YCL075W

Pseudogene: encodes fragment of Ty Pol protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL075W / YCL075W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.40|P-value:9.67E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.26|P-value:1.52E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:2.91|P-value:7.11E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.22|P-value:2.11E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.00|P-value:5.22E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.42|P-value:9.49E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-2.90|P-value:7.74E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.41|P-value:9.99E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.02|P-value:5.43E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:4.30|P-value:1.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.14|P-value:2.89E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.07|P-value:4.08E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.86|P-value:1.20E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.30|P-value:1.48E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.96|P-value:3.09E-8 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.41|P-value:9.74E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.19|P-value:2.49E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.01|P-value:6.13E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.87|P-value:5.23E-8 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.49|P-value:7.01E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.85|P-value:8.98E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.75|P-value:2.10E-5 ID:SGTC_1729|Compound:st035615|FD-Score:4.48|P-value:4.60E-7 ID:SGTC_1762|Compound:st045503|FD-Score:2.89|P-value:7.68E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.63|P-value:2.01E-7 ID:SGTC_1980|Compound:st071811|FD-Score:3.08|P-value:3.64E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-2.94|P-value:6.69E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.43|P-value:8.95E-5 ID:SGTC_2020|Compound:4017018|FD-Score:2.87|P-value:8.29E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.95|P-value:3.62E-11 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.11|P-value:3.30E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.60|P-value:4.04E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.65|P-value:3.46E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.87|P-value:4.80E-8 ID:SGTC_2385|Compound:9074692|FD-Score:-3.01|P-value:5.07E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.41|P-value:7.24E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.17|P-value:2.59E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.83|P-value:9.72E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.03|P-value:4.49E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.80|P-value:1.57E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.55|P-value:3.08E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.87|P-value:8.37E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.95|P-value:1.43E-14 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.98|P-value:5.49E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.23|P-value:2.01E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.18|P-value:2.41E-6 ID:SGTC_2907|Compound:7721985|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.95|P-value:8.25E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.00|P-value:5.07E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.06|P-value:1.53E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.01|P-value:5.71E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-2.88|P-value:8.48E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.89|P-value:1.04E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.23|P-value:2.13E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.31|P-value:1.16E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.09|P-value:3.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.40|P-value:9.67E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.26|P-value:1.52E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:2.91|P-value:7.11E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.22|P-value:2.11E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.00|P-value:5.22E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.42|P-value:9.49E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:-2.90|P-value:7.74E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.41|P-value:9.99E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.02|P-value:5.43E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:4.30|P-value:1.25E-6 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.14|P-value:2.89E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.07|P-value:4.08E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.86|P-value:1.20E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.34|P-value:1.25E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.30|P-value:1.48E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-4.96|P-value:3.09E-8 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.41|P-value:9.74E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.19|P-value:2.49E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.01|P-value:6.13E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.87|P-value:5.23E-8 ID:SGTC_1466|Compound:k213-0079|FD-Score:-3.49|P-value:7.01E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.85|P-value:8.98E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.75|P-value:2.10E-5 ID:SGTC_1729|Compound:st035615|FD-Score:4.48|P-value:4.60E-7 ID:SGTC_1762|Compound:st045503|FD-Score:2.89|P-value:7.68E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.63|P-value:2.01E-7 ID:SGTC_1980|Compound:st071811|FD-Score:3.08|P-value:3.64E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-2.94|P-value:6.69E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.43|P-value:8.95E-5 ID:SGTC_2020|Compound:4017018|FD-Score:2.87|P-value:8.29E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.95|P-value:3.62E-11 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.11|P-value:3.30E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.60|P-value:4.04E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-3.65|P-value:3.46E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.87|P-value:4.80E-8 ID:SGTC_2385|Compound:9074692|FD-Score:-3.01|P-value:5.07E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.41|P-value:7.24E-7 ID:SGTC_2448|Compound:5185112|FD-Score:3.17|P-value:2.59E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.83|P-value:9.72E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.03|P-value:4.49E-4 ID:SGTC_2464|Compound:5717415|FD-Score:3.77|P-value:1.87E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.80|P-value:1.57E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:4.55|P-value:3.08E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:2.87|P-value:8.37E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:6.95|P-value:1.43E-14 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.98|P-value:5.49E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.23|P-value:2.01E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:4.18|P-value:2.41E-6 ID:SGTC_2907|Compound:7721985|FD-Score:-3.39|P-value:1.08E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.95|P-value:8.25E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.00|P-value:5.07E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.06|P-value:1.53E-8 ID:SGTC_2971|Compound:9092186|FD-Score:4.01|P-value:5.71E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-2.88|P-value:8.48E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.89|P-value:1.04E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.23|P-value:2.13E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.31|P-value:1.16E-6 ID:SGTC_3285|Compound:9112818|FD-Score:-3.09|P-value:3.68E-4

Top fitness defect scores for YCL075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2690 usnic acid 6.95 100.0 µM 1.43E-14 2 1.82E-12
2 SGTC_2125 5246583 5.95 200.0 µM 3.62E-11 tubulin folding & SWR complex 16 1.31E-9
3 SGTC_2927 9011802 5.06 47.9 µM 1.53E-8 11 2.10E-7
4 SGTC_2366 9070441 4.87 60.6 µM 4.80E-8 13 5.48E-7
5 SGTC_1845 st056753 4.63 3.0 µM 2.01E-7 TSC3-RPN4 22 1.83E-6
6 SGTC_2533 agelasine 4.55 13.7 µM 3.08E-7 ERG2 36 2.62E-6
7 SGTC_1729 st035615 4.48 46.0 µM 4.60E-7 22 3.67E-6
8 SGTC_3080 9117754 4.31 49.5 µM 1.16E-6 10 8.00E-6
9 SGTC_961 1252-1571 4.30 372.0 µM 1.25E-6 24 8.51E-6
10 SGTC_69 0096-0274 4.26 206.7 µM 1.52E-6 mitochondrial processes 31 1.00E-5
11 SGTC_2771 fluoxetine 4.18 41.0 µM 2.41E-6 15 1.48E-5
12 SGTC_1370 2001-0092 4.07 44.6 µM 4.08E-6 28 2.31E-5
13 SGTC_960 1222-0186 4.02 7.7 µM 5.43E-6 33 2.93E-5
14 SGTC_2971 9092186 4.01 9.9 µM 5.71E-6 ergosterol biosynthesis 32 3.06E-5
15 SGTC_3057 9095946 3.89 49.5 µM 1.04E-5 Golgi 16 5.09E-5
16 SGTC_1374 2889-5571 3.86 141.0 µM 1.20E-5 RSC complex & mRNA processing 42 5.72E-5
17 SGTC_2522 biochanin a 3.80 4.9 µM 1.57E-5 RNA pol III & RNase P/MRP 13 7.16E-5
18 SGTC_2464 5717415 3.77 7.7 µM 1.87E-5 20 8.30E-5
19 SGTC_2136 5328288 3.60 199.3 µM 4.04E-5 27 1.59E-4
20 SGTC_64 000l-0018 3.40 272.1 µM 9.67E-5 ubiquinone biosynthesis & proteasome 184 3.32E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.261 2.16E-53 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.173 4.78E-24 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.165 5.04E-22 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.162 4.24E-21 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.158 2.94E-20 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.158 4.46E-20 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.150 2.66E-18 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.146 2.12E-17 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.144 5.36E-17 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.141 2.39E-16 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.136 2.47E-15 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135 3.42E-15 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
0.135 3.60E-15 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.131 3.35E-14 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.127 1.40E-13 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication