YCL059C / KRR1

Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCL059C / KRR1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.41|P-value:8.06E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-2.88|P-value:9.19E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.91|P-value:1.11E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.12|P-value:2.74E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.90|P-value:8.42E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.87|P-value:3.71E-8 ID:SGTC_901|Compound:1112-0062|FD-Score:3.02|P-value:3.97E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.27|P-value:2.00E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.11|P-value:2.84E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.02|P-value:5.37E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.64|P-value:1.53E-7 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.26|P-value:1.51E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.06|P-value:3.47E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.85|P-value:7.66E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.02|P-value:5.35E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.81|P-value:1.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.87|P-value:9.39E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.06|P-value:3.50E-4 ID:SGTC_1773|Compound:st048542|FD-Score:2.92|P-value:5.89E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.90|P-value:3.80E-11 ID:SGTC_1953|Compound:st076800|FD-Score:3.75|P-value:1.66E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.25|P-value:1.32E-6 ID:SGTC_2141|Compound:5621638|FD-Score:2.85|P-value:7.71E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-3.76|P-value:2.18E-5 ID:SGTC_2158|Compound:5657123|FD-Score:5.24|P-value:3.58E-9 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-2.90|P-value:8.53E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.40|P-value:1.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.80|P-value:5.68E-8 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:6.16E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.77|P-value:1.49E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.59|P-value:4.99E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:2.81|P-value:9.21E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:2.83|P-value:8.38E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_2885|Compound:9057732|FD-Score:5.20|P-value:4.89E-9 ID:SGTC_2927|Compound:9011802|FD-Score:-4.18|P-value:2.81E-6 ID:SGTC_2941|Compound:9056145|FD-Score:-3.89|P-value:1.17E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.60|P-value:1.91E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-2.94|P-value:7.28E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.64|P-value:3.83E-5 ID:SGTC_3124|Compound:9127567|FD-Score:-3.32|P-value:1.62E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.06|P-value:3.48E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.78|P-value:1.42E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.01|P-value:1.55E-8 ID:SGTC_3208|Compound:9114115|FD-Score:3.84|P-value:1.05E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.81|P-value:1.27E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.53|P-value:4.64E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.06|P-value:3.48E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.35|P-value:7.64E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.08|P-value:3.24E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.67|P-value:3.42E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:3.41|P-value:8.06E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-2.88|P-value:9.19E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.91|P-value:1.11E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.12|P-value:2.74E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.90|P-value:8.42E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:4.87|P-value:3.71E-8 ID:SGTC_901|Compound:1112-0062|FD-Score:3.02|P-value:3.97E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.27|P-value:2.00E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.11|P-value:2.84E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.02|P-value:5.37E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.64|P-value:1.53E-7 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.26|P-value:1.51E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.06|P-value:3.47E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.85|P-value:7.66E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.02|P-value:5.35E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.81|P-value:1.78E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.87|P-value:9.39E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.06|P-value:3.50E-4 ID:SGTC_1773|Compound:st048542|FD-Score:2.92|P-value:5.89E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.90|P-value:3.80E-11 ID:SGTC_1953|Compound:st076800|FD-Score:3.75|P-value:1.66E-5 ID:SGTC_2061|Compound:5245884|FD-Score:4.25|P-value:1.32E-6 ID:SGTC_2141|Compound:5621638|FD-Score:2.85|P-value:7.71E-4 ID:SGTC_2150|Compound:5556613|FD-Score:-3.76|P-value:2.18E-5 ID:SGTC_2158|Compound:5657123|FD-Score:5.24|P-value:3.58E-9 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-2.90|P-value:8.53E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.40|P-value:1.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.80|P-value:5.68E-8 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.47|P-value:6.16E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.77|P-value:1.49E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.59|P-value:4.99E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:2.81|P-value:9.21E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:2.83|P-value:8.38E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.19|P-value:2.72E-4 ID:SGTC_2885|Compound:9057732|FD-Score:5.20|P-value:4.89E-9 ID:SGTC_2927|Compound:9011802|FD-Score:-4.18|P-value:2.81E-6 ID:SGTC_2941|Compound:9056145|FD-Score:-3.89|P-value:1.17E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.60|P-value:1.91E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-2.94|P-value:7.28E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.64|P-value:3.83E-5 ID:SGTC_3124|Compound:9127567|FD-Score:-3.32|P-value:1.62E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.06|P-value:3.48E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.78|P-value:1.42E-5 ID:SGTC_3188|Compound:9110789|FD-Score:5.01|P-value:1.55E-8 ID:SGTC_3208|Compound:9114115|FD-Score:3.84|P-value:1.05E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.81|P-value:1.27E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.53|P-value:4.64E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.06|P-value:3.48E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.35|P-value:7.64E-7 ID:SGTC_3290|Compound:9121031|FD-Score:3.08|P-value:3.24E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.67|P-value:3.42E-5

Top fitness defect scores for YCL059C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1919 st067113 5.90 52.3 µM 3.80E-11 TSC3-RPN4 4 1.80E-9 1.08
2 SGTC_2158 5657123 5.24 3.6 µM 3.58E-9 7 7.87E-8 0.52
3 SGTC_2885 9057732 5.20 52.0 µM 4.89E-9 2 1.02E-7 0.99
4 SGTC_3188 9110789 5.01 49.5 µM 1.55E-8 iron homeostasis 4 2.67E-7 0.09
5 SGTC_753 1322-0200 4.87 289.0 µM 3.71E-8 1 5.49E-7 1.13
6 SGTC_2428 5615643 4.80 7.8 µM 5.68E-8 5 7.84E-7 0.65
7 SGTC_1024 4507-0395 4.64 26.0 µM 1.53E-7 TSC3-RPN4 5 1.78E-6 0.05
8 SGTC_2970 9090938 4.60 41.9 µM 1.91E-7 RNA processing & uracil transport 6 2.15E-6 0.00
9 SGTC_3285 9112818 4.35 20.9 µM 7.64E-7 cell wall 11 6.80E-6 0.07
10 SGTC_2061 5245884 4.25 81.0 µM 1.32E-6 tubulin folding & SWR complex 5 1.07E-5 0.28
11 SGTC_1738 st035555 3.87 74.0 µM 9.39E-6 TSC3-RPN4 5 5.49E-5 0.10
12 SGTC_3208 9114115 3.84 49.5 µM 1.05E-5 15 6.03E-5 0.09
13 SGTC_3228 9131799 3.81 49.5 µM 1.27E-5 amide catabolism 3 7.08E-5 0.21
14 SGTC_3146 9095609 3.78 49.5 µM 1.42E-5 6 7.75E-5 0.07
15 SGTC_2488 5268135 3.77 45.7 µM 1.49E-5 8 8.04E-5 0.03
16 SGTC_1953 st076800 3.75 12.1 µM 1.66E-5 16 8.82E-5 0.13
17 SGTC_3232 9132874 3.53 49.5 µM 4.64E-5 RPP1 & pyrimidine depletion 13 2.08E-4 0.12
18 SGTC_2454 5-benzylidenerhodanine 3.47 10.4 µM 6.16E-5 TRP & mitochondrial translation 10 2.63E-4 0.06
19 SGTC_11 0438-0307 3.41 1.3 µM 8.06E-5 11 3.29E-4 0.04
20 SGTC_1054 3429-0080 3.26 167.0 µM 1.51E-4 12 5.55E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.88E-10 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.104 1.74E-9 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.097 1.85E-8 YPR129W SCD6 hom Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress
0.088 3.71E-7 YOL063C CRT10 hom Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat
0.087 5.15E-7 YGL003C CDH1 hom Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
0.080 3.47E-6 YDR045C RPC11 het RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
0.078 5.82E-6 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.077 8.92E-6 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.077 9.12E-6 YJR006W POL31 het Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair
0.076 1.01E-5 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.074 1.95E-5 YPL076W GPI2 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
0.073 2.10E-5 YFR038W IRC5 hom Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
0.072 2.90E-5 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.072 2.97E-5 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.072 3.33E-5 YPR186C PZF1 het Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA