YCR010C / ADY2

Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR010C / ADY2

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:4.06|P-value:7.82E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.48|P-value:6.14E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.33|P-value:9.40E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.40|P-value:2.09E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.14|P-value:8.63E-7 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.63|P-value:3.56E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.69|P-value:2.87E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.38|P-value:2.31E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.24|P-value:4.06E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.52|P-value:5.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.21|P-value:4.40E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.46|P-value:6.42E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.80|P-value:1.98E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.96|P-value:1.13E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.41|P-value:7.62E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.81|P-value:1.94E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.63|P-value:3.61E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.38|P-value:8.25E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.33|P-value:2.72E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-8.53|P-value:9.72E-16 ID:SGTC_1949|Compound:st076024|FD-Score:5.52|P-value:1.43E-7 ID:SGTC_1983|Compound:st071813|FD-Score:4.11|P-value:6.57E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.38|P-value:8.22E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.36|P-value:8.71E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.24|P-value:3.92E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.26|P-value:3.65E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.85|P-value:3.18E-6 ID:SGTC_2293|Compound:7624732|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.64|P-value:3.41E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.65|P-value:7.44E-6 ID:SGTC_2383|Compound:9036125|FD-Score:4.07|P-value:7.58E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-4.64|P-value:7.67E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-4.01|P-value:9.40E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.55|P-value:4.87E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.67|P-value:3.26E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-5.05|P-value:1.29E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-4.63|P-value:7.82E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.83|P-value:1.81E-4 ID:SGTC_3196|Compound:9111891|FD-Score:6.03|P-value:9.80E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.49|P-value:5.68E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.07|P-value:7.62E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.14|P-value:5.78E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.06|P-value:7.82E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.48|P-value:6.14E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.33|P-value:9.40E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.64|P-value:3.53E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.40|P-value:2.09E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.14|P-value:8.63E-7 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.63|P-value:3.56E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.69|P-value:2.87E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.38|P-value:2.31E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.92|P-value:1.35E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.24|P-value:4.06E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.52|P-value:5.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.03|P-value:1.46E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.21|P-value:4.40E-5 ID:SGTC_1617|Compound:st002906|FD-Score:3.46|P-value:6.42E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.80|P-value:1.98E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.96|P-value:1.13E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.41|P-value:7.62E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.81|P-value:1.94E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.63|P-value:3.61E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.38|P-value:8.25E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.33|P-value:2.72E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-8.53|P-value:9.72E-16 ID:SGTC_1949|Compound:st076024|FD-Score:5.52|P-value:1.43E-7 ID:SGTC_1983|Compound:st071813|FD-Score:4.11|P-value:6.57E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.95|P-value:1.18E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.38|P-value:8.22E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.36|P-value:8.71E-4 ID:SGTC_2075|Compound:5212009|FD-Score:-4.24|P-value:3.92E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.26|P-value:3.65E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.85|P-value:3.18E-6 ID:SGTC_2293|Compound:7624732|FD-Score:3.73|P-value:2.60E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-3.64|P-value:3.41E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.65|P-value:7.44E-6 ID:SGTC_2383|Compound:9036125|FD-Score:4.07|P-value:7.58E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-4.64|P-value:7.67E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:3.72|P-value:2.70E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-4.01|P-value:9.40E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.55|P-value:4.87E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.67|P-value:3.26E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-5.05|P-value:1.29E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-4.63|P-value:7.82E-6 ID:SGTC_2940|Compound:9060638|FD-Score:3.54|P-value:4.90E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.83|P-value:1.81E-4 ID:SGTC_3196|Compound:9111891|FD-Score:6.03|P-value:9.80E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.49|P-value:5.68E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.07|P-value:7.62E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.14|P-value:5.78E-5

Top fitness defect scores for YCR010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3196 9111891 6.03 49.5 µM 9.80E-9 mitochondrial processes 2 7.96E-10
2 SGTC_1949 st076024 5.52 69.1 µM 1.43E-7 6 1.74E-8
3 SGTC_1015 4130-4525 5.14 82.0 µM 8.63E-7 60S ribosome export 7 1.37E-7
4 SGTC_1511 0906-3109 5.03 28.5 µM 1.46E-6 excess fatty acid 21 2.49E-7
5 SGTC_2260 7964312 4.85 200.0 µM 3.18E-6 5 6.12E-7
6 SGTC_2377 9073351 4.65 62.6 µM 7.44E-6 ergosterol biosynthesis 17 1.62E-6
7 SGTC_953 1188-0045 4.40 9.7 µM 2.09E-5 60S ribosome export 20 5.31E-6
8 SGTC_1419 3993-2473 4.38 62.6 µM 2.31E-5 10 5.97E-6
9 SGTC_2251 lansoprazole 4.26 556.0 µM 3.65E-5 15 1.00E-5
10 SGTC_1466 k213-0079 4.24 57.5 µM 4.06E-5 9 1.14E-5
11 SGTC_3356 9151811 4.14 4.5 µM 5.78E-5 cell wall 18 1.70E-5
12 SGTC_1983 st071813 4.11 46.9 µM 6.57E-5 RPP1 & pyrimidine depletion 14 1.98E-5
13 SGTC_2383 9036125 4.07 200.0 µM 7.58E-5 6 2.33E-5
14 SGTC_3346 9158254 4.07 43.6 µM 7.62E-5 11 2.34E-5
15 SGTC_69 0096-0274 4.06 206.7 µM 7.82E-5 mitochondrial processes 37 2.41E-5
16 SGTC_1755 st041960 3.96 45.2 µM 1.13E-4 23 3.69E-5
17 SGTC_2049 5262831 3.95 67.2 µM 1.18E-4 26 3.87E-5
18 SGTC_1442 4112-3290 3.92 3.0 µM 1.35E-4 13 4.50E-5
19 SGTC_2963 9082507 3.83 9.0 µM 1.81E-4 29 6.31E-5
20 SGTC_1846 st056244 3.81 14.8 µM 1.94E-4 32 6.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.04E-11 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.42E-7 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.085 8.64E-7 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.081 2.54E-6 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.079 4.95E-6 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.074 1.99E-5 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.073 2.23E-5 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.070 4.66E-5 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.070 4.81E-5 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.070 5.28E-5 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.068 8.54E-5 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.068 8.87E-5 YNR064C YNR064C hom Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
0.067 1.00E-4 YJR010C-A SPC1 hom Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
0.066 1.19E-4 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene
0.065 1.48E-4 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p