YCR017C / CWH43

Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR017C / CWH43

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.51|P-value:1.60E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.82|P-value:4.30E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.67|P-value:3.90E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.82|P-value:2.29E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.81|P-value:2.33E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.98|P-value:1.29E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.45|P-value:8.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:7.86|P-value:1.09E-13 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.56|P-value:5.67E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.73|P-value:3.15E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.82|P-value:4.13E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:3.57|P-value:5.40E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.36|P-value:2.79E-15 ID:SGTC_731|Compound:3966-0296|FD-Score:3.83|P-value:2.18E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.20|P-value:5.57E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.75|P-value:4.85E-8 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.39|P-value:9.75E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.49|P-value:7.06E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.71|P-value:3.30E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.33|P-value:3.26E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.72|P-value:6.43E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:5.83|P-value:3.13E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.57|P-value:5.44E-4 ID:SGTC_1615|Compound:st002656|FD-Score:5.64|P-value:8.41E-8 ID:SGTC_1620|Compound:st003704|FD-Score:-3.52|P-value:2.76E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.17|P-value:6.16E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.40|P-value:9.47E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.60|P-value:2.09E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.55|P-value:5.77E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.13|P-value:7.28E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.23|P-value:4.99E-5 ID:SGTC_2025|Compound:5147754|FD-Score:3.92|P-value:1.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.56|P-value:5.57E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.78|P-value:2.65E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.78|P-value:2.64E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.56|P-value:4.65E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-4.11|P-value:3.07E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.92|P-value:2.71E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.50|P-value:6.80E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.55|P-value:2.54E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.42|P-value:8.72E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.94|P-value:1.73E-8 ID:SGTC_2959|Compound:9079155|FD-Score:3.65|P-value:4.07E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.75|P-value:2.96E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.65|P-value:4.16E-4 ID:SGTC_3054|Compound:9094397|FD-Score:5.78|P-value:4.11E-8 ID:SGTC_3222|Compound:9128301|FD-Score:4.47|P-value:1.85E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:4.51|P-value:1.60E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.82|P-value:4.30E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.67|P-value:3.90E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.82|P-value:2.29E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.44|P-value:8.33E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.81|P-value:2.33E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.98|P-value:1.29E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.45|P-value:8.11E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:7.86|P-value:1.09E-13 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.56|P-value:5.67E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.73|P-value:3.15E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:4.82|P-value:4.13E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:3.57|P-value:5.40E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:8.36|P-value:2.79E-15 ID:SGTC_731|Compound:3966-0296|FD-Score:3.83|P-value:2.18E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.20|P-value:5.57E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.75|P-value:4.85E-8 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.39|P-value:9.75E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.49|P-value:7.06E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.71|P-value:3.30E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.33|P-value:3.26E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.76|P-value:2.86E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.72|P-value:6.43E-6 ID:SGTC_1540|Compound:guanosine|FD-Score:5.83|P-value:3.13E-8 ID:SGTC_1608|Compound:st001473|FD-Score:3.57|P-value:5.44E-4 ID:SGTC_1615|Compound:st002656|FD-Score:5.64|P-value:8.41E-8 ID:SGTC_1620|Compound:st003704|FD-Score:-3.52|P-value:2.76E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.17|P-value:6.16E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.49|P-value:1.76E-5 ID:SGTC_1820|Compound:st053765|FD-Score:3.40|P-value:9.47E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.60|P-value:2.09E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.55|P-value:5.77E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.13|P-value:7.28E-5 ID:SGTC_2010|Compound:4012422|FD-Score:4.23|P-value:4.99E-5 ID:SGTC_2025|Compound:5147754|FD-Score:3.92|P-value:1.57E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.68|P-value:3.69E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.56|P-value:5.57E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.78|P-value:2.65E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.78|P-value:2.64E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.56|P-value:4.65E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-4.11|P-value:3.07E-5 ID:SGTC_2702|Compound:st077768|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.92|P-value:2.71E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.50|P-value:6.80E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.55|P-value:2.54E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.42|P-value:8.72E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.94|P-value:1.73E-8 ID:SGTC_2959|Compound:9079155|FD-Score:3.65|P-value:4.07E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.75|P-value:2.96E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.65|P-value:4.16E-4 ID:SGTC_3054|Compound:9094397|FD-Score:5.78|P-value:4.11E-8 ID:SGTC_3222|Compound:9128301|FD-Score:4.47|P-value:1.85E-5

Top fitness defect scores for YCR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 8.36 20.3 µM 2.79E-15 26 3.02E-17
2 SGTC_391 gliotoxin 7.86 8.3 µM 1.09E-13 13 1.88E-15
3 SGTC_2873 9040596 5.94 71.4 µM 1.73E-8 15 1.41E-9
4 SGTC_1540 guanosine 5.83 70.6 µM 3.13E-8 2 2.77E-9
5 SGTC_3054 9094397 5.78 49.5 µM 4.11E-8 fatty acid desaturase (OLE1) 9 3.77E-9
6 SGTC_1194 1488-0194 5.75 225.0 µM 4.85E-8 7 4.55E-9
7 SGTC_1615 st002656 5.64 86.5 µM 8.41E-8 redox potentiating 3 8.48E-9
8 SGTC_2703 st077852 4.92 53.4 µM 2.71E-6 6 4.34E-7
9 SGTC_640 3381-0960 4.82 37.1 µM 4.13E-6 1 7.02E-7
10 SGTC_173 1273-0061 4.82 2.7 µM 4.30E-6 mitochondrial stress 158 7.35E-7
11 SGTC_1533 dihydroergotamine mesylate 4.72 29.4 µM 6.43E-6 DNA intercalators 7 1.16E-6
12 SGTC_15 0266-0086 4.51 27.1 µM 1.60E-5 endomembrane recycling 44 3.26E-6
13 SGTC_1683 st010134 4.49 710.0 nM 1.76E-5 13 3.63E-6
14 SGTC_3222 9128301 4.47 49.5 µM 1.85E-5 60S ribosome export 13 3.84E-6
15 SGTC_1350 1495-0454 4.33 146.0 µM 3.26E-5 17 7.33E-6
16 SGTC_2010 4012422 4.23 159.0 µM 4.99E-5 16 1.19E-5
17 SGTC_840 0245-0196 4.20 390.0 µM 5.57E-5 7 1.35E-5
18 SGTC_1622 st003707 4.17 19.4 µM 6.16E-5 calcium & mitochondrial duress 29 1.51E-5
19 SGTC_1910 st062352 4.13 60.4 µM 7.28E-5 29 1.83E-5
20 SGTC_234 nsc-17383 3.98 10.7 µM 1.29E-4 ERG2 23 3.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.14E-17 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.134 7.03E-15 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.119 5.02E-12 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.108 4.08E-10 YNL120C_d YNL120C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
0.107 5.10E-10 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.104 1.74E-9 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.099 7.74E-9 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.098 1.29E-8 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.098 1.50E-8 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.097 1.75E-8 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.095 3.35E-8 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.093 5.81E-8 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.093 7.63E-8 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.091 1.30E-7 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.088 3.07E-7 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage