YCR024C / SLM5

Mitochondrial asparaginyl-tRNA synthetase

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR024C / SLM5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.43|P-value:4.45E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:5.99|P-value:5.87E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:3.33E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.86|P-value:3.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.81|P-value:3.74E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:16.40|P-value:8.91E-48 ID:SGTC_101|Compound:0490-5701|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.53|P-value:2.48E-14 ID:SGTC_118|Compound:0083-0097|FD-Score:5.44|P-value:7.68E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:12.70|P-value:1.33E-29 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.17|P-value:1.13E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.59|P-value:3.80E-7 ID:SGTC_127|Compound:0180-0333|FD-Score:5.08|P-value:3.57E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.80|P-value:2.61E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:8.02|P-value:6.96E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:23.30|P-value:2.23E-94 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.00|P-value:9.20E-31 ID:SGTC_310|Compound:1273-0058|FD-Score:8.28|P-value:1.33E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:6.36|P-value:9.49E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:5.54|P-value:4.80E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:3.82|P-value:3.62E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.47|P-value:3.01E-17 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.80|P-value:1.29E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.90|P-value:2.74E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:4.37|P-value:5.43E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.55|P-value:9.41E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.92|P-value:2.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.91|P-value:8.96E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:3.57|P-value:7.91E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.56|P-value:3.20E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:4.27|P-value:7.82E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:10.70|P-value:1.83E-21 ID:SGTC_963|Compound:1269-2853|FD-Score:3.68|P-value:5.66E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.79|P-value:1.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.53|P-value:3.09E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.58|P-value:3.08E-9 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.30|P-value:1.37E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.02|P-value:1.86E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.60|P-value:9.67E-12 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.20|P-value:1.01E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:5.28|P-value:1.50E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.76|P-value:4.40E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:7.70E-42 ID:SGTC_1655|Compound:st012546|FD-Score:-3.75|P-value:5.15E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.87|P-value:3.46E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.00|P-value:4.78E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.56|P-value:8.03E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.76|P-value:4.90E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.68|P-value:6.35E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.49|P-value:3.61E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:6.41E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.41|P-value:5.41E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.70|P-value:5.26E-4 ID:SGTC_1882|Compound:5615643|FD-Score:7.09|P-value:1.89E-10 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.88|P-value:7.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.50|P-value:9.51E-4 ID:SGTC_2183|Compound:6420625|FD-Score:7.53|P-value:1.48E-11 ID:SGTC_2188|Compound:6126565|FD-Score:-3.83|P-value:3.97E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.91|P-value:2.69E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.96|P-value:2.26E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.50|P-value:5.69E-7 ID:SGTC_2283|Compound:7944793|FD-Score:5.29|P-value:1.43E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-5.23|P-value:2.20E-6 ID:SGTC_2441|Compound:5730946|FD-Score:4.01|P-value:1.93E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.07|P-value:1.59E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.54|P-value:9.58E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.99|P-value:2.38E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.40|P-value:5.75E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.11|P-value:1.55E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.72|P-value:2.13E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-3.98|P-value:2.40E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.39|P-value:5.93E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.55|P-value:8.32E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.54|P-value:8.65E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.05|P-value:1.69E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.25|P-value:9.63E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.70|P-value:5.29E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.58|P-value:2.57E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.43|P-value:5.15E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.38|P-value:6.13E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-3.97|P-value:2.53E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.88|P-value:3.36E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-4.39|P-value:5.93E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.79|P-value:3.97E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.82|P-value:4.10E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.43|P-value:4.45E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:5.99|P-value:5.87E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:3.33E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.86|P-value:3.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.81|P-value:3.74E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:16.40|P-value:8.91E-48 ID:SGTC_101|Compound:0490-5701|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.53|P-value:2.48E-14 ID:SGTC_118|Compound:0083-0097|FD-Score:5.44|P-value:7.68E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:12.70|P-value:1.33E-29 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.17|P-value:1.13E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:5.59|P-value:3.80E-7 ID:SGTC_127|Compound:0180-0333|FD-Score:5.08|P-value:3.57E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.80|P-value:2.61E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:8.02|P-value:6.96E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:23.30|P-value:2.23E-94 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.00|P-value:9.20E-31 ID:SGTC_310|Compound:1273-0058|FD-Score:8.28|P-value:1.33E-13 ID:SGTC_314|Compound:1671-0008|FD-Score:6.36|P-value:9.49E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:5.54|P-value:4.80E-7 ID:SGTC_355|Compound:1311-2252|FD-Score:3.82|P-value:3.62E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:9.47|P-value:3.01E-17 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.80|P-value:1.29E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.90|P-value:2.74E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:4.37|P-value:5.43E-5 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.55|P-value:9.41E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.92|P-value:2.58E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:5.91|P-value:8.96E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:3.57|P-value:7.91E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.56|P-value:3.20E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:4.27|P-value:7.82E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:10.70|P-value:1.83E-21 ID:SGTC_963|Compound:1269-2853|FD-Score:3.68|P-value:5.66E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.79|P-value:1.14E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.53|P-value:3.09E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.58|P-value:3.08E-9 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.30|P-value:1.37E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.02|P-value:1.86E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.60|P-value:9.67E-12 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.20|P-value:1.01E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:5.28|P-value:1.50E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.76|P-value:4.40E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:7.70E-42 ID:SGTC_1655|Compound:st012546|FD-Score:-3.75|P-value:5.15E-4 ID:SGTC_1658|Compound:st012944|FD-Score:-3.87|P-value:3.46E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.00|P-value:4.78E-6 ID:SGTC_1802|Compound:st050112|FD-Score:3.56|P-value:8.03E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.76|P-value:4.90E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.68|P-value:6.35E-4 ID:SGTC_1841|Compound:st054148|FD-Score:4.49|P-value:3.61E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:6.41E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.41|P-value:5.41E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.70|P-value:5.26E-4 ID:SGTC_1882|Compound:5615643|FD-Score:7.09|P-value:1.89E-10 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.88|P-value:7.87E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.50|P-value:9.51E-4 ID:SGTC_2183|Compound:6420625|FD-Score:7.53|P-value:1.48E-11 ID:SGTC_2188|Compound:6126565|FD-Score:-3.83|P-value:3.97E-4 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:3.91|P-value:2.69E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.96|P-value:2.26E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.50|P-value:5.69E-7 ID:SGTC_2283|Compound:7944793|FD-Score:5.29|P-value:1.43E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-5.23|P-value:2.20E-6 ID:SGTC_2441|Compound:5730946|FD-Score:4.01|P-value:1.93E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.07|P-value:1.59E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.54|P-value:9.58E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.99|P-value:2.38E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.40|P-value:5.75E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.11|P-value:1.55E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.72|P-value:2.13E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-3.98|P-value:2.40E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-4.39|P-value:5.93E-5 ID:SGTC_2965|Compound:9082772|FD-Score:3.55|P-value:8.32E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.54|P-value:8.65E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.05|P-value:1.69E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.25|P-value:9.63E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.70|P-value:5.29E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.58|P-value:2.57E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.43|P-value:5.15E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-4.38|P-value:6.13E-5 ID:SGTC_3198|Compound:9112019|FD-Score:-3.97|P-value:2.53E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.88|P-value:3.36E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-4.39|P-value:5.93E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.79|P-value:3.97E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.82|P-value:4.10E-4

Top fitness defect scores for YCR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 23.30 5.3 µM 2.23E-94 38 9.52E-121
2 SGTC_70 0141-0289 16.40 43.3 µM 8.91E-48 mitochondrial stress 7 8.26E-61
3 SGTC_1635 st007035 15.30 42.4 µM 7.70E-42 37 3.53E-53
4 SGTC_275 trichlorophene 13.00 5.7 µM 9.20E-31 mitochondrial stress 16 6.04E-39
5 SGTC_119 0121-0043 12.70 24.8 µM 1.33E-29 mitochondrial stress 4 1.86E-37
6 SGTC_908 3448-7491 10.70 47.7 µM 1.83E-21 mitochondrial stress 6 5.23E-27
7 SGTC_134 0269-0018 9.80 6.9 µM 2.61E-18 40 5.81E-23
8 SGTC_386 1509-0011 9.47 3.1 µM 3.01E-17 50 1.34E-21
9 SGTC_116 0155-0182 8.53 31.8 µM 2.48E-14 mitochondrial response to ROS 8 7.26E-18
10 SGTC_310 1273-0058 8.28 1.1 µM 1.33E-13 mitochondrial stress 80 6.25E-17
11 SGTC_173 1273-0061 8.02 2.7 µM 6.96E-13 mitochondrial stress 65 5.20E-16
12 SGTC_1371 2421-0008 7.60 32.7 µM 9.67E-12 mitochondrial processes 2 1.51E-14
13 SGTC_2183 6420625 7.53 130.5 µM 1.48E-11 mitochondrial processes 8 2.60E-14
14 SGTC_1882 5615643 7.09 20.0 µM 1.89E-10 TRP & mitochondrial translation 12 6.77E-13
15 SGTC_1188 1403-0014 6.58 4.6 µM 3.08E-9 mitochondrial stress 14 2.39E-11
16 SGTC_314 1671-0008 6.36 2.7 µM 9.49E-9 5 1.00E-10
17 SGTC_19 0279-0214 5.99 38.4 µM 5.87E-8 TRP & mitochondrial translation 11 1.03E-9
18 SGTC_782 0083-0095 5.91 30.5 µM 8.96E-8 4 1.76E-9
19 SGTC_2688 kanamycin b 5.72 96.7 µM 2.13E-7 calcium & mitochondrial duress 176 5.33E-9
20 SGTC_124 0136-0217 5.59 7.1 µM 3.80E-7 mitochondrial stress 26 1.11E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.637 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.581 5.33E-302 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.569 8.37E-287 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.566 6.34E-284 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.563 6.48E-280 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.556 2.20E-271 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.546 5.60E-260 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.542 6.14E-256 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.540 1.90E-253 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.533 2.96E-245 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.532 1.08E-244 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.519 2.06E-230 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.516 3.02E-228 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.502 1.54E-213 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.496 1.04E-207 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro