YCR023C

Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR023C / YCR023C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.21|P-value:4.48E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.87|P-value:6.46E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.80|P-value:4.32E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.67|P-value:7.32E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.07|P-value:7.46E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.70|P-value:5.80E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.55|P-value:1.26E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.45|P-value:2.06E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.87|P-value:3.17E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.17|P-value:5.29E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.18|P-value:5.11E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.24|P-value:4.09E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.93|P-value:2.41E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.36|P-value:2.54E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.10|P-value:1.12E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.03|P-value:8.65E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.15|P-value:5.57E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.00|P-value:9.60E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.74|P-value:5.50E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.96|P-value:2.14E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.13|P-value:5.98E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.06|P-value:7.62E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.29|P-value:4.60E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:7.64|P-value:1.29E-15 ID:SGTC_1377|Compound:2944-0135|FD-Score:-8.54|P-value:5.08E-19 ID:SGTC_1379|Compound:2144-0755|FD-Score:8.49|P-value:7.81E-19 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.15|P-value:5.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:9.51|P-value:4.01E-23 ID:SGTC_1519|Compound:esterone|FD-Score:-3.00|P-value:9.53E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.03|P-value:8.63E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.00|P-value:1.74E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.38|P-value:2.34E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-7.01|P-value:1.99E-13 ID:SGTC_1743|Compound:st037606|FD-Score:3.10|P-value:6.69E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.23|P-value:6.03E-6 ID:SGTC_1833|Compound:st055984|FD-Score:-3.13|P-value:6.10E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.64|P-value:8.36E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.01|P-value:1.66E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.05|P-value:7.91E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.09|P-value:6.83E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.93|P-value:2.36E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.67|P-value:2.21E-9 ID:SGTC_2549|Compound:cedrol|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.36|P-value:2.50E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.07|P-value:7.48E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.19|P-value:4.77E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.13|P-value:5.96E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.16|P-value:5.47E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.03|P-value:1.54E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.24|P-value:3.99E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.82|P-value:3.86E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-4.72|P-value:5.25E-7 ID:SGTC_3179|Compound:9107801|FD-Score:3.65|P-value:8.09E-5 ID:SGTC_3182|Compound:9108849|FD-Score:-4.06|P-value:1.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.00|P-value:9.42E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.40|P-value:2.21E-4 ID:SGTC_3319|Compound:9138450|FD-Score:6.16|P-value:9.41E-11 ID:SGTC_64|Compound:000l-0018|FD-Score:3.21|P-value:4.48E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.87|P-value:6.46E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.80|P-value:4.32E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.67|P-value:7.32E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.29|P-value:3.28E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.07|P-value:7.46E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:4.70|P-value:5.80E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.55|P-value:1.26E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:4.45|P-value:2.06E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.87|P-value:3.17E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.17|P-value:5.29E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.18|P-value:5.11E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.04|P-value:8.31E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.24|P-value:4.09E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.93|P-value:2.41E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.36|P-value:2.54E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.10|P-value:1.12E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.18|P-value:5.09E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.03|P-value:8.65E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.15|P-value:5.57E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.00|P-value:9.60E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:-3.74|P-value:5.50E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.96|P-value:2.14E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.13|P-value:5.98E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.06|P-value:7.62E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.29|P-value:4.60E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:7.64|P-value:1.29E-15 ID:SGTC_1377|Compound:2944-0135|FD-Score:-8.54|P-value:5.08E-19 ID:SGTC_1379|Compound:2144-0755|FD-Score:8.49|P-value:7.81E-19 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.15|P-value:5.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:9.51|P-value:4.01E-23 ID:SGTC_1519|Compound:esterone|FD-Score:-3.00|P-value:9.53E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.03|P-value:8.63E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.00|P-value:1.74E-5 ID:SGTC_1554|Compound:st069299|FD-Score:-3.38|P-value:2.34E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-7.01|P-value:1.99E-13 ID:SGTC_1743|Compound:st037606|FD-Score:3.10|P-value:6.69E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.23|P-value:6.03E-6 ID:SGTC_1833|Compound:st055984|FD-Score:-3.13|P-value:6.10E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.64|P-value:8.36E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.01|P-value:1.66E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.05|P-value:7.91E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.09|P-value:6.83E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.35|P-value:2.68E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.93|P-value:2.36E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.54|P-value:1.26E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.41|P-value:2.11E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:5.67|P-value:2.21E-9 ID:SGTC_2549|Compound:cedrol|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.36|P-value:2.50E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.40|P-value:2.14E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.07|P-value:7.48E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.19|P-value:4.77E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.13|P-value:5.96E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.16|P-value:5.47E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.03|P-value:1.54E-5 ID:SGTC_3028|Compound:9087778|FD-Score:-3.24|P-value:3.99E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.28|P-value:3.50E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.82|P-value:3.86E-5 ID:SGTC_3171|Compound:9103192|FD-Score:-4.72|P-value:5.25E-7 ID:SGTC_3179|Compound:9107801|FD-Score:3.65|P-value:8.09E-5 ID:SGTC_3182|Compound:9108849|FD-Score:-4.06|P-value:1.32E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.00|P-value:9.42E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.40|P-value:2.21E-4 ID:SGTC_3319|Compound:9138450|FD-Score:6.16|P-value:9.41E-11

Top fitness defect scores for YCR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1514 1189-1591 9.51 158.0 µM 4.01E-23 1 9.96E-22
2 SGTC_1379 2144-0755 8.49 36.5 µM 7.81E-19 1 1.02E-17
3 SGTC_1368 1852-0141 7.64 284.0 µM 1.29E-15 ERG2 3 1.05E-14
4 SGTC_3319 9138450 6.16 16.8 µM 9.41E-11 2 3.69E-10
5 SGTC_165 k038-0023 5.87 64.4 µM 6.46E-10 ubiquinone biosynthesis & proteasome 24 2.24E-9
6 SGTC_2544 sphondin 5.67 68.5 µM 2.21E-9 RNA pol III & RNase P/MRP 9 7.10E-9
7 SGTC_362 0310-0100 4.70 9.0 µM 5.80E-7 RPP1 & pyrimidine depletion 15 1.30E-6
8 SGTC_747 3448-8087 4.45 38.7 µM 2.06E-6 16 4.26E-6
9 SGTC_1359 1582-0056 4.29 520.0 nM 4.60E-6 12 9.06E-6
10 SGTC_1749 st037932 4.23 54.2 µM 6.03E-6 23 1.17E-5
11 SGTC_1115 galangin 4.10 695.7 nM 1.12E-5 RPP1 & pyrimidine depletion 11 2.08E-5
12 SGTC_1886 st057356 4.01 49.9 µM 1.66E-5 60S ribosome export 18 3.01E-5
13 SGTC_1531 st059297 4.00 52.4 µM 1.74E-5 15 3.15E-5
14 SGTC_2212 7123476 3.93 200.0 µM 2.36E-5 4 4.20E-5
15 SGTC_1017 4239-0030 3.93 168.0 µM 2.41E-5 28 4.28E-5
16 SGTC_1601 4'-hydroxyflavanone 3.89 55.5 µM 2.89E-5 RPP1 & pyrimidine depletion 31 5.07E-5
17 SGTC_742 0kpi-0133 3.88 140.0 µM 2.95E-5 ERG2 26 5.17E-5
18 SGTC_749 1000-0129 3.87 128.0 µM 3.17E-5 amide catabolism 21 5.54E-5
19 SGTC_3043 9092303 3.82 49.5 µM 3.86E-5 21 6.66E-5
20 SGTC_3179 9107801 3.65 49.5 µM 8.09E-5 15 1.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.69E-10 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.102 2.91E-9 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.102 3.49E-9 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.100 5.99E-9 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.100 6.14E-9 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.100 6.82E-9 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.096 2.88E-8 YGR266W YGR266W hom Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
0.090 1.54E-7 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.085 7.66E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.085 7.79E-7 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.085 8.94E-7 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.084 1.23E-6 YKR096W ESL2 hom Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain
0.082 2.13E-6 YNL175C NOP13 hom Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
0.079 4.73E-6 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.077 8.93E-6 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated