YCR009C / RVS161

Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR009C / RVS161

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.56|P-value:4.19E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.69|P-value:2.67E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.31|P-value:9.34E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.67|P-value:2.83E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.53|P-value:4.61E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.97|P-value:9.69E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.79|P-value:3.47E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.93|P-value:1.84E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:2.77E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.86|P-value:1.42E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.68|P-value:2.75E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.35|P-value:8.45E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.18|P-value:4.38E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:4.41|P-value:1.73E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:4.85E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.30|P-value:2.74E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:4.96|P-value:1.63E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.33|P-value:2.43E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.65|P-value:3.03E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.65|P-value:5.74E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.45|P-value:6.01E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.40|P-value:6.96E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.69|P-value:5.28E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.42|P-value:6.60E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.50|P-value:1.19E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.54|P-value:4.41E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.29|P-value:9.92E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.31|P-value:9.70E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.60|P-value:7.92E-6 ID:SGTC_1656|Compound:st012921|FD-Score:4.80|P-value:3.23E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.45|P-value:5.99E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.36|P-value:8.20E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.10|P-value:6.00E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.56|P-value:4.12E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.75|P-value:2.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.08|P-value:6.37E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.63|P-value:3.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.36|P-value:8.01E-4 ID:SGTC_2455|Compound:5377712|FD-Score:7.78|P-value:1.43E-13 ID:SGTC_2479|Compound:5617353|FD-Score:-5.06|P-value:1.02E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.52|P-value:4.71E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.33|P-value:2.82E-7 ID:SGTC_2816|Compound:7982706|FD-Score:6.80|P-value:8.37E-11 ID:SGTC_2960|Compound:9079389|FD-Score:4.05|P-value:7.19E-5 ID:SGTC_2980|Compound:9014342|FD-Score:5.28|P-value:3.65E-7 ID:SGTC_3103|Compound:9120822|FD-Score:5.08|P-value:9.42E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-4.19|P-value:4.35E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.56|P-value:4.19E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.69|P-value:2.67E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.31|P-value:9.34E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.67|P-value:2.83E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.53|P-value:4.61E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.69|P-value:5.31E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.97|P-value:9.69E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.79|P-value:3.47E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.93|P-value:1.84E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.43|P-value:6.41E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:2.77E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.86|P-value:1.42E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.68|P-value:2.75E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.35|P-value:8.45E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.18|P-value:4.38E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:4.41|P-value:1.73E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:4.85E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.30|P-value:2.74E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:4.96|P-value:1.63E-6 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.33|P-value:2.43E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.65|P-value:3.03E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:5.65|P-value:5.74E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.45|P-value:6.01E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.40|P-value:6.96E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:4.69|P-value:5.28E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.42|P-value:6.60E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:4.50|P-value:1.19E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.54|P-value:4.41E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.72|P-value:2.35E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.29|P-value:9.92E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.31|P-value:9.70E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.60|P-value:7.92E-6 ID:SGTC_1656|Compound:st012921|FD-Score:4.80|P-value:3.23E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.45|P-value:5.99E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:-3.36|P-value:8.20E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-4.10|P-value:6.00E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.56|P-value:4.12E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.75|P-value:2.17E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.08|P-value:6.37E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.63|P-value:3.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.36|P-value:8.01E-4 ID:SGTC_2455|Compound:5377712|FD-Score:7.78|P-value:1.43E-13 ID:SGTC_2479|Compound:5617353|FD-Score:-5.06|P-value:1.02E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.52|P-value:4.71E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.88|P-value:1.35E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:5.33|P-value:2.82E-7 ID:SGTC_2816|Compound:7982706|FD-Score:6.80|P-value:8.37E-11 ID:SGTC_2960|Compound:9079389|FD-Score:4.05|P-value:7.19E-5 ID:SGTC_2980|Compound:9014342|FD-Score:5.28|P-value:3.65E-7 ID:SGTC_3103|Compound:9120822|FD-Score:5.08|P-value:9.42E-7 ID:SGTC_3141|Compound:9094609|FD-Score:-4.19|P-value:4.35E-5

Top fitness defect scores for YCR009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2455 5377712 7.78 9.8 µM 1.43E-13 2 3.72E-15
2 SGTC_2816 7982706 6.80 58.4 µM 8.37E-11 azole & statin 11 5.06E-12
3 SGTC_1104 tacrolimus 5.65 29.8 µM 5.74E-8 17 8.19E-9
4 SGTC_275 trichlorophene 5.33 5.7 µM 2.77E-7 mitochondrial stress 148 4.85E-8
5 SGTC_2750 bromebric acid 5.33 70.2 µM 2.82E-7 9 4.95E-8
6 SGTC_2980 9014342 5.28 25.3 µM 3.65E-7 15 6.63E-8
7 SGTC_3103 9120822 5.08 49.5 µM 9.42E-7 4 1.94E-7
8 SGTC_938 3126-1755 4.96 342.0 µM 1.63E-6 6 3.60E-7
9 SGTC_243 5hr heat shock (37°C) + splitomicin 4.93 1.0 µM 1.84E-6 heat shock/prefoldin 25 4.13E-7
10 SGTC_1656 st012921 4.80 11.0 µM 3.23E-6 19 7.80E-7
11 SGTC_241 5hr heat shock (37°C) + cantharidin 4.79 155.4 µM 3.47E-6 cell wall signaling 48 8.44E-7
12 SGTC_1194 1488-0194 4.69 225.0 µM 5.28E-6 16 1.36E-6
13 SGTC_210 3551-0445 4.69 56.8 µM 5.31E-6 46 1.37E-6
14 SGTC_1652 st011932 4.60 78.0 µM 7.92E-6 RSC complex & mRNA processing 6 2.15E-6
15 SGTC_1320 1313-0481 4.50 95.3 µM 1.19E-5 14 3.40E-6
16 SGTC_884 0851-0618 4.41 334.0 µM 1.73E-5 9 5.20E-6
17 SGTC_1013 4112-3890 4.33 241.0 µM 2.43E-5 TSC3-RPN4 23 7.60E-6
18 SGTC_919 tnp00227 4.30 403.6 nM 2.74E-5 RNA pol III & RNase P/MRP 23 8.71E-6
19 SGTC_841 0251-0215 4.18 91.2 µM 4.38E-5 68 1.48E-5
20 SGTC_2136 5328288 4.08 199.3 µM 6.37E-5 18 2.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 3.43E-27 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.165 7.74E-22 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.130 4.71E-14 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.129 9.42E-14 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.119 5.29E-12 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.119 5.36E-12 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.116 1.68E-11 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.110 1.97E-10 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.105 1.24E-9 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.101 5.58E-9 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.100 6.23E-9 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.098 1.19E-8 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.095 3.10E-8 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.094 4.52E-8 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.093 6.66E-8 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay