YCR011C / ADP1

Putative ATP-dependent permease of the ABC transporter family of proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR011C / ADP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.96|P-value:7.23E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:4.90E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.63|P-value:5.75E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.83|P-value:2.37E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:5.66|P-value:1.02E-9 ID:SGTC_983|Compound:1491-0821|FD-Score:5.30|P-value:9.59E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.96|P-value:7.31E-8 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.48|P-value:1.00E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:-2.99|P-value:8.84E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:5.86E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.52|P-value:9.30E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.13|P-value:5.99E-6 ID:SGTC_2078|Compound:5212016|FD-Score:-3.17|P-value:4.51E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.17|P-value:4.54E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.70|P-value:5.32E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.69|P-value:4.47E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.36|P-value:2.21E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.82|P-value:1.63E-7 ID:SGTC_2452|Compound:5863136|FD-Score:4.17|P-value:4.82E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.08|P-value:7.68E-6 ID:SGTC_2694|Compound:st077685|FD-Score:2.97|P-value:7.88E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.74|P-value:3.60E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.82|P-value:3.08E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.95|P-value:1.39E-5 ID:SGTC_2893|Compound:9048488|FD-Score:4.68|P-value:3.41E-7 ID:SGTC_2952|Compound:9073731|FD-Score:4.22|P-value:3.86E-6 ID:SGTC_3041|Compound:9091929|FD-Score:6.35|P-value:9.16E-12 ID:SGTC_3116|Compound:9124943|FD-Score:3.21|P-value:3.26E-4 ID:SGTC_3224|Compound:9130643|FD-Score:2.99|P-value:7.33E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.96|P-value:7.23E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:4.90E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.63|P-value:5.75E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.83|P-value:2.37E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.45|P-value:1.26E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:5.66|P-value:1.02E-9 ID:SGTC_983|Compound:1491-0821|FD-Score:5.30|P-value:9.59E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.96|P-value:7.31E-8 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.48|P-value:1.00E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:-2.99|P-value:8.84E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:5.86E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.52|P-value:9.30E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.13|P-value:5.99E-6 ID:SGTC_2078|Compound:5212016|FD-Score:-3.17|P-value:4.51E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.17|P-value:4.54E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.70|P-value:5.32E-5 ID:SGTC_2312|Compound:7706453|FD-Score:3.69|P-value:4.47E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.36|P-value:2.21E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.82|P-value:1.63E-7 ID:SGTC_2452|Compound:5863136|FD-Score:4.17|P-value:4.82E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.36|P-value:1.80E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.08|P-value:7.68E-6 ID:SGTC_2694|Compound:st077685|FD-Score:2.97|P-value:7.88E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.74|P-value:3.60E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.82|P-value:3.08E-5 ID:SGTC_2892|Compound:9047358|FD-Score:3.95|P-value:1.39E-5 ID:SGTC_2893|Compound:9048488|FD-Score:4.68|P-value:3.41E-7 ID:SGTC_2952|Compound:9073731|FD-Score:4.22|P-value:3.86E-6 ID:SGTC_3041|Compound:9091929|FD-Score:6.35|P-value:9.16E-12 ID:SGTC_3116|Compound:9124943|FD-Score:3.21|P-value:3.26E-4 ID:SGTC_3224|Compound:9130643|FD-Score:2.99|P-value:7.33E-4

Top fitness defect scores for YCR011C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3041 9091929 6.35 49.5 µM 9.16E-12 redox potentiating 4 1.10E-10
2 SGTC_982 1491-0518 5.66 27.5 µM 1.02E-9 2 7.55E-9
3 SGTC_983 1491-0821 5.30 12.2 µM 9.59E-9 3 5.67E-8
4 SGTC_58 0957-0393 4.96 9.0 µM 7.23E-8 cell wall 287 3.48E-7
5 SGTC_1273 0849-0096 4.96 14.1 µM 7.31E-8 RPP1 & pyrimidine depletion 6 3.52E-7
6 SGTC_2440 5628896 4.82 157.8 µM 1.63E-7 12 7.22E-7
7 SGTC_2893 9048488 4.68 26.0 µM 3.41E-7 fatty acid desaturase (OLE1) 13 1.40E-6
8 SGTC_1449 4112-4002 4.48 201.0 µM 1.00E-6 RPP1 & pyrimidine depletion 14 3.68E-6
9 SGTC_2952 9073731 4.22 13.8 µM 3.86E-6 tubulin folding & SWR complex 35 1.24E-5
10 SGTC_2452 5863136 4.17 48.4 µM 4.82E-6 19 1.51E-5
11 SGTC_2065 5221596 4.13 34.3 µM 5.99E-6 12 1.84E-5
12 SGTC_2683 piperine 4.08 63.0 µM 7.68E-6 15 2.30E-5
13 SGTC_2892 9047358 3.95 58.4 µM 1.39E-5 9 3.91E-5
14 SGTC_798 1287-0182 3.83 476.0 µM 2.37E-5 26 6.34E-5
15 SGTC_2725 haloperidol 3.74 53.2 µM 3.60E-5 plasma membrane duress 42 9.22E-5
16 SGTC_2312 7706453 3.69 155.7 µM 4.47E-5 32 1.12E-4
17 SGTC_785 1270-0111 3.63 65.3 µM 5.75E-5 40 1.40E-4
18 SGTC_1512 0259-0544 3.63 12.2 µM 5.86E-5 26 1.43E-4
19 SGTC_1953 st076800 3.52 12.1 µM 9.30E-5 61 2.16E-4
20 SGTC_977 1348-1378 3.45 135.0 µM 1.26E-4 35 2.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 5.04E-23 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.154 2.93E-19 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.153 6.16E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.143 1.05E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.134 7.96E-15 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.131 2.91E-14 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 6.93E-14 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.128 1.20E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.125 4.40E-13 YDR504C SPG3 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.117 9.23E-12 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.116 1.46E-11 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.116 1.90E-11 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.115 2.91E-11 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.110 1.64E-10 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.109 2.31E-10 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm