YCR024C-A / PMP1

Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR024C-A / PMP1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.48|P-value:8.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.79|P-value:1.33E-15 ID:SGTC_73|Compound:0327-0325|FD-Score:3.66|P-value:5.04E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.26|P-value:6.57E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.94|P-value:2.00E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.53|P-value:6.41E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.48|P-value:2.65E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.98|P-value:3.78E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:7.31E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.72|P-value:4.13E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.20|P-value:1.45E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.87|P-value:2.51E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.64|P-value:5.43E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.08|P-value:1.22E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.69|P-value:4.59E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.47|P-value:9.13E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.58|P-value:6.47E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.55|P-value:7.17E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.71|P-value:1.17E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.31|P-value:5.27E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.43|P-value:3.45E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.00|P-value:1.65E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.50|P-value:8.31E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.96|P-value:1.87E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.55|P-value:2.17E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.54|P-value:7.41E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.01|P-value:3.36E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.99|P-value:3.56E-8 ID:SGTC_1908|Compound:st060353|FD-Score:5.37|P-value:7.00E-7 ID:SGTC_2050|Compound:5263056|FD-Score:5.47|P-value:4.32E-7 ID:SGTC_2068|Compound:5226020|FD-Score:3.84|P-value:2.76E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.76|P-value:3.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.98|P-value:1.60E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.48|P-value:8.23E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.82|P-value:2.98E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.49|P-value:2.75E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.83|P-value:2.94E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.42|P-value:9.97E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.11|P-value:1.03E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.80|P-value:1.11E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.91|P-value:2.19E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.97|P-value:1.83E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.44|P-value:9.97E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.53|P-value:7.50E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.74|P-value:3.87E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.50|P-value:8.43E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.82|P-value:2.75E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:6.21|P-value:1.20E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:1.60E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.44|P-value:9.89E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.87|P-value:6.08E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.49|P-value:2.76E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.00|P-value:1.52E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.65|P-value:4.87E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.31|P-value:5.33E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.22|P-value:7.52E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.68|P-value:1.18E-5 ID:SGTC_3242|Compound:9133940|FD-Score:4.58|P-value:1.90E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.48|P-value:8.83E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.79|P-value:1.33E-15 ID:SGTC_73|Compound:0327-0325|FD-Score:3.66|P-value:5.04E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.04|P-value:1.41E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.26|P-value:6.57E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.94|P-value:2.00E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.53|P-value:6.41E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.48|P-value:2.65E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.98|P-value:3.78E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:7.31E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.72|P-value:4.13E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.20|P-value:1.45E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.87|P-value:2.51E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.64|P-value:5.43E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.08|P-value:1.22E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.69|P-value:4.59E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.47|P-value:9.13E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.58|P-value:6.47E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.55|P-value:7.17E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.71|P-value:1.17E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.31|P-value:5.27E-5 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.43|P-value:3.45E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.00|P-value:1.65E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.50|P-value:8.31E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.96|P-value:1.87E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.55|P-value:2.17E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.54|P-value:7.41E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.01|P-value:3.36E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.99|P-value:3.56E-8 ID:SGTC_1908|Compound:st060353|FD-Score:5.37|P-value:7.00E-7 ID:SGTC_2050|Compound:5263056|FD-Score:5.47|P-value:4.32E-7 ID:SGTC_2068|Compound:5226020|FD-Score:3.84|P-value:2.76E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.76|P-value:3.67E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.98|P-value:1.60E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.48|P-value:8.23E-4 ID:SGTC_2189|Compound:6047310|FD-Score:3.82|P-value:2.98E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.49|P-value:2.75E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.83|P-value:2.94E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.42|P-value:9.97E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.11|P-value:1.03E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.80|P-value:1.11E-12 ID:SGTC_2442|Compound:5158906|FD-Score:3.91|P-value:2.19E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.97|P-value:1.83E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.44|P-value:9.97E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.53|P-value:7.50E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.74|P-value:3.87E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.50|P-value:8.43E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.82|P-value:2.75E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:6.21|P-value:1.20E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.01|P-value:1.60E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.44|P-value:9.89E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.87|P-value:6.08E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.01|P-value:1.58E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.49|P-value:2.76E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-4.00|P-value:1.52E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.65|P-value:4.87E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.31|P-value:5.33E-5 ID:SGTC_3187|Compound:9109394|FD-Score:4.22|P-value:7.52E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-4.68|P-value:1.18E-5 ID:SGTC_3242|Compound:9133940|FD-Score:4.58|P-value:1.90E-5

Top fitness defect scores for YCR024C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.79 9.0 µM 1.33E-15 cell wall 105 7.72E-19
2 SGTC_2420 aureobasidin a 7.80 50.0 nM 1.11E-12 6 3.01E-15
3 SGTC_451 chloral hydrate 7.53 100.0 µM 6.41E-12 7 2.61E-14
4 SGTC_2549 cedrol 6.21 20.9 µM 1.20E-8 1 2.73E-10
5 SGTC_1803 st050068 5.99 52.4 µM 3.56E-8 NEO1-PIK1 84 1.04E-9
6 SGTC_2050 5263056 5.47 171.0 µM 4.32E-7 fatty acid desaturase (OLE1) 14 2.22E-8
7 SGTC_1908 st060353 5.37 56.5 µM 7.00E-7 RPP1 & pyrimidine depletion 15 4.02E-8
8 SGTC_1000 4048-0884 5.20 8.7 µM 1.45E-6 copper-dependent oxidative stress 13 9.80E-8
9 SGTC_1801 st050089 5.01 28.4 µM 3.36E-6 NEO1-PIK1 73 2.74E-7
10 SGTC_574 1315-0397 4.98 40.0 µM 3.78E-6 12 3.17E-7
11 SGTC_2678 equilin 4.87 100.0 µM 6.08E-6 11 5.67E-7
12 SGTC_1355 1499-0035 4.71 1.7 µM 1.17E-5 3 1.26E-6
13 SGTC_3242 9133940 4.58 49.5 µM 1.90E-5 3 2.30E-6
14 SGTC_1580 hydrocortisone 21-hemisuccinate 4.55 43.2 µM 2.17E-5 9 2.70E-6
15 SGTC_2239 6685329 4.49 187.6 µM 2.75E-5 16 3.60E-6
16 SGTC_2928 9011484 4.49 9.8 µM 2.76E-5 heme biosynthesis & mitochondrial translocase 29 3.62E-6
17 SGTC_1443 4112-3303 4.43 14.0 µM 3.45E-5 4 4.76E-6
18 SGTC_1406 3909-7906 4.31 11.9 µM 5.27E-5 60S ribosome export 5 7.98E-6
19 SGTC_3000 9075062 4.31 71.4 µM 5.33E-5 10 8.08E-6
20 SGTC_410 α-linolenic acid 4.26 100.0 µM 6.57E-5 excess fatty acid 28 1.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.45E-21 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.157 5.99E-20 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.141 2.72E-16 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.133 1.01E-14 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.128 1.07E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.123 7.38E-13 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.123 7.66E-13 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.123 8.43E-13 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.123 9.94E-13 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.120 2.76E-12 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.119 3.90E-12 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.119 5.54E-12 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.118 7.30E-12 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.116 1.69E-11 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.115 2.05E-11 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication