YCL063W / VAC17

Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL063W / VAC17

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.24|P-value:9.59E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.78|P-value:1.50E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:7.27|P-value:2.43E-12 ID:SGTC_88|Compound:0180-0332|FD-Score:3.85|P-value:1.19E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.11|P-value:5.61E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:4.58|P-value:6.21E-6 ID:SGTC_229|Compound:benomyl|FD-Score:-3.70|P-value:2.58E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.86|P-value:1.78E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.74|P-value:1.75E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.32|P-value:1.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.61|P-value:2.76E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.48|P-value:5.63E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.39|P-value:1.38E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.05|P-value:5.55E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.27|P-value:8.75E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.05|P-value:7.46E-7 ID:SGTC_1616|Compound:st002734|FD-Score:4.33|P-value:1.84E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.81|P-value:1.37E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.22|P-value:2.77E-5 ID:SGTC_1891|Compound:st059073|FD-Score:5.96|P-value:6.80E-9 ID:SGTC_1897|Compound:st060201|FD-Score:-3.31|P-value:9.80E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.28|P-value:8.44E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.45|P-value:6.23E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.37|P-value:6.35E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.43|P-value:6.64E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.52|P-value:3.81E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.41|P-value:5.51E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.25|P-value:9.24E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.82|P-value:1.72E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.76|P-value:1.66E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-3.36|P-value:8.23E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.78|P-value:2.58E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.97|P-value:7.56E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.74|P-value:1.76E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.01|P-value:6.55E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:5.50|P-value:8.02E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.40|P-value:1.35E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.98|P-value:9.32E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.69|P-value:2.69E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.33|P-value:2.36E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.89|P-value:1.55E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.79|P-value:1.45E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.18|P-value:4.31E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.43|P-value:5.25E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.30|P-value:8.02E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.52|P-value:3.87E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.23|P-value:2.75E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.23|P-value:9.99E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.99|P-value:6.93E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.24|P-value:9.59E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.78|P-value:1.50E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:7.27|P-value:2.43E-12 ID:SGTC_88|Compound:0180-0332|FD-Score:3.85|P-value:1.19E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.11|P-value:5.61E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:4.58|P-value:6.21E-6 ID:SGTC_229|Compound:benomyl|FD-Score:-3.70|P-value:2.58E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.86|P-value:1.78E-6 ID:SGTC_611|Compound:3453-1652|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.74|P-value:1.75E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:4.32|P-value:1.84E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.86|P-value:1.12E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.61|P-value:2.76E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.48|P-value:5.63E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.39|P-value:1.38E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:4.05|P-value:5.55E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.27|P-value:8.75E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:5.05|P-value:7.46E-7 ID:SGTC_1616|Compound:st002734|FD-Score:4.33|P-value:1.84E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.81|P-value:1.37E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.22|P-value:2.77E-5 ID:SGTC_1891|Compound:st059073|FD-Score:5.96|P-value:6.80E-9 ID:SGTC_1897|Compound:st060201|FD-Score:-3.31|P-value:9.80E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.28|P-value:8.44E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.45|P-value:6.23E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.37|P-value:6.35E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.76|P-value:1.65E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.43|P-value:6.64E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.52|P-value:3.81E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.41|P-value:5.51E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.25|P-value:9.24E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.82|P-value:1.72E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.76|P-value:1.66E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-3.36|P-value:8.23E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.78|P-value:2.58E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.97|P-value:7.56E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.74|P-value:1.76E-4 ID:SGTC_2534|Compound:helenine|FD-Score:4.01|P-value:6.55E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:5.50|P-value:8.02E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.40|P-value:1.35E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:-3.98|P-value:9.32E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.69|P-value:2.69E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.33|P-value:2.36E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.89|P-value:1.55E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.79|P-value:1.45E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.18|P-value:4.31E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.43|P-value:5.25E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.30|P-value:8.02E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.52|P-value:3.87E-4 ID:SGTC_3030|Compound:9087619|FD-Score:4.23|P-value:2.75E-5 ID:SGTC_3138|Compound:9097216|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.23|P-value:9.99E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.99|P-value:6.93E-5

Top fitness defect scores for YCL063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_87 0100-0052 7.27 35.5 µM 2.43E-12 18 1.86E-13
2 SGTC_1891 st059073 5.96 26.2 µM 6.80E-9 TSC3-RPN4 6 1.23E-9
3 SGTC_2668 2',4'-dihydroxychalcone 5.50 15.1 µM 8.02E-8 3 1.88E-8
4 SGTC_90 0870-0863 5.11 4.6 µM 5.61E-7 19 1.62E-7
5 SGTC_1576 erythromycin ethylsuccinate 5.05 23.2 µM 7.46E-7 7 2.22E-7
6 SGTC_2775 cyproheptadine 4.89 69.6 µM 1.55E-6 6 4.97E-7
7 SGTC_594 1487-1584 4.86 10.8 µM 1.78E-6 12 5.78E-7
8 SGTC_2479 5617353 4.78 43.9 µM 2.58E-6 15 8.73E-7
9 SGTC_177 1327-0068 4.58 8.4 µM 6.21E-6 36 2.30E-6
10 SGTC_2679 rapamycin 4.40 1.0 nM 1.35E-5 122 5.41E-6
11 SGTC_1258 0671-0043 4.39 57.1 µM 1.38E-5 15 5.57E-6
12 SGTC_1616 st002734 4.33 56.1 µM 1.84E-5 22 7.62E-6
13 SGTC_985 1493-0307 4.32 8.7 µM 1.84E-5 TSC3-RPN4 19 7.64E-6
14 SGTC_3030 9087619 4.23 49.5 µM 2.75E-5 6 1.19E-5
15 SGTC_1768 st044301 4.22 37.2 µM 2.77E-5 14 1.20E-5
16 SGTC_1473 k844-0725 4.05 134.0 µM 5.55E-5 10 2.58E-5
17 SGTC_2534 helenine 4.01 20.1 µM 6.55E-5 RSC complex & mRNA processing 15 3.09E-5
18 SGTC_3317 9138495 3.99 8.8 µM 6.93E-5 34 3.29E-5
19 SGTC_2526 patulin 3.97 37.6 µM 7.56E-5 90 3.62E-5
20 SGTC_1024 4507-0395 3.86 26.0 µM 1.12E-4 TSC3-RPN4 31 5.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.23E-23 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.165 6.64E-22 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.153 4.66E-19 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.152 9.94E-19 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.147 1.01E-17 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.143 6.58E-17 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.137 1.28E-15 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.128 9.58E-14 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.124 5.58E-13 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.123 9.75E-13 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.113 5.46E-11 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.111 1.22E-10 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.107 4.68E-10 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.105 1.00E-9 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.102 3.29E-9 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication