YCR007C_p

Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR007C / YCR007C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.63|P-value:3.48E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.32|P-value:9.55E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.73|P-value:4.82E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.62|P-value:3.56E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.25|P-value:3.54E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.41|P-value:1.87E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:3.83E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.32|P-value:9.68E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.15|P-value:5.22E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:6.87|P-value:6.51E-11 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.48|P-value:5.74E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.80|P-value:1.92E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.22|P-value:3.94E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.54|P-value:4.61E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.38|P-value:7.87E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-4.78|P-value:3.94E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-3.67|P-value:3.06E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.92|P-value:1.55E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.75|P-value:2.30E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.51|P-value:5.18E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.51|P-value:1.22E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.44|P-value:1.68E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.22|P-value:3.99E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-4.04|P-value:7.84E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.38|P-value:7.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.54|P-value:4.60E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.76|P-value:3.66E-8 ID:SGTC_2416|Compound:tofa|FD-Score:4.32|P-value:2.72E-5 ID:SGTC_2449|Compound:5812982|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.80|P-value:3.55E-6 ID:SGTC_2477|Compound:5967686|FD-Score:4.03|P-value:8.11E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-9.25|P-value:2.63E-18 ID:SGTC_2482|Compound:5981709|FD-Score:5.90|P-value:1.78E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.50|P-value:5.42E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.66|P-value:3.09E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:9.61E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.88|P-value:1.44E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.48|P-value:5.69E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.33|P-value:9.13E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.54|P-value:1.09E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-8.30|P-value:4.22E-15 ID:SGTC_2878|Compound:9043973|FD-Score:-8.34|P-value:3.20E-15 ID:SGTC_3298|Compound:9116858|FD-Score:3.56|P-value:4.34E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.77|P-value:4.18E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.61|P-value:3.67E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.63|P-value:3.48E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.32|P-value:9.55E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.73|P-value:4.82E-6 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.62|P-value:3.56E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.25|P-value:3.54E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:4.41|P-value:1.87E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.60|P-value:3.83E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.70|P-value:2.68E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.32|P-value:9.68E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-4.15|P-value:5.22E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:6.87|P-value:6.51E-11 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.57|P-value:4.24E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.48|P-value:5.74E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.80|P-value:1.92E-4 ID:SGTC_1714|Compound:st033236|FD-Score:-4.22|P-value:3.94E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.54|P-value:4.61E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.38|P-value:7.87E-4 ID:SGTC_1761|Compound:st044296|FD-Score:-4.78|P-value:3.94E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-3.67|P-value:3.06E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.92|P-value:1.55E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.75|P-value:2.30E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.51|P-value:5.18E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.51|P-value:1.22E-5 ID:SGTC_2008|Compound:4012253|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.44|P-value:1.68E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.22|P-value:3.99E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-4.04|P-value:7.84E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.38|P-value:7.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.54|P-value:4.60E-4 ID:SGTC_2321|Compound:7390090|FD-Score:5.76|P-value:3.66E-8 ID:SGTC_2416|Compound:tofa|FD-Score:4.32|P-value:2.72E-5 ID:SGTC_2449|Compound:5812982|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-4.80|P-value:3.55E-6 ID:SGTC_2477|Compound:5967686|FD-Score:4.03|P-value:8.11E-5 ID:SGTC_2479|Compound:5617353|FD-Score:-9.25|P-value:2.63E-18 ID:SGTC_2482|Compound:5981709|FD-Score:5.90|P-value:1.78E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.50|P-value:5.42E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.66|P-value:3.09E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.32|P-value:9.61E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.88|P-value:1.44E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.48|P-value:5.69E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.38|P-value:2.13E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.33|P-value:9.13E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-4.54|P-value:1.09E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-8.30|P-value:4.22E-15 ID:SGTC_2878|Compound:9043973|FD-Score:-8.34|P-value:3.20E-15 ID:SGTC_3298|Compound:9116858|FD-Score:3.56|P-value:4.34E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.77|P-value:4.18E-6

Top fitness defect scores for YCR007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1329 1447-1697 6.87 50.6 µM 6.51E-11 1 3.13E-12
2 SGTC_1789 tunicamycin 5.92 25.0 nM 1.55E-8 unfolded protein response 19 1.60E-9
3 SGTC_2482 5981709 5.90 142.7 µM 1.78E-8 PDR1 12 1.87E-9
4 SGTC_2321 7390090 5.76 138.8 µM 3.66E-8 8 4.28E-9
5 SGTC_3351 9150312 4.77 21.6 µM 4.18E-6 cell wall 21 9.41E-7
6 SGTC_497 capsazepine 4.73 133.0 µM 4.82E-6 4 1.11E-6
7 SGTC_2052 5265182 4.44 7.1 µM 1.68E-5 16 4.58E-6
8 SGTC_604 1000-0114 4.41 314.0 µM 1.87E-5 11 5.18E-6
9 SGTC_2818 7996756 4.38 13.0 µM 2.13E-5 13 6.02E-6
10 SGTC_2416 tofa 4.32 880.0 nM 2.72E-5 sphingolipid biosynthesis & PDR1 40 7.92E-6
11 SGTC_602 3130-1533 4.25 38.1 µM 3.54E-5 13 1.07E-5
12 SGTC_2053 5265679 4.22 138.0 µM 3.99E-5 19 1.23E-5
13 SGTC_2477 5967686 4.03 25.2 µM 8.11E-5 24 2.74E-5
14 SGTC_2008 4012253 3.92 172.0 µM 1.22E-4 27 4.37E-5
15 SGTC_2785 7756463 3.88 72.7 µM 1.44E-4 31 5.29E-5
16 SGTC_1701 st028638 3.80 40.4 µM 1.92E-4 18 7.28E-5
17 SGTC_1259 0671-0132 3.69 43.0 µM 2.78E-4 31 1.11E-4
18 SGTC_3332 9141069 3.69 11.2 µM 2.78E-4 23 1.11E-4
19 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.66 100.0 µM 3.09E-4 39 1.25E-4
20 SGTC_271 rotenone 3.63 740.0 µM 3.48E-4 39 1.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.40E-33 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.204 1.27E-32 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.171 2.68E-23 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.168 2.15E-22 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.158 5.58E-20 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.154 4.31E-19 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.152 8.31E-19 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.147 1.18E-17 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.143 1.40E-16 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.138 1.37E-15 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.137 2.27E-15 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.123 1.21E-12 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.119 6.22E-12 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.110 1.90E-10 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.105 1.30E-9 YDR384C ATO3 hom Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters