YCR004C / YCP4

Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR004C / YCP4

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.13|P-value:7.17E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.05|P-value:8.33E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.27|P-value:4.28E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.09|P-value:8.05E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.15|P-value:9.80E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.34|P-value:3.31E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.15|P-value:6.00E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.11|P-value:6.75E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.56|P-value:1.39E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:7.19|P-value:7.86E-14 ID:SGTC_870|Compound:0573-2213|FD-Score:-6.54|P-value:1.14E-11 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.24|P-value:4.75E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.76|P-value:5.49E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.18|P-value:5.26E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.01|P-value:9.60E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.78|P-value:4.97E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.20|P-value:4.89E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.02|P-value:9.37E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.45|P-value:2.44E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.14|P-value:6.06E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.03|P-value:9.16E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.20|P-value:5.48E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.77|P-value:5.24E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.19|P-value:5.10E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.69|P-value:7.43E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.07|P-value:7.82E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.37|P-value:2.60E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.12|P-value:6.57E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.71|P-value:6.70E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.63|P-value:9.37E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.09|P-value:7.33E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.63|P-value:9.37E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.19|P-value:8.17E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:12.60|P-value:1.06E-38 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.32|P-value:4.33E-11 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.26|P-value:6.73E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:-7.85|P-value:4.98E-16 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.32|P-value:3.51E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.69|P-value:8.44E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.28|P-value:6.25E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.67|P-value:2.96E-9 ID:SGTC_2912|Compound:7964298|FD-Score:-3.19|P-value:5.73E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.38|P-value:2.57E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.19|P-value:5.79E-4 ID:SGTC_3125|Compound:9127534|FD-Score:5.08|P-value:8.90E-8 ID:SGTC_3129|Compound:9127257|FD-Score:-4.23|P-value:8.00E-6 ID:SGTC_3142|Compound:9086498|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_3154|Compound:9100113|FD-Score:5.38|P-value:1.63E-8 ID:SGTC_3157|Compound:9099274|FD-Score:4.25|P-value:6.20E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.44|P-value:2.27E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.93|P-value:5.57E-10 ID:SGTC_3335|Compound:9143315|FD-Score:-3.65|P-value:1.00E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.13|P-value:7.17E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.05|P-value:8.33E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.27|P-value:4.28E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.09|P-value:8.05E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.15|P-value:9.80E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.34|P-value:3.31E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.15|P-value:6.00E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.40|P-value:2.32E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.11|P-value:6.75E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:4.56|P-value:1.39E-6 ID:SGTC_869|Compound:0564-0080|FD-Score:7.19|P-value:7.86E-14 ID:SGTC_870|Compound:0573-2213|FD-Score:-6.54|P-value:1.14E-11 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.24|P-value:4.75E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.76|P-value:5.49E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:3.18|P-value:5.26E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.01|P-value:9.60E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.78|P-value:4.97E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.20|P-value:4.89E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.02|P-value:9.37E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.45|P-value:2.44E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.14|P-value:6.06E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.03|P-value:9.16E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.20|P-value:5.48E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.77|P-value:5.24E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.19|P-value:5.10E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.69|P-value:7.43E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.07|P-value:7.82E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.37|P-value:2.60E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.19|P-value:5.14E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.12|P-value:6.57E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.71|P-value:6.70E-5 ID:SGTC_2142|Compound:5622915|FD-Score:3.63|P-value:9.37E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.09|P-value:7.33E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.63|P-value:9.37E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.19|P-value:8.17E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:12.60|P-value:1.06E-38 ID:SGTC_2594|Compound:a-mangostin|FD-Score:6.32|P-value:4.33E-11 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.26|P-value:6.73E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:-7.85|P-value:4.98E-16 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.32|P-value:3.51E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.69|P-value:8.44E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.28|P-value:6.25E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.67|P-value:2.96E-9 ID:SGTC_2912|Compound:7964298|FD-Score:-3.19|P-value:5.73E-4 ID:SGTC_2954|Compound:9074818|FD-Score:3.38|P-value:2.57E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.19|P-value:5.79E-4 ID:SGTC_3125|Compound:9127534|FD-Score:5.08|P-value:8.90E-8 ID:SGTC_3129|Compound:9127257|FD-Score:-4.23|P-value:8.00E-6 ID:SGTC_3142|Compound:9086498|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_3154|Compound:9100113|FD-Score:5.38|P-value:1.63E-8 ID:SGTC_3157|Compound:9099274|FD-Score:4.25|P-value:6.20E-6 ID:SGTC_3323|Compound:9138564|FD-Score:-3.44|P-value:2.27E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.93|P-value:5.57E-10 ID:SGTC_3335|Compound:9143315|FD-Score:-3.65|P-value:1.00E-4

Top fitness defect scores for YCR004C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2593 nobiletin 12.60 86.2 µM 1.06E-38 2 6.83E-37
2 SGTC_869 0564-0080 7.19 44.1 µM 7.86E-14 1 3.24E-13
3 SGTC_2594 a-mangostin 6.32 100.0 µM 4.33E-11 8 1.32E-10
4 SGTC_3333 9141820 5.93 12.1 µM 5.57E-10 4 1.50E-9
5 SGTC_2697 mebhydrolin 5.67 72.4 µM 2.96E-9 NEO1 35 7.34E-9
6 SGTC_3154 9100113 5.38 49.5 µM 1.63E-8 10 3.73E-8
7 SGTC_3125 9127534 5.08 49.5 µM 8.90E-8 3 1.87E-7
8 SGTC_857 0438-0306 4.56 1.4 µM 1.39E-6 copper-dependent oxidative stress 4 2.56E-6
9 SGTC_1118 chelidonine 4.45 707.5 nM 2.44E-6 11 4.38E-6
10 SGTC_3157 9099274 4.25 49.5 µM 6.20E-6 14 1.06E-5
11 SGTC_2431 5490079 4.19 200.0 µM 8.17E-6 26 1.38E-5
12 SGTC_411 enrofloxacin 4.15 100.0 µM 9.80E-6 DNA damage response 10 1.64E-5
13 SGTC_933 2914-0560 3.78 114.0 µM 4.97E-5 28 7.71E-5
14 SGTC_1357 1503-1303 3.77 39.5 µM 5.24E-5 38 8.12E-5
15 SGTC_883 0850-0245 3.76 24.6 µM 5.49E-5 cell wall 36 8.48E-5
16 SGTC_2044 5102272 3.71 200.0 µM 6.70E-5 14 1.03E-4
17 SGTC_1496 4469-0713 3.69 57.4 µM 7.43E-5 28 1.13E-4
18 SGTC_2241 6772625 3.63 37.8 µM 9.37E-5 36 1.41E-4
19 SGTC_2142 5622915 3.63 118.5 µM 9.37E-5 18 1.41E-4
20 SGTC_2362 9071156 3.60 126.0 µM 1.07E-4 14 1.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 5.62E-34 YFR012W DCV1 hom Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
0.171 2.48E-23 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.145 2.90E-17 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.126 2.67E-13 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.102 2.77E-9 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.100 5.63E-9 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.097 1.54E-8 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.093 6.86E-8 YDL124W YDL124W hom NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
0.092 8.76E-8 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.083 1.37E-6 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.081 2.36E-6 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.080 3.97E-6 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.079 4.40E-6 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.079 4.43E-6 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.077 7.37E-6 YNL258C DSL1 het Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene