YCR020W-B / HTL1

Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR020W-B / HTL1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.83|P-value:2.09E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.66|P-value:4.07E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.58|P-value:1.34E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.78|P-value:2.66E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.86|P-value:1.87E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.41|P-value:9.13E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:5.93|P-value:2.72E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.52|P-value:6.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.65|P-value:1.03E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:4.45|P-value:2.28E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.37|P-value:9.32E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-6.61|P-value:5.74E-10 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.08|P-value:1.61E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.22|P-value:8.58E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:7.21E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.57|P-value:1.44E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.49|P-value:7.04E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.55|P-value:1.53E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.59|P-value:5.06E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.86|P-value:1.86E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.37|P-value:9.36E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.06|P-value:8.98E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.42|P-value:8.81E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.58|P-value:1.38E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.52|P-value:6.28E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.87|P-value:2.01E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.96|P-value:1.43E-4 ID:SGTC_2193|Compound:5925765|FD-Score:3.48|P-value:7.34E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.97|P-value:1.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.50|P-value:1.87E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.97|P-value:1.23E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.47|P-value:7.47E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.23|P-value:8.29E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.15|P-value:7.23E-9 ID:SGTC_2544|Compound:sphondin|FD-Score:4.15|P-value:7.34E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-5.75|P-value:5.91E-8 ID:SGTC_2557|Compound:derrustone|FD-Score:4.11|P-value:8.24E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.56|P-value:5.54E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.02|P-value:1.17E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.53|P-value:6.12E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.74|P-value:3.12E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.38|P-value:3.07E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-3.85|P-value:1.89E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.93|P-value:1.61E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.83|P-value:2.09E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.66|P-value:4.07E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.58|P-value:1.34E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.78|P-value:2.66E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.86|P-value:1.87E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.41|P-value:9.13E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:5.93|P-value:2.72E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:3.52|P-value:6.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:4.65|P-value:1.03E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:4.45|P-value:2.28E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.37|P-value:9.32E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-6.61|P-value:5.74E-10 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.08|P-value:1.61E-6 ID:SGTC_1183|Compound:1254-0324|FD-Score:5.22|P-value:8.58E-7 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.48|P-value:7.21E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.57|P-value:1.44E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.49|P-value:7.04E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.55|P-value:1.53E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.59|P-value:5.06E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-3.86|P-value:1.86E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.37|P-value:9.36E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.06|P-value:8.98E-5 ID:SGTC_1719|Compound:st032227|FD-Score:3.41|P-value:9.14E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.42|P-value:8.81E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.58|P-value:1.38E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.52|P-value:6.28E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.87|P-value:2.01E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.96|P-value:1.43E-4 ID:SGTC_2193|Compound:5925765|FD-Score:3.48|P-value:7.34E-4 ID:SGTC_2220|Compound:6782180|FD-Score:3.39|P-value:9.72E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.97|P-value:1.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:4.50|P-value:1.87E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.97|P-value:1.23E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.47|P-value:7.47E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.23|P-value:8.29E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.93|P-value:1.63E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.15|P-value:7.23E-9 ID:SGTC_2544|Compound:sphondin|FD-Score:4.15|P-value:7.34E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-5.75|P-value:5.91E-8 ID:SGTC_2557|Compound:derrustone|FD-Score:4.11|P-value:8.24E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.56|P-value:5.54E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.02|P-value:1.17E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.53|P-value:6.12E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.74|P-value:3.12E-4 ID:SGTC_3032|Compound:9089427|FD-Score:4.38|P-value:3.07E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-3.85|P-value:1.89E-4

Top fitness defect scores for YCR020W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_720 r052-1644 5.93 49.9 µM 2.72E-8 TSC3-RPN4 9 1.51E-9
2 SGTC_2526 patulin 5.23 37.6 µM 8.29E-7 44 8.55E-8
3 SGTC_1183 1254-0324 5.22 198.0 µM 8.58E-7 3 8.90E-8
4 SGTC_1167 k781-0610 5.08 148.0 µM 1.61E-6 RNA processing & uracil transport 8 1.87E-7
5 SGTC_885 0865-0106 4.65 16.8 µM 1.03E-5 TSC3-RPN4 18 1.68E-6
6 SGTC_449 xestospongin c 4.58 11.2 µM 1.34E-5 NEO1-PIK1 43 2.27E-6
7 SGTC_1944 st076371 4.58 56.9 µM 1.38E-5 13 2.37E-6
8 SGTC_1368 1852-0141 4.57 284.0 µM 1.44E-5 ERG2 28 2.47E-6
9 SGTC_1457 k015-0032 4.55 57.3 µM 1.53E-5 24 2.68E-6
10 SGTC_2400 5203494 4.50 178.7 µM 1.87E-5 RSC complex & mRNA processing 16 3.39E-6
11 SGTC_914 3820-6779 4.45 408.0 µM 2.28E-5 12 4.26E-6
12 SGTC_3032 9089427 4.38 49.5 µM 3.07E-5 60S ribosome export 6 6.05E-6
13 SGTC_2544 sphondin 4.15 68.5 µM 7.34E-5 RNA pol III & RNase P/MRP 22 1.69E-5
14 SGTC_2557 derrustone 4.11 83.8 µM 8.24E-5 28 1.94E-5
15 SGTC_2776 terbinafine 4.02 19.9 µM 1.17E-4 cell wall signaling 52 2.93E-5
16 SGTC_2290 7904846 3.97 200.0 µM 1.37E-4 19 3.54E-5
17 SGTC_2189 6047310 3.96 154.4 µM 1.43E-4 RPP1 & pyrimidine depletion 18 3.70E-5
18 SGTC_25 0118-0223 3.93 35.7 µM 1.61E-4 16 4.28E-5
19 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.93 63.6 µM 1.63E-4 42 4.33E-5
20 SGTC_2138 5575593 3.87 77.7 µM 2.01E-4 12 5.55E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 4.36E-8 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.079 4.37E-6 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.077 7.85E-6 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.077 8.55E-6 YDR539W FDC1 hom Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm
0.077 9.24E-6 YBL099W ATP1 hom Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.075 1.52E-5 YMR311C GLC8 hom Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
0.074 1.77E-5 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.073 2.80E-5 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.072 2.88E-5 YKL134C OCT1 hom Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
0.070 4.49E-5 YBL011W SCT1 hom Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
0.069 6.75E-5 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.068 7.36E-5 YLR067C PET309 hom Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
0.068 7.45E-5 YGL172W NUP49 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
0.066 1.50E-4 YMR281W GPI12 het ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
0.065 1.66E-4 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein