YCR008W / SAT4

Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR008W / SAT4

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.19|P-value:2.10E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.77|P-value:1.51E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.10|P-value:3.03E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.18|P-value:9.23E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.02|P-value:2.19E-9 ID:SGTC_121|Compound:0557-0495|FD-Score:10.00|P-value:8.98E-23 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:3.03E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.41|P-value:4.14E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.84|P-value:1.16E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:3.16|P-value:9.73E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.03|P-value:4.13E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:4.61|P-value:3.42E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.43|P-value:7.45E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.12|P-value:2.79E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.94|P-value:3.52E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.24|P-value:7.39E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:8.93|P-value:1.89E-18 ID:SGTC_528|Compound:3492-0019|FD-Score:6.46|P-value:1.60E-10 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.77|P-value:1.52E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.97|P-value:5.14E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.25|P-value:1.66E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.56|P-value:2.49E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:7.56E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:4.90|P-value:8.80E-7 ID:SGTC_817|Compound:1391-0715|FD-Score:3.91|P-value:6.54E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:6.54|P-value:9.15E-11 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.48|P-value:5.98E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.32|P-value:7.45E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.55|P-value:3.44E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.25|P-value:1.62E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:6.73|P-value:2.87E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.68|P-value:1.58E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.17|P-value:9.54E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.49|P-value:5.65E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.39|P-value:8.95E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.98|P-value:4.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.06|P-value:6.11E-19 ID:SGTC_1720|Compound:st037298|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.27|P-value:1.52E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.38|P-value:4.57E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.52|P-value:3.75E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.89|P-value:9.68E-5 ID:SGTC_2054|Compound:5233173|FD-Score:7.29|P-value:6.50E-13 ID:SGTC_2140|Compound:5586273|FD-Score:4.52|P-value:5.03E-6 ID:SGTC_2243|Compound:6634756|FD-Score:13.00|P-value:1.37E-36 ID:SGTC_2245|Compound:6637752|FD-Score:8.92|P-value:2.02E-18 ID:SGTC_2342|Compound:7990637|FD-Score:5.25|P-value:1.50E-7 ID:SGTC_2393|Compound:9031399|FD-Score:4.35|P-value:1.08E-5 ID:SGTC_2400|Compound:5203494|FD-Score:4.17|P-value:2.30E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.26|P-value:7.04E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.61|P-value:4.97E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.10|P-value:3.07E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.22|P-value:6.52E-16 ID:SGTC_2802|Compound:7925815|FD-Score:4.46|P-value:6.63E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.27|P-value:6.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.39|P-value:5.98E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.50|P-value:5.50E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.39|P-value:4.41E-4 ID:SGTC_3194|Compound:9111903|FD-Score:6.80|P-value:1.72E-11 ID:SGTC_3200|Compound:9114385|FD-Score:4.89|P-value:9.23E-7 ID:SGTC_3340|Compound:9146634|FD-Score:3.89|P-value:6.99E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.19|P-value:2.10E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.77|P-value:1.51E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:4.10|P-value:3.03E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.18|P-value:9.23E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.02|P-value:2.19E-9 ID:SGTC_121|Compound:0557-0495|FD-Score:10.00|P-value:8.98E-23 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:3.03E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.41|P-value:4.14E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.84|P-value:1.16E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:3.16|P-value:9.73E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:4.03|P-value:4.13E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:4.61|P-value:3.42E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.43|P-value:7.45E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.12|P-value:2.79E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.94|P-value:3.52E-9 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.24|P-value:7.39E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:8.93|P-value:1.89E-18 ID:SGTC_528|Compound:3492-0019|FD-Score:6.46|P-value:1.60E-10 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.77|P-value:1.52E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.97|P-value:5.14E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:4.25|P-value:1.66E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.56|P-value:2.49E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.01|P-value:7.56E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:4.90|P-value:8.80E-7 ID:SGTC_817|Compound:1391-0715|FD-Score:3.91|P-value:6.54E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:6.54|P-value:9.15E-11 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.29|P-value:6.29E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.48|P-value:5.98E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.32|P-value:7.45E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.46|P-value:3.48E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.55|P-value:3.44E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:4.25|P-value:1.62E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:6.73|P-value:2.87E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.68|P-value:1.58E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.35|P-value:5.09E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.17|P-value:9.54E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.49|P-value:5.65E-6 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.76|P-value:1.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.39|P-value:8.95E-6 ID:SGTC_1665|Compound:st014639|FD-Score:3.98|P-value:4.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.06|P-value:6.11E-19 ID:SGTC_1720|Compound:st037298|FD-Score:3.67|P-value:1.66E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.27|P-value:1.52E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.31|P-value:5.83E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.38|P-value:4.57E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.52|P-value:3.75E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.89|P-value:9.68E-5 ID:SGTC_2054|Compound:5233173|FD-Score:7.29|P-value:6.50E-13 ID:SGTC_2140|Compound:5586273|FD-Score:4.52|P-value:5.03E-6 ID:SGTC_2243|Compound:6634756|FD-Score:13.00|P-value:1.37E-36 ID:SGTC_2245|Compound:6637752|FD-Score:8.92|P-value:2.02E-18 ID:SGTC_2342|Compound:7990637|FD-Score:5.25|P-value:1.50E-7 ID:SGTC_2393|Compound:9031399|FD-Score:4.35|P-value:1.08E-5 ID:SGTC_2400|Compound:5203494|FD-Score:4.17|P-value:2.30E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.26|P-value:7.04E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.53|P-value:2.78E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.61|P-value:4.97E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.10|P-value:3.07E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.22|P-value:6.52E-16 ID:SGTC_2802|Compound:7925815|FD-Score:4.46|P-value:6.63E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.27|P-value:6.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.39|P-value:5.98E-4 ID:SGTC_3066|Compound:9117245|FD-Score:4.50|P-value:5.50E-6 ID:SGTC_3170|Compound:9103054|FD-Score:3.39|P-value:4.41E-4 ID:SGTC_3194|Compound:9111903|FD-Score:6.80|P-value:1.72E-11 ID:SGTC_3200|Compound:9114385|FD-Score:4.89|P-value:9.23E-7 ID:SGTC_3340|Compound:9146634|FD-Score:3.89|P-value:6.99E-5

Top fitness defect scores for YCR008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2243 6634756 13.00 200.0 µM 1.37E-36 1 1.12E-38
2 SGTC_121 0557-0495 10.00 61.3 µM 8.98E-23 calcium & mitochondrial duress 7 5.41E-24
3 SGTC_1712 st032288 9.06 53.4 µM 6.11E-19 calcium & mitochondrial duress 33 6.37E-20
4 SGTC_502 l-744,832 8.93 89.3 µM 1.89E-18 calcium & mitochondrial duress 5 2.11E-19
5 SGTC_2245 6637752 8.92 200.0 µM 2.02E-18 1 2.26E-19
6 SGTC_2737 bleomycin 8.22 30.5 nM 6.52E-16 Golgi 18 1.04E-16
7 SGTC_2054 5233173 7.29 129.0 µM 6.50E-13 mitochondrial response to ROS 10 1.58E-13
8 SGTC_3194 9111903 6.80 49.5 µM 1.72E-11 4 5.07E-12
9 SGTC_1345 1488-0192 6.73 31.4 µM 2.87E-11 2 8.73E-12
10 SGTC_902 1120-0002 6.54 2.1 µM 9.15E-11 azole & statin 17 2.98E-11
11 SGTC_528 3492-0019 6.46 172.0 µM 1.60E-10 calcium & mitochondrial duress 109 5.40E-11
12 SGTC_120 rhodamine 6G 6.02 52.3 µM 2.19E-9 mitochondrial processes 9 8.60E-10
13 SGTC_467 ro 31-8220 5.94 72.8 µM 3.52E-9 calcium & mitochondrial duress 30 1.42E-9
14 SGTC_2342 7990637 5.25 118.9 µM 1.50E-7 RNA processing & uracil transport 9 7.54E-8
15 SGTC_813 k007-0158 4.90 173.0 µM 8.80E-7 fatty acid desaturase (OLE1) 16 4.89E-7
16 SGTC_3200 9114385 4.89 49.5 µM 9.23E-7 17 5.14E-7
17 SGTC_136 0097-0015 4.84 404.5 µM 1.16E-6 60S ribosome export 5 6.53E-7
18 SGTC_314 1671-0008 4.61 2.7 µM 3.42E-6 30 2.05E-6
19 SGTC_2140 5586273 4.52 200.0 µM 5.03E-6 RSC complex & mRNA processing 3 3.08E-6
20 SGTC_3066 9117245 4.50 49.5 µM 5.50E-6 8 3.38E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 2.43E-89 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.305 4.67E-73 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.257 6.36E-52 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.231 1.01E-41 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.218 2.10E-37 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.215 2.55E-36 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.185 2.60E-27 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
0.178 2.94E-25 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.173 7.23E-24 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.171 2.30E-23 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.165 5.96E-22 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.163 1.77E-21 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
0.161 8.25E-21 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.160 9.96E-21 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.157 5.76E-20 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion