YCL058C / FYV5

Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL058C / FYV5

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:4.91|P-value:2.15E-6 ID:SGTC_57|Compound:miconazole|FD-Score:3.34|P-value:7.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.01|P-value:1.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.30|P-value:6.25E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.59|P-value:7.28E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.02|P-value:7.74E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:4.33|P-value:2.36E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-4.20|P-value:8.97E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.53|P-value:1.08E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.36|P-value:2.09E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-4.90|P-value:5.78E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.46|P-value:5.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.27|P-value:8.45E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-4.06|P-value:1.52E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-7.13|P-value:6.65E-11 ID:SGTC_1760|Compound:st045453|FD-Score:3.40|P-value:6.39E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.83|P-value:2.94E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.48|P-value:5.00E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.21|P-value:8.77E-5 ID:SGTC_1992|Compound:st073643|FD-Score:3.27|P-value:9.66E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.65|P-value:2.83E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.24|P-value:3.33E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.72|P-value:4.77E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.69|P-value:5.17E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.31|P-value:2.57E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.49|P-value:1.27E-5 ID:SGTC_2360|Compound:9040895|FD-Score:5.45|P-value:1.78E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.61|P-value:1.88E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-8.07|P-value:1.58E-13 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.59|P-value:3.44E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-5.00|P-value:3.78E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:9.56|P-value:4.14E-19 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.97|P-value:2.06E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.58|P-value:7.42E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.20|P-value:8.99E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.85|P-value:2.76E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.29|P-value:2.80E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.45|P-value:5.46E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.86|P-value:2.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.55|P-value:8.21E-4 ID:SGTC_2846|Compound:9008642|FD-Score:5.61|P-value:8.02E-8 ID:SGTC_2853|Compound:9015042|FD-Score:4.53|P-value:1.07E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.00|P-value:3.73E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-6.63|P-value:1.16E-9 ID:SGTC_2930|Compound:9013230|FD-Score:-3.67|P-value:5.61E-4 ID:SGTC_2940|Compound:9060638|FD-Score:7.70|P-value:4.26E-13 ID:SGTC_2964|Compound:9083345|FD-Score:3.47|P-value:5.17E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.58|P-value:3.64E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.19|P-value:9.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.82|P-value:3.42E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.84|P-value:3.22E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.91|P-value:2.15E-6 ID:SGTC_57|Compound:miconazole|FD-Score:3.34|P-value:7.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-4.01|P-value:1.79E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.30|P-value:6.25E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.59|P-value:7.28E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:4.02|P-value:7.74E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:4.33|P-value:2.36E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.56|P-value:3.85E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-4.20|P-value:8.97E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.53|P-value:1.08E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:4.36|P-value:2.09E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-4.90|P-value:5.78E-6 ID:SGTC_1609|Compound:st001574|FD-Score:3.46|P-value:5.31E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.27|P-value:8.45E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-4.06|P-value:1.52E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-7.13|P-value:6.65E-11 ID:SGTC_1760|Compound:st045453|FD-Score:3.40|P-value:6.39E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.83|P-value:2.94E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.48|P-value:5.00E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.21|P-value:8.77E-5 ID:SGTC_1992|Compound:st073643|FD-Score:3.27|P-value:9.66E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.65|P-value:2.83E-4 ID:SGTC_2107|Compound:5363541|FD-Score:4.24|P-value:3.33E-5 ID:SGTC_2273|Compound:7815444|FD-Score:4.72|P-value:4.77E-6 ID:SGTC_2276|Compound:7947513|FD-Score:-3.69|P-value:5.17E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.31|P-value:2.57E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.49|P-value:1.27E-5 ID:SGTC_2360|Compound:9040895|FD-Score:5.45|P-value:1.78E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.61|P-value:1.88E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-8.07|P-value:1.58E-13 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.59|P-value:3.44E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-5.00|P-value:3.78E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:9.56|P-value:4.14E-19 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.97|P-value:2.06E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.58|P-value:7.42E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.20|P-value:8.99E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.85|P-value:2.76E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.29|P-value:2.80E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.45|P-value:5.46E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.86|P-value:2.65E-6 ID:SGTC_2833|Compound:9001315|FD-Score:-3.55|P-value:8.21E-4 ID:SGTC_2846|Compound:9008642|FD-Score:5.61|P-value:8.02E-8 ID:SGTC_2853|Compound:9015042|FD-Score:4.53|P-value:1.07E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.00|P-value:3.73E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-6.63|P-value:1.16E-9 ID:SGTC_2930|Compound:9013230|FD-Score:-3.67|P-value:5.61E-4 ID:SGTC_2940|Compound:9060638|FD-Score:7.70|P-value:4.26E-13 ID:SGTC_2964|Compound:9083345|FD-Score:3.47|P-value:5.17E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.58|P-value:3.64E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.30|P-value:8.92E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-4.19|P-value:9.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.82|P-value:3.42E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.84|P-value:3.22E-4

Top fitness defect scores for YCL058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2578 7,8-dihydroxyflavone 9.56 64.4 µM 4.14E-19 3 6.06E-22
2 SGTC_2940 9060638 7.70 45.9 µM 4.26E-13 amide catabolism 1 6.96E-15
3 SGTC_2846 9008642 5.61 19.5 µM 8.02E-8 4 1.02E-8
4 SGTC_2360 9040895 5.45 200.0 µM 1.78E-7 RPP1 & pyrimidine depletion 7 2.57E-8
5 SGTC_33 0986-0033 4.91 35.8 µM 2.15E-6 calcium & mitochondrial duress 12 4.66E-7
6 SGTC_2688 kanamycin b 4.86 96.7 µM 2.65E-6 calcium & mitochondrial duress 259 5.92E-7
7 SGTC_2651 1327-0036 4.85 5.0 µM 2.76E-6 117 6.22E-7
8 SGTC_1781 st038725 4.83 66.3 µM 2.94E-6 NEO1 77 6.69E-7
9 SGTC_2273 7815444 4.72 169.1 µM 4.77E-6 12 1.17E-6
10 SGTC_2853 9015042 4.53 58.4 µM 1.07E-5 16 2.99E-6
11 SGTC_1389 3405-0187 4.53 19.0 µM 1.08E-5 8 3.00E-6
12 SGTC_2358 9037157 4.49 4.0 µM 1.27E-5 17 3.63E-6
13 SGTC_1474 0330-0125 4.36 5.3 µM 2.09E-5 20 6.46E-6
14 SGTC_862 0452-0056 4.33 10.2 µM 2.36E-5 azole & statin 29 7.44E-6
15 SGTC_2302 7771753 4.31 200.0 µM 2.57E-5 34 8.22E-6
16 SGTC_2658 polymyxin b sulfate 4.29 77.0 µM 2.80E-5 NEO1 35 9.07E-6
17 SGTC_2107 5363541 4.24 170.2 µM 3.33E-5 7 1.11E-5
18 SGTC_680 0417-1641 4.02 114.0 µM 7.74E-5 RPP1 & pyrimidine depletion 9 2.93E-5
19 SGTC_1920 st075728 3.75 45.7 µM 2.02E-4 26 8.85E-5
20 SGTC_1280 0880-0253 3.70 10.1 µM 2.43E-4 25 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.89E-14 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.129 7.06E-14 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.128 1.17E-13 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.115 2.29E-11 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1
0.115 2.56E-11 YGL218W_d YGL218W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
0.113 4.66E-11 YCR047C BUD23 hom Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.112 6.86E-11 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.111 1.25E-10 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.109 2.24E-10 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.108 3.58E-10 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.107 5.15E-10 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.107 5.42E-10 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.106 8.20E-10 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.106 8.00E-10 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.105 9.05E-10 YNL096C RPS7B hom Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress