YCR002C / CDC10

Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR002C / CDC10

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:8.56E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.28|P-value:1.94E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:3.51|P-value:7.38E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.89|P-value:2.10E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.08|P-value:1.06E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.63|P-value:4.96E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:7.01|P-value:9.53E-11 ID:SGTC_706|Compound:4262-0057|FD-Score:3.67|P-value:4.40E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.45|P-value:8.95E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.08|P-value:1.98E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:4.59|P-value:1.54E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.83|P-value:2.58E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.82|P-value:2.70E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.97|P-value:1.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.15|P-value:8.34E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.46|P-value:2.62E-5 ID:SGTC_1610|Compound:st001799|FD-Score:4.88|P-value:4.83E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.20|P-value:6.95E-5 ID:SGTC_2173|Compound:5763948|FD-Score:5.54|P-value:2.52E-7 ID:SGTC_2243|Compound:6634756|FD-Score:4.37|P-value:3.62E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.83|P-value:5.94E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.27|P-value:5.28E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-4.02|P-value:1.23E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.09|P-value:1.05E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.51|P-value:7.36E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.85|P-value:2.42E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.99|P-value:1.34E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:9.41|P-value:6.25E-18 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.83|P-value:2.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.65|P-value:4.73E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.33|P-value:4.24E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.93|P-value:3.83E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.80|P-value:2.88E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.49|P-value:7.82E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.61|P-value:4.87E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.50|P-value:7.61E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.72|P-value:3.68E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.75|P-value:3.38E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.42|P-value:9.61E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.54|P-value:1.92E-5 ID:SGTC_3095|Compound:9117207|FD-Score:3.51|P-value:7.26E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.91|P-value:1.84E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.17|P-value:7.70E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:8.56E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.28|P-value:1.94E-11 ID:SGTC_351|Compound:caspofungin|FD-Score:3.51|P-value:7.38E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.89|P-value:2.10E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.08|P-value:1.06E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.63|P-value:4.96E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:7.01|P-value:9.53E-11 ID:SGTC_706|Compound:4262-0057|FD-Score:3.67|P-value:4.40E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:3.45|P-value:8.95E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:5.08|P-value:1.98E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:4.59|P-value:1.54E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.83|P-value:2.58E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.82|P-value:2.70E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.97|P-value:1.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.15|P-value:8.34E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.46|P-value:2.62E-5 ID:SGTC_1610|Compound:st001799|FD-Score:4.88|P-value:4.83E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.20|P-value:6.95E-5 ID:SGTC_2173|Compound:5763948|FD-Score:5.54|P-value:2.52E-7 ID:SGTC_2243|Compound:6634756|FD-Score:4.37|P-value:3.62E-5 ID:SGTC_2313|Compound:7726885|FD-Score:4.83|P-value:5.94E-6 ID:SGTC_2323|Compound:6148992|FD-Score:4.27|P-value:5.28E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-4.02|P-value:1.23E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.09|P-value:1.05E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.51|P-value:7.36E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.85|P-value:2.42E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.99|P-value:1.34E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:9.41|P-value:6.25E-18 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.83|P-value:2.56E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.65|P-value:4.73E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.33|P-value:4.24E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.93|P-value:3.83E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.80|P-value:2.88E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.49|P-value:7.82E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.61|P-value:4.87E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.50|P-value:7.61E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.72|P-value:3.68E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.75|P-value:3.38E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.42|P-value:9.61E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.54|P-value:1.92E-5 ID:SGTC_3095|Compound:9117207|FD-Score:3.51|P-value:7.26E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.91|P-value:1.84E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.17|P-value:7.70E-5

Top fitness defect scores for YCR002C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2501 sodium tetradecyl sulfate 9.41 13.4 µM 6.25E-18 2 2.47E-21
2 SGTC_138 0850-0259 7.28 40.9 µM 1.94E-11 cell wall 71 1.70E-13
3 SGTC_696 1560-0013 7.01 611.0 µM 9.53E-11 2 1.16E-12
4 SGTC_2173 5763948 5.54 167.0 µM 2.52E-7 tubulin folding & SWR complex 7 1.54E-8
5 SGTC_785 1270-0111 5.08 65.3 µM 1.98E-6 8 1.85E-7
6 SGTC_2617 dihydrotanshinone i 4.93 20.8 µM 3.83E-6 copper-dependent oxidative stress 15 4.09E-7
7 SGTC_1610 st001799 4.88 48.1 µM 4.83E-6 4 5.40E-7
8 SGTC_2313 7726885 4.83 200.0 µM 5.94E-6 RPP1 & pyrimidine depletion 17 6.93E-7
9 SGTC_58 0957-0393 4.74 9.0 µM 8.56E-6 cell wall 313 1.08E-6
10 SGTC_787 4152-0075 4.59 138.0 µM 1.54E-5 11 2.17E-6
11 SGTC_2989 9073649 4.54 71.4 µM 1.92E-5 21 2.83E-6
12 SGTC_1265 0819-1001 4.46 68.8 µM 2.62E-5 14 4.12E-6
13 SGTC_2243 6634756 4.37 200.0 µM 3.62E-5 15 6.08E-6
14 SGTC_2613 3',4'-dimethoxydalbergione 4.33 24.6 µM 4.24E-5 14 7.35E-6
15 SGTC_2323 6148992 4.27 148.3 µM 5.28E-5 26 9.56E-6
16 SGTC_1785 bathophenanthroline 4.20 24.0 µM 6.95E-5 heme requiring 40 1.33E-5
17 SGTC_3245 9134821 4.17 49.5 µM 7.70E-5 13 1.51E-5
18 SGTC_1159 4092-0538 4.15 61.2 µM 8.34E-5 23 1.66E-5
19 SGTC_2400 5203494 4.09 178.7 µM 1.05E-4 RSC complex & mRNA processing 23 2.17E-5
20 SGTC_366 0181-0206 4.08 4.3 µM 1.06E-4 Golgi 35 2.22E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 4.18E-24 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.166 4.36E-22 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.156 1.14E-19 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.146 1.61E-17 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.146 1.65E-17 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.143 7.21E-17 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.142 1.28E-16 YJL163C_p YJL163C_p hom Putative protein of unknown function
0.139 6.39E-16 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.137 1.96E-15 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.136 2.07E-15 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.135 3.37E-15 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 5.51E-15 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.134 7.45E-15 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.133 1.11E-14 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.132 1.85E-14 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria