGTC_588|Compound:3970-1144|FD-Score:3.15|P-value:6.86E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.51|P-value:1.84E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:5.11|P-value:1.33E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:4.35|P-value:5.50E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.46|P-value:3.80E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.89|P-value:7.47E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.37|P-value:5.05E-6 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.66|P-value:1.27E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.05|P-value:9.78E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.08|P-value:8.81E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.78|P-value:6.56E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.54|P-value:1.25E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.26|P-value:7.65E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.27|P-value:5.51E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.42|P-value:4.30E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.23|P-value:5.11E-4 ID:SGTC_1836|Compound:st055642|FD-Score:-3.29|P-value:6.84E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.20|P-value:9.33E-4 ID:SGTC_1939|Compound:st074455|FD-Score:7.09|P-value:5.70E-13 ID:SGTC_1943|Compound:st076331|FD-Score:-3.94|P-value:5.98E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.90|P-value:3.91E-7 ID:SGTC_1968|Compound:st069590|FD-Score:3.26|P-value:4.61E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.32|P-value:6.17E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_2088|Compound:5278280|FD-Score:4.81|P-value:6.13E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.38|P-value:3.06E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.08|P-value:8.84E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.01|P-value:2.54E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-5.18|P-value:1.91E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.52|P-value:2.55E-6 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.30|P-value:4.01E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.38|P-value:3.07E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.56|P-value:2.11E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.60|P-value:1.34E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.49|P-value:3.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.41|P-value:2.74E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.93|P-value:6.29E-5 ID:SGTC_2989|Compound:9073649|FD-Score:8.39|P-value:2.00E-17 ID:SGTC_3045|Compound:9092950|FD-Score:-3.21|P-value:8.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.85|P-value:8.48E-5 ID:SGTC_3167|Compound:9103034|FD-Score:3.05|P-value:9.52E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.40|P-value:4.46E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-3.89|P-value:7.22E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.51|P-value:1.84E-4

Top fitness defect scores for YCL057C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.30 5.3 µM 6.44E-53 97 4.43E-53
2 SGTC_2989 9073649 8.39 71.4 µM 2.00E-17 3 2.33E-17
3 SGTC_54 0159-0055 7.22 9.0 µM 2.19E-13 ERG2 16 2.63E-13
4 SGTC_1939 st074455 7.09 53.6 µM 5.70E-13 4 6.89E-13
5 SGTC_1383 3049-0032 5.54 20.7 µM 1.25E-8 60S ribosome export 3 1.53E-8
6 SGTC_436 n,n-dimethylsphingosine 5.39 3.3 µM 2.84E-8 8 3.48E-8
7 SGTC_1635 st007035 5.27 42.4 µM 5.51E-8 156 6.76E-8
8 SGTC_865 0488-0499 5.11 301.0 µM 1.33E-7 7 1.63E-7
9 SGTC_1966 st070145 4.90 16.1 µM 3.91E-7 10 4.78E-7
10 SGTC_2088 5278280 4.81 127.4 µM 6.13E-7 10 7.50E-7
11 SGTC_1193 1488-0126 4.66 41.5 µM 1.27E-6 16 1.56E-6
12 SGTC_2802 7925815 4.56 54.5 µM 2.11E-6 25 2.58E-6
13 SGTC_2615 purpurogallin-4-carboxylic acid 4.52 100.0 µM 2.55E-6 redox potentiating 47 3.11E-6
14 SGTC_3196 9111891 4.40 49.5 µM 4.46E-6 mitochondrial processes 13 5.43E-6
15 SGTC_1188 1403-0014 4.37 4.6 µM 5.05E-6 mitochondrial stress 39 6.15E-6
16 SGTC_908 3448-7491 4.35 47.7 µM 5.50E-6 mitochondrial stress 100 6.70E-6
17 SGTC_2546 rhodinyl acetate 4.01 100.0 µM 2.54E-5 12 3.08E-5
18 SGTC_386 1509-0011 3.88 3.1 µM 4.32E-5 148 5.22E-5
19 SGTC_1370 2001-0092 3.78 44.6 µM 6.56E-5 46 7.91E-5
20 SGTC_2912 7964298 3.60 10.9 µM 1.33E-4 cell wall 103 1.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.436 1.51E-155 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.424 4.20E-146 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.419 2.56E-142 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.408 7.81E-135 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.404 6.88E-132 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.400 2.32E-129 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.399 1.69E-128 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.389 1.22E-121 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.386 1.59E-119 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.383 6.49E-118 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.378 3.07E-114 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.377 8.70E-114 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.374 8.59E-112 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.374 9.96E-112 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.371 3.89E-110 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs