YCR019W / MAK32

Protein necessary for structural stability of L-A double-stranded RNA-containing particles

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR019W / MAK32

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:3.11|P-value:7.53E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.09|P-value:7.78E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:5.37|P-value:1.97E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.09|P-value:8.06E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.29|P-value:3.30E-8 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.66|P-value:9.15E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.44|P-value:2.89E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.18|P-value:5.51E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.58|P-value:1.21E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.06|P-value:1.71E-5 ID:SGTC_1805|Compound:st050013|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.83|P-value:4.49E-5 ID:SGTC_2047|Compound:4141938|FD-Score:-3.90|P-value:3.17E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_2157|Compound:5649910|FD-Score:4.81|P-value:4.46E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.35|P-value:3.03E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.01|P-value:1.96E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.03|P-value:9.87E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.15|P-value:6.33E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.29|P-value:5.88E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.21|P-value:5.24E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.72|P-value:7.13E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.82|P-value:4.53E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.79|P-value:4.84E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:3.11|P-value:7.53E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.09|P-value:7.78E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.29|P-value:3.90E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:5.37|P-value:1.97E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:3.46|P-value:2.07E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.56|P-value:1.41E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.09|P-value:8.06E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.29|P-value:3.30E-8 ID:SGTC_1124|Compound:fisetin|FD-Score:3.53|P-value:1.57E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.66|P-value:9.15E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.44|P-value:2.89E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.18|P-value:5.51E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:-3.58|P-value:1.21E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.47|P-value:1.99E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.06|P-value:1.71E-5 ID:SGTC_1805|Compound:st050013|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_1980|Compound:st071811|FD-Score:4.17|P-value:1.04E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.83|P-value:4.49E-5 ID:SGTC_2047|Compound:4141938|FD-Score:-3.90|P-value:3.17E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.54|P-value:1.74E-6 ID:SGTC_2157|Compound:5649910|FD-Score:4.81|P-value:4.46E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-3.35|P-value:3.03E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.01|P-value:1.96E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.03|P-value:9.87E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.44|P-value:2.23E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.15|P-value:6.33E-4 ID:SGTC_2870|Compound:9038528|FD-Score:4.29|P-value:5.88E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.21|P-value:5.24E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.72|P-value:7.13E-5 ID:SGTC_2957|Compound:9076800|FD-Score:3.15|P-value:6.49E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.82|P-value:4.53E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.79|P-value:4.84E-7

Top fitness defect scores for YCR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_501 nsc-95397 5.37 161.0 µM 1.97E-8 2 3.84E-8
2 SGTC_1119 parthenolide 5.29 318.5 nM 3.30E-8 TSC3-RPN4 16 6.27E-8
3 SGTC_2157 5649910 4.81 96.4 µM 4.46E-7 9 7.60E-7
4 SGTC_3356 9151811 4.79 4.5 µM 4.84E-7 cell wall 11 8.22E-7
5 SGTC_2095 5432005 4.54 200.0 µM 1.74E-6 7 2.80E-6
6 SGTC_1154 4088-0362 4.44 150.0 µM 2.89E-6 11 4.55E-6
7 SGTC_2870 9038528 4.29 13.0 µM 5.88E-6 16 9.00E-6
8 SGTC_1980 st071811 4.17 45.7 µM 1.04E-5 RPP1 & pyrimidine depletion 12 1.55E-5
9 SGTC_1675 st018485 4.06 24.5 µM 1.71E-5 60S ribosome export 25 2.51E-5
10 SGTC_2029 5175081 3.83 200.0 µM 4.49E-5 20 6.31E-5
11 SGTC_2944 9067346 3.72 25.6 µM 7.13E-5 30 9.84E-5
12 SGTC_1126 isoteolin 3.66 1.0 µM 9.15E-5 39 1.25E-4
13 SGTC_1805 st050013 3.64 60.3 µM 1.01E-4 11 1.37E-4
14 SGTC_1013 4112-3890 3.56 241.0 µM 1.41E-4 TSC3-RPN4 48 1.89E-4
15 SGTC_1124 fisetin 3.53 1.2 µM 1.57E-4 50 2.09E-4
16 SGTC_1626 st003712 3.47 1.8 µM 1.99E-4 39 2.64E-4
17 SGTC_722 3534-0461 3.46 190.0 µM 2.07E-4 PDR1 54 2.74E-4
18 SGTC_2578 7,8-dihydroxyflavone 3.44 64.4 µM 2.23E-4 54 2.93E-4
19 SGTC_948 3448-0295 3.44 75.3 µM 2.25E-4 49 2.96E-4
20 SGTC_136 0097-0015 3.29 404.5 µM 3.90E-4 60S ribosome export 44 5.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 2.12E-8 YPL058C PDR12 hom Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
0.092 9.11E-8 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.090 1.83E-7 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
0.089 2.60E-7 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.088 3.22E-7 YKR075C_p YKR075C_p hom Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.084 1.12E-6 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.081 2.74E-6 YJL197W UBP12 hom Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm
0.080 3.50E-6 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.077 7.12E-6 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
0.075 1.22E-5 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.075 1.22E-5 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.074 1.85E-5 YFR041C ERJ5 hom Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
0.074 1.88E-5 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.073 2.16E-5 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.073 2.19E-5 YPL102C_d YPL102C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4