YCR020C / PET18

Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR020C / PET18

Click on Significant Values for Screen Details ID:SGTC_312|Compound:4092-0653|FD-Score:5.09|P-value:2.94E-8 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.55|P-value:5.13E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.97|P-value:6.14E-8 ID:SGTC_417|Compound:st075190|FD-Score:3.56|P-value:8.19E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.95|P-value:5.96E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.25|P-value:1.30E-11 ID:SGTC_554|Compound:4483-2211|FD-Score:3.00|P-value:7.64E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.09|P-value:5.36E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.91|P-value:1.64E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.51|P-value:7.93E-7 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.01|P-value:7.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.27|P-value:1.61E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.49|P-value:6.56E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-2.96|P-value:5.69E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.12|P-value:4.88E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.67|P-value:7.44E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.62|P-value:3.79E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.95|P-value:6.66E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.60|P-value:6.94E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.38|P-value:1.72E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.07|P-value:5.89E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-2.96|P-value:5.68E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.92|P-value:1.36E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.27|P-value:2.67E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.17|P-value:4.05E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.23|P-value:1.97E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-10.20|P-value:1.42E-28 ID:SGTC_2521|Compound:angolensin|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.29|P-value:1.58E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.18|P-value:3.86E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.73|P-value:3.90E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.13|P-value:3.04E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:8.24E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.99|P-value:7.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.27|P-value:2.67E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.01|P-value:4.81E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.61|P-value:3.97E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.21|P-value:1.46E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:5.09|P-value:2.94E-8 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.55|P-value:5.13E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:4.97|P-value:6.14E-8 ID:SGTC_417|Compound:st075190|FD-Score:3.56|P-value:8.19E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.95|P-value:5.96E-4 ID:SGTC_500|Compound:h-89|FD-Score:6.25|P-value:1.30E-11 ID:SGTC_554|Compound:4483-2211|FD-Score:3.00|P-value:7.64E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.09|P-value:5.36E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.91|P-value:1.64E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:4.51|P-value:7.93E-7 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.01|P-value:7.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.27|P-value:1.61E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.49|P-value:6.56E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:-2.96|P-value:5.69E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.12|P-value:4.88E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:5.67|P-value:7.44E-10 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.62|P-value:3.79E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.95|P-value:5.92E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.95|P-value:6.66E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.60|P-value:6.94E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.38|P-value:1.72E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.07|P-value:5.89E-4 ID:SGTC_1792|Compound:st045773|FD-Score:-2.96|P-value:5.68E-4 ID:SGTC_1809|Compound:st050081|FD-Score:5.92|P-value:1.36E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.27|P-value:2.67E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.17|P-value:4.05E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.23|P-value:1.97E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-10.20|P-value:1.42E-28 ID:SGTC_2521|Compound:angolensin|FD-Score:3.42|P-value:1.47E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.29|P-value:1.58E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.18|P-value:3.86E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.48|P-value:1.13E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.73|P-value:3.90E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.13|P-value:3.04E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:8.24E-4 ID:SGTC_2848|Compound:9016370|FD-Score:2.99|P-value:7.79E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.27|P-value:2.67E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_3017|Compound:9080681|FD-Score:-3.01|P-value:4.81E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.61|P-value:3.97E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.21|P-value:1.46E-8

Top fitness defect scores for YCR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_500 h-89 6.25 112.0 µM 1.30E-11 cell wall signaling 9 2.09E-10
2 SGTC_1809 st050081 5.92 57.6 µM 1.36E-10 4 1.61E-9
3 SGTC_1379 2144-0755 5.67 36.5 µM 7.44E-10 6 7.12E-9
4 SGTC_3264 9137442 5.21 49.5 µM 1.46E-8 4 9.60E-8
5 SGTC_312 4092-0653 5.09 6.8 µM 2.94E-8 ergosterol depletion effects on membrane 55 1.77E-7
6 SGTC_367 0335-0881 4.97 7.1 µM 6.14E-8 ubiquinone biosynthesis & proteasome 43 3.38E-7
7 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.95 85.4 µM 6.66E-8 9 3.63E-7
8 SGTC_1040 k898-0338 4.51 155.0 µM 7.93E-7 13 3.18E-6
9 SGTC_762 1165-0429 3.91 115.0 µM 1.64E-5 TSC3-RPN4 18 4.56E-5
10 SGTC_2836 9010338 3.73 19.5 µM 3.90E-5 RPP1 & pyrimidine depletion 35 9.76E-5
11 SGTC_1569 carminic acid 3.60 40.6 µM 6.94E-5 27 1.62E-4
12 SGTC_417 st075190 3.56 100.0 µM 8.19E-5 19 1.88E-4
13 SGTC_2684 capsaicin 3.48 100.0 µM 1.13E-4 28 2.49E-4
14 SGTC_2521 angolensin 3.42 13.4 µM 1.47E-4 20 3.14E-4
15 SGTC_3144 9087057 3.39 49.5 µM 1.64E-4 29 3.47E-4
16 SGTC_1719 st032227 3.38 49.2 µM 1.72E-4 43 3.61E-4
17 SGTC_2930 9013230 3.27 14.9 µM 2.67E-4 heme biosynthesis & mitochondrial translocase 70 5.32E-4
18 SGTC_2034 5197015 3.27 53.1 µM 2.67E-4 SWF1 & branched chain AA biosynthesis 44 5.33E-4
19 SGTC_2621 lithochol-11-enic acid 3.18 100.0 µM 3.86E-4 66 7.39E-4
20 SGTC_2038 4100038 3.17 31.0 µM 4.05E-4 plasma membrane duress 86 7.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.50E-15 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.60E-13 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.09E-12 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.121 1.61E-12 YLR168C UPS2 hom Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI
0.121 2.27E-12 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.119 5.53E-12 YLR214W FRE1 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
0.115 2.94E-11 YJR100C AIM25 hom Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.113 4.70E-11 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.108 4.23E-10 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.107 4.70E-10 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.106 7.66E-10 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.104 1.29E-9 YGR059W SPR3 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
0.104 1.36E-9 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.104 1.71E-9 YDL156W CMR1 hom DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS
0.102 3.71E-9 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p