YCR001W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR001W / YCR001W

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:3.03|P-value:5.85E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.70|P-value:4.25E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:2.98|P-value:6.96E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.63|P-value:5.10E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.67|P-value:4.23E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:4.61|P-value:4.34E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:4.63|P-value:3.79E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:4.17|P-value:4.28E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.14|P-value:3.80E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.60|P-value:5.75E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.41|P-value:1.87E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.07|P-value:5.00E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.40|P-value:1.33E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.93|P-value:1.34E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-4.17|P-value:6.29E-6 ID:SGTC_2031|Compound:5180455|FD-Score:-3.51|P-value:1.21E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.16|P-value:1.91E-8 ID:SGTC_2095|Compound:5432005|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.07|P-value:6.78E-6 ID:SGTC_2172|Compound:5754775|FD-Score:5.04|P-value:3.86E-8 ID:SGTC_2175|Compound:5807670|FD-Score:3.73|P-value:3.37E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.20|P-value:4.19E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.07|P-value:4.96E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.53|P-value:1.02E-6 ID:SGTC_2348|Compound:9022543|FD-Score:-3.26|P-value:3.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.86|P-value:2.21E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.73|P-value:2.20E-7 ID:SGTC_2449|Compound:5812982|FD-Score:-3.20|P-value:4.26E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.04|P-value:7.64E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.88|P-value:1.65E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.72|P-value:3.44E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.80|P-value:2.41E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.02|P-value:5.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.20|P-value:5.44E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.15|P-value:4.99E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-4.13|P-value:7.65E-6 ID:SGTC_3182|Compound:9108849|FD-Score:-3.03|P-value:7.81E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.03|P-value:5.85E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.70|P-value:4.25E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:2.98|P-value:6.96E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.63|P-value:5.10E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:3.13|P-value:4.00E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.67|P-value:4.23E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:4.61|P-value:4.34E-7 ID:SGTC_729|Compound:4092-0585|FD-Score:4.63|P-value:3.79E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:4.17|P-value:4.28E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:3.14|P-value:3.80E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.60|P-value:5.75E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.41|P-value:1.87E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.07|P-value:5.00E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.40|P-value:1.33E-6 ID:SGTC_1634|Compound:st006576|FD-Score:3.93|P-value:1.34E-5 ID:SGTC_1826|Compound:st055655|FD-Score:-4.17|P-value:6.29E-6 ID:SGTC_2031|Compound:5180455|FD-Score:-3.51|P-value:1.21E-4 ID:SGTC_2063|Compound:5246145|FD-Score:5.16|P-value:1.91E-8 ID:SGTC_2095|Compound:5432005|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:4.07|P-value:6.78E-6 ID:SGTC_2172|Compound:5754775|FD-Score:5.04|P-value:3.86E-8 ID:SGTC_2175|Compound:5807670|FD-Score:3.73|P-value:3.37E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.20|P-value:4.19E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.07|P-value:4.96E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.53|P-value:1.02E-6 ID:SGTC_2348|Compound:9022543|FD-Score:-3.26|P-value:3.29E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.86|P-value:2.21E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.73|P-value:2.20E-7 ID:SGTC_2449|Compound:5812982|FD-Score:-3.20|P-value:4.26E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.04|P-value:7.64E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.88|P-value:1.65E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.72|P-value:3.44E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.80|P-value:2.41E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.02|P-value:5.95E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.20|P-value:5.44E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.15|P-value:4.99E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-4.13|P-value:7.65E-6 ID:SGTC_3182|Compound:9108849|FD-Score:-3.03|P-value:7.81E-4

Top fitness defect scores for YCR001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 5.86 3.5 µM 2.21E-10 31 2.38E-9
2 SGTC_2063 5246145 5.16 200.0 µM 1.91E-8 10 1.26E-7
3 SGTC_2172 5754775 5.04 163.9 µM 3.86E-8 6 2.35E-7
4 SGTC_2420 aureobasidin a 4.73 50.0 nM 2.20E-7 25 1.11E-6
5 SGTC_729 4092-0585 4.63 94.1 µM 3.79E-7 12 1.80E-6
6 SGTC_718 1130-0073 4.61 349.0 µM 4.34E-7 9 2.03E-6
7 SGTC_1368 1852-0141 4.40 284.0 µM 1.33E-6 ERG2 31 5.51E-6
8 SGTC_805 3852-0218 4.17 479.0 µM 4.28E-6 ERAD & cell cycle 63 1.55E-5
9 SGTC_2170 morpholine 4.07 200.0 µM 6.78E-6 8 2.34E-5
10 SGTC_1634 st006576 3.93 41.0 µM 1.34E-5 TSC3-RPN4 21 4.28E-5
11 SGTC_2463 5473429 3.88 200.0 µM 1.65E-5 ERG2 17 5.18E-5
12 SGTC_1226 3909-7979 3.85 35.4 µM 1.88E-5 40 5.80E-5
13 SGTC_2788 5282734 3.81 71.4 µM 2.33E-5 55 7.03E-5
14 SGTC_2473 5854593 3.80 8.9 µM 2.41E-5 13 7.23E-5
15 SGTC_2175 5807670 3.73 165.3 µM 3.37E-5 24 9.76E-5
16 SGTC_2468 5987765 3.72 72.9 µM 3.44E-5 20 9.92E-5
17 SGTC_716 1683-5115 3.67 658.0 µM 4.23E-5 32 1.19E-4
18 SGTC_567 1080-0542 3.63 68.4 µM 5.10E-5 18 1.41E-4
19 SGTC_842 0271-0008 3.60 11.1 µM 5.75E-5 heme biosynthesis & mitochondrial translocase 29 1.57E-4
20 SGTC_2454 5-benzylidenerhodanine 3.42 10.4 µM 1.23E-4 TRP & mitochondrial translation 67 3.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.43E-35 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.124 5.98E-13 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.115 2.43E-11 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.104 1.47E-9 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.103 2.32E-9 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.097 1.92E-8 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.097 1.98E-8 YFR036W CDC26 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.093 6.21E-8 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.091 1.14E-7 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.091 1.19E-7 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.088 2.95E-7 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.084 9.71E-7 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.084 1.08E-6 YDR126W SWF1 hom Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
0.083 1.70E-6 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.078 6.75E-6 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes