YCR015C_p

Putative protein of unknown function; YCR015C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR015C / YCR015C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-6.04|P-value:3.97E-11 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.30|P-value:1.91E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.06|P-value:5.29E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.02|P-value:6.15E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.03|P-value:5.51E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.87|P-value:1.52E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.51|P-value:8.58E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.49|P-value:9.29E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.77|P-value:1.64E-13 ID:SGTC_943|Compound:3253-1379|FD-Score:3.76|P-value:2.81E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.03|P-value:7.67E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.48|P-value:9.69E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.04|P-value:5.23E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.26|P-value:2.19E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.23|P-value:2.50E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.16|P-value:3.31E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.51|P-value:6.73E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.09|P-value:4.30E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.78|P-value:2.53E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.70|P-value:3.59E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.35|P-value:1.54E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.15|P-value:3.69E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.11|P-value:5.14E-6 ID:SGTC_2015|Compound:5119600|FD-Score:3.54|P-value:7.54E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.40|P-value:1.35E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.10|P-value:4.46E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.80|P-value:2.16E-5 ID:SGTC_2288|Compound:7946289|FD-Score:6.69|P-value:3.58E-13 ID:SGTC_2291|Compound:7917025|FD-Score:-5.88|P-value:1.28E-10 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.19|P-value:3.17E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.91|P-value:1.15E-10 ID:SGTC_2412|Compound:st077135|FD-Score:3.17|P-value:3.41E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.11|P-value:5.26E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.05|P-value:6.96E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.48|P-value:9.77E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-4.05|P-value:6.51E-6 ID:SGTC_2915|Compound:7971052|FD-Score:3.50|P-value:8.68E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.35|P-value:1.64E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.98|P-value:7.05E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-2.90|P-value:8.80E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.05|P-value:6.39E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:-6.04|P-value:3.97E-11 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.30|P-value:1.91E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.06|P-value:5.29E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.02|P-value:6.15E-4 ID:SGTC_269|Compound:exalamide|FD-Score:-3.03|P-value:5.51E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.87|P-value:1.52E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:3.51|P-value:8.58E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:3.49|P-value:9.29E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.77|P-value:1.64E-13 ID:SGTC_943|Compound:3253-1379|FD-Score:3.76|P-value:2.81E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:3.27|P-value:2.25E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.03|P-value:7.67E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.48|P-value:9.69E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.04|P-value:5.23E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.26|P-value:2.19E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.23|P-value:2.50E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.14|P-value:3.83E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.16|P-value:3.31E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.51|P-value:6.73E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.09|P-value:4.30E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.78|P-value:2.53E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.70|P-value:3.59E-5 ID:SGTC_1979|Compound:st071809|FD-Score:4.35|P-value:1.54E-6 ID:SGTC_1999|Compound:st074831|FD-Score:3.15|P-value:3.69E-4 ID:SGTC_2008|Compound:4012253|FD-Score:4.11|P-value:5.14E-6 ID:SGTC_2015|Compound:5119600|FD-Score:3.54|P-value:7.54E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.40|P-value:1.35E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.22|P-value:2.76E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.10|P-value:4.46E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.97|P-value:7.42E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.80|P-value:2.16E-5 ID:SGTC_2288|Compound:7946289|FD-Score:6.69|P-value:3.58E-13 ID:SGTC_2291|Compound:7917025|FD-Score:-5.88|P-value:1.28E-10 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.19|P-value:3.17E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.91|P-value:1.15E-10 ID:SGTC_2412|Compound:st077135|FD-Score:3.17|P-value:3.41E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.11|P-value:5.26E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.89|P-value:9.77E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.05|P-value:6.96E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.48|P-value:9.77E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-4.05|P-value:6.51E-6 ID:SGTC_2915|Compound:7971052|FD-Score:3.50|P-value:8.68E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.35|P-value:1.64E-4 ID:SGTC_3044|Compound:9093193|FD-Score:2.98|P-value:7.05E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-2.90|P-value:8.80E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-4.05|P-value:6.39E-6

Top fitness defect scores for YCR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2288 7946289 6.69 167.3 µM 3.58E-13 4 1.13E-11
2 SGTC_2407 paclitaxel 5.91 400.0 µM 1.15E-10 9 1.71E-9
3 SGTC_1642 st009582 4.51 77.7 µM 6.73E-7 RPP1 & pyrimidine depletion 8 3.29E-6
4 SGTC_1979 st071809 4.35 45.3 µM 1.54E-6 RPP1 & pyrimidine depletion 6 6.79E-6
5 SGTC_2008 4012253 4.11 172.0 µM 5.14E-6 21 1.94E-5
6 SGTC_2428 5615643 4.11 7.8 µM 5.26E-6 28 1.98E-5
7 SGTC_2697 mebhydrolin 4.05 72.4 µM 6.96E-6 NEO1 62 2.53E-5
8 SGTC_1133 3473-0247 4.03 50.0 µM 7.67E-6 RSC complex & mRNA processing 44 2.75E-5
9 SGTC_1702 st027038 3.78 51.0 µM 2.53E-5 15 7.83E-5
10 SGTC_943 3253-1379 3.76 105.0 µM 2.81E-5 30 8.58E-5
11 SGTC_1836 st055642 3.70 81.0 µM 3.59E-5 21 1.06E-4
12 SGTC_2015 5119600 3.54 184.0 µM 7.54E-5 40 2.03E-4
13 SGTC_274 sirtinol 3.51 40.1 µM 8.58E-5 36 2.27E-4
14 SGTC_2915 7971052 3.50 15.2 µM 8.68E-5 12 2.30E-4
15 SGTC_319 1348-1596 3.49 45.5 µM 9.29E-5 RSC & ERG11 29 2.44E-4
16 SGTC_1250 0485-0349 3.48 40.2 µM 9.69E-5 53 2.53E-4
17 SGTC_2750 bromebric acid 3.48 70.2 µM 9.77E-5 47 2.55E-4
18 SGTC_2022 5136654 3.40 200.0 µM 1.35E-4 38 3.38E-4
19 SGTC_3014 9081533 3.35 49.5 µM 1.64E-4 20 4.00E-4
20 SGTC_1115 galangin 3.34 695.7 nM 1.74E-4 RPP1 & pyrimidine depletion 28 4.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.19E-41 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.217 6.90E-37 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.206 1.38E-33 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.190 1.48E-28 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.186 1.37E-27 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.186 1.59E-27 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.179 1.34E-25 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.171 1.66E-23 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.158 4.08E-20 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.155 1.94E-19 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.151 1.55E-18 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.148 7.42E-18 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.144 3.97E-17 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.139 6.17E-16 YLR013W GAT3 hom Protein containing GATA family zinc finger motifs
0.135 3.91E-15 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins