YCL064C / CHA1

Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL064C / CHA1

Click on Significant Values for Screen Details ID:SGTC_362|Compound:0310-0100|FD-Score:4.32|P-value:7.21E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.08|P-value:9.75E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.31|P-value:4.51E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:4.17|P-value:1.38E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.48|P-value:2.33E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.96|P-value:2.92E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.13|P-value:8.42E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.33|P-value:4.12E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.18|P-value:6.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.50|P-value:2.21E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.40|P-value:3.14E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.43|P-value:2.68E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.39|P-value:3.29E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.97|P-value:2.93E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-7.43|P-value:3.47E-14 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.25|P-value:9.84E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:7.12|P-value:4.06E-13 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.29|P-value:4.79E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.28|P-value:5.54E-8 ID:SGTC_3029|Compound:9088683|FD-Score:4.56|P-value:2.26E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.09|P-value:2.01E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.98|P-value:3.21E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.75|P-value:9.02E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-3.31|P-value:4.16E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.56|P-value:1.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.42|P-value:4.16E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:4.32|P-value:7.21E-6 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.08|P-value:9.75E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:3.31|P-value:4.51E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:4.17|P-value:1.38E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.48|P-value:2.33E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.96|P-value:2.92E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.13|P-value:8.42E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.65|P-value:1.22E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.33|P-value:4.12E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.18|P-value:6.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.50|P-value:2.21E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.40|P-value:3.14E-4 ID:SGTC_2102|Compound:5377816|FD-Score:-3.43|P-value:2.68E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.39|P-value:3.29E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.97|P-value:2.93E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.25|P-value:5.45E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-7.43|P-value:3.47E-14 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.25|P-value:9.84E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:7.12|P-value:4.06E-13 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.29|P-value:4.79E-4 ID:SGTC_2834|Compound:9001755|FD-Score:5.28|P-value:5.54E-8 ID:SGTC_3029|Compound:9088683|FD-Score:4.56|P-value:2.26E-6 ID:SGTC_3043|Compound:9092303|FD-Score:4.09|P-value:2.01E-5 ID:SGTC_3062|Compound:9077494|FD-Score:3.98|P-value:3.21E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.75|P-value:9.02E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-3.31|P-value:4.16E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.56|P-value:1.76E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.42|P-value:4.16E-6

Top fitness defect scores for YCL064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2584 androsterone 7.12 48.7 µM 4.06E-13 cell wall 36 5.41E-13
2 SGTC_2834 9001755 5.28 58.4 µM 5.54E-8 13 6.44E-8
3 SGTC_2400 5203494 4.97 178.7 µM 2.93E-7 RSC complex & mRNA processing 12 3.34E-7
4 SGTC_3197 9113331 4.75 49.5 µM 9.02E-7 22 1.02E-6
5 SGTC_3029 9088683 4.56 49.5 µM 2.26E-6 15 2.52E-6
6 SGTC_362 0310-0100 4.32 9.0 µM 7.21E-6 RPP1 & pyrimidine depletion 25 7.94E-6
7 SGTC_2539 epi(13)torulosol 4.25 80.0 µM 9.84E-6 21 1.08E-5
8 SGTC_678 1218-2179 4.17 85.9 µM 1.38E-5 RNA pol III & RNase P/MRP 3 1.51E-5
9 SGTC_3043 9092303 4.09 49.5 µM 2.01E-5 13 2.18E-5
10 SGTC_3062 9077494 3.98 49.5 µM 3.21E-5 mitochondrial response to ROS 35 3.47E-5
11 SGTC_3193 9111931 3.66 49.5 µM 1.17E-4 31 1.25E-4
12 SGTC_1492 4158-0558 3.65 28.5 µM 1.22E-4 60S ribosome export 20 1.30E-4
13 SGTC_1702 st027038 3.63 51.0 µM 1.34E-4 20 1.43E-4
14 SGTC_1039 k821-0043 3.62 94.0 µM 1.39E-4 Golgi 41 1.48E-4
15 SGTC_3208 9114115 3.56 49.5 µM 1.76E-4 57 1.88E-4
16 SGTC_411 enrofloxacin 3.54 100.0 µM 1.87E-4 DNA damage response 16 1.98E-4
17 SGTC_1917 st066507 3.50 28.5 µM 2.21E-4 Golgi 58 2.35E-4
18 SGTC_690 glyoxal 3.48 20.3 µM 2.33E-4 105 2.47E-4
19 SGTC_1930 st074634 3.40 34.3 µM 3.14E-4 RNA pol III & RNase P/MRP 55 3.32E-4
20 SGTC_2377 9073351 3.39 62.6 µM 3.29E-4 ergosterol biosynthesis 39 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.38E-17 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.89E-13 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.123 7.07E-13 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.123 7.55E-13 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.118 6.84E-12 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.111 1.17E-10 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
0.110 1.49E-10 YMR001C CDC5 het Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
0.100 5.60E-9 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.100 6.36E-9 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.097 1.74E-8 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.097 2.10E-8 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.096 2.26E-8 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.096 2.81E-8 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.094 4.49E-8 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.093 6.05E-8 YMR275C BUL1 hom Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication