YCR006C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR006C / YCR006C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.36|P-value:1.16E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.34|P-value:5.96E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.49|P-value:3.61E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:6.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.32|P-value:1.25E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.53|P-value:3.10E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.22|P-value:9.07E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.25|P-value:8.07E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.45|P-value:4.15E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.85|P-value:9.52E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.44|P-value:4.24E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.42|P-value:4.53E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.12|P-value:3.20E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:7.79|P-value:2.06E-14 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.43|P-value:4.39E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.30|P-value:6.88E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.45|P-value:4.03E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.24|P-value:8.49E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.24|P-value:1.81E-7 ID:SGTC_1958|Compound:st076513|FD-Score:-4.97|P-value:7.37E-7 ID:SGTC_1960|Compound:st011366|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.42|P-value:4.54E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.42|P-value:4.63E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.24|P-value:8.48E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.99|P-value:5.40E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.47|P-value:7.31E-6 ID:SGTC_2242|Compound:6630449|FD-Score:7.96|P-value:5.99E-15 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.13|P-value:3.06E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.28|P-value:7.35E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.61|P-value:2.32E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.39|P-value:4.99E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.97|P-value:3.46E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.31|P-value:6.73E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.79|P-value:1.19E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.09|P-value:3.69E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.41|P-value:4.65E-4 ID:SGTC_3041|Compound:9091929|FD-Score:10.80|P-value:5.08E-26 ID:SGTC_3069|Compound:9117009|FD-Score:-9.22|P-value:1.97E-19 ID:SGTC_3071|Compound:9117417|FD-Score:-6.48|P-value:1.64E-10 ID:SGTC_3073|Compound:9114972|FD-Score:-6.24|P-value:7.26E-10 ID:SGTC_3096|Compound:9117468|FD-Score:-3.19|P-value:9.83E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.11|P-value:3.55E-7 ID:SGTC_3329|Compound:9141233|FD-Score:4.08|P-value:3.76E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.36|P-value:1.16E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.34|P-value:5.96E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.49|P-value:3.61E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.30|P-value:6.81E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.32|P-value:1.25E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.53|P-value:3.10E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.22|P-value:9.07E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.34|P-value:5.94E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.25|P-value:8.07E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.45|P-value:4.15E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.85|P-value:9.52E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:3.44|P-value:4.24E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.42|P-value:4.53E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.12|P-value:3.20E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:7.79|P-value:2.06E-14 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.43|P-value:4.39E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.30|P-value:6.88E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.45|P-value:4.03E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.24|P-value:8.49E-4 ID:SGTC_1953|Compound:st076800|FD-Score:5.24|P-value:1.81E-7 ID:SGTC_1958|Compound:st076513|FD-Score:-4.97|P-value:7.37E-7 ID:SGTC_1960|Compound:st011366|FD-Score:3.62|P-value:2.23E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.42|P-value:4.54E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-3.42|P-value:4.63E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.24|P-value:8.48E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.99|P-value:5.40E-5 ID:SGTC_2086|Compound:5274770|FD-Score:4.31|P-value:1.44E-5 ID:SGTC_2165|Compound:5727197|FD-Score:4.47|P-value:7.31E-6 ID:SGTC_2242|Compound:6630449|FD-Score:7.96|P-value:5.99E-15 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.13|P-value:3.06E-5 ID:SGTC_2390|Compound:9097792|FD-Score:3.35|P-value:5.82E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.28|P-value:7.35E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.61|P-value:2.32E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.39|P-value:4.99E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.97|P-value:3.46E-9 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.31|P-value:6.73E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.79|P-value:1.19E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.09|P-value:3.69E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.41|P-value:4.65E-4 ID:SGTC_3041|Compound:9091929|FD-Score:10.80|P-value:5.08E-26 ID:SGTC_3069|Compound:9117009|FD-Score:-9.22|P-value:1.97E-19 ID:SGTC_3071|Compound:9117417|FD-Score:-6.48|P-value:1.64E-10 ID:SGTC_3073|Compound:9114972|FD-Score:-6.24|P-value:7.26E-10 ID:SGTC_3096|Compound:9117468|FD-Score:-3.19|P-value:9.83E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.11|P-value:3.55E-7 ID:SGTC_3329|Compound:9141233|FD-Score:4.08|P-value:3.76E-5

Top fitness defect scores for YCR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3041 9091929 10.80 49.5 µM 5.08E-26 redox potentiating 1 1.54E-27
2 SGTC_2242 6630449 7.96 61.3 µM 5.99E-15 Golgi 10 8.92E-16
3 SGTC_1077 5-fluorocytosine 7.79 377.0 nM 2.06E-14 exosome 1 3.31E-15
4 SGTC_2604 4'-hydroxychalcone 5.97 11.3 µM 3.46E-9 7 1.17E-9
5 SGTC_165 k038-0023 5.32 64.4 µM 1.25E-7 ubiquinone biosynthesis & proteasome 36 5.25E-8
6 SGTC_1953 st076800 5.24 12.1 µM 1.81E-7 20 7.82E-8
7 SGTC_3211 9128781 5.11 49.5 µM 3.55E-7 34 1.59E-7
8 SGTC_2165 5727197 4.47 32.1 µM 7.31E-6 27 3.95E-6
9 SGTC_6 0844-0013 4.36 19.8 µM 1.16E-5 58 6.46E-6
10 SGTC_2086 5274770 4.31 176.6 µM 1.44E-5 15 8.10E-6
11 SGTC_2251 lansoprazole 4.13 556.0 µM 3.06E-5 19 1.80E-5
12 SGTC_1048 3161-0300 4.12 24.5 µM 3.20E-5 18 1.89E-5
13 SGTC_2623 humulene 4.09 100.0 µM 3.69E-5 15 2.20E-5
14 SGTC_3329 9141233 4.08 27.6 µM 3.76E-5 13 2.24E-5
15 SGTC_2012 4023501 3.99 200.0 µM 5.40E-5 28 3.28E-5
16 SGTC_764 1951-2361 3.85 146.0 µM 9.52E-5 41 5.99E-5
17 SGTC_3148 9097893 3.79 49.5 µM 1.17E-4 40 7.46E-5
18 SGTC_2617 dihydrotanshinone i 3.79 20.8 µM 1.19E-4 copper-dependent oxidative stress 51 7.61E-5
19 SGTC_3208 9114115 3.73 49.5 µM 1.46E-4 45 9.43E-5
20 SGTC_1960 st011366 3.62 51.8 µM 2.23E-4 17 1.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 8.55E-24 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.144 5.27E-17 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.119 4.57E-12 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.116 1.90E-11 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.111 1.29E-10 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.106 8.52E-10 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.102 3.39E-9 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.095 3.57E-8 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.092 9.32E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.092 9.43E-8 YLR294C_d YLR294C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
0.091 1.14E-7 YBR010W HHT1 hom Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation
0.088 3.34E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.087 3.90E-7 YOR018W ROD1 hom Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
0.086 5.22E-7 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.085 8.77E-7 YLR269C_d YLR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data