YCR025C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR025C / YCR025C

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.51|P-value:1.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.78|P-value:4.33E-9 ID:SGTC_144|Compound:4161-2749|FD-Score:4.30|P-value:9.84E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.69|P-value:7.49E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.51|P-value:2.61E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.28|P-value:5.86E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:5.24|P-value:9.29E-8 ID:SGTC_557|Compound:1315-0110|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.27|P-value:6.07E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.22|P-value:7.37E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.04|P-value:3.12E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.30|P-value:3.70E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.63|P-value:1.66E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.59|P-value:1.30E-8 ID:SGTC_1034|Compound:k072-0165|FD-Score:10.60|P-value:9.85E-27 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.23|P-value:8.32E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.15|P-value:9.29E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.17|P-value:1.80E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.76|P-value:9.78E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.88|P-value:6.06E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.71|P-value:1.17E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.13|P-value:2.10E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.63|P-value:2.08E-6 ID:SGTC_1620|Compound:st003704|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:6.77|P-value:7.62E-12 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.13|P-value:2.14E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.35|P-value:4.64E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.58|P-value:2.74E-6 ID:SGTC_1808|Compound:st050063|FD-Score:3.91|P-value:5.28E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.41|P-value:5.94E-6 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.16|P-value:8.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.85|P-value:6.73E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.19|P-value:8.17E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.44|P-value:3.29E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.76|P-value:7.69E-12 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.17|P-value:3.86E-10 ID:SGTC_2699|Compound:st077704|FD-Score:-3.14|P-value:6.60E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.05|P-value:2.52E-7 ID:SGTC_2713|Compound:st079149|FD-Score:-3.25|P-value:4.49E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.95|P-value:4.52E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.06|P-value:2.45E-7 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.78|P-value:9.15E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.38|P-value:1.00E-10 ID:SGTC_2786|Compound:7743617|FD-Score:4.86|P-value:6.99E-7 ID:SGTC_2787|Compound:5284540|FD-Score:4.36|P-value:7.71E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.28|P-value:6.00E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.97|P-value:4.14E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.50|P-value:1.72E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.51|P-value:1.66E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.78|P-value:4.33E-9 ID:SGTC_144|Compound:4161-2749|FD-Score:4.30|P-value:9.84E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.69|P-value:7.49E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.51|P-value:2.61E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.28|P-value:5.86E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:5.24|P-value:9.29E-8 ID:SGTC_557|Compound:1315-0110|FD-Score:3.38|P-value:4.18E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.27|P-value:6.07E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.96|P-value:4.36E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.22|P-value:7.37E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.30|P-value:5.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.04|P-value:3.12E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.65|P-value:1.53E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.29|P-value:3.80E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.30|P-value:3.70E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.63|P-value:1.66E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.59|P-value:1.30E-8 ID:SGTC_1034|Compound:k072-0165|FD-Score:10.60|P-value:9.85E-27 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.23|P-value:8.32E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.15|P-value:9.29E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.17|P-value:1.80E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.76|P-value:9.78E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.88|P-value:6.06E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.71|P-value:1.17E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.13|P-value:2.10E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.63|P-value:2.08E-6 ID:SGTC_1620|Compound:st003704|FD-Score:4.08|P-value:2.61E-5 ID:SGTC_1672|Compound:st016598|FD-Score:6.77|P-value:7.62E-12 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.13|P-value:2.14E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.24|P-value:6.81E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.35|P-value:4.64E-4 ID:SGTC_1755|Compound:st041960|FD-Score:4.58|P-value:2.74E-6 ID:SGTC_1808|Compound:st050063|FD-Score:3.91|P-value:5.28E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.41|P-value:5.94E-6 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.75|P-value:1.00E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.16|P-value:8.88E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.69|P-value:1.28E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.85|P-value:6.73E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.19|P-value:8.17E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.87|P-value:6.34E-5 ID:SGTC_2308|Compound:7584454|FD-Score:3.44|P-value:3.29E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.76|P-value:7.69E-12 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.17|P-value:3.86E-10 ID:SGTC_2699|Compound:st077704|FD-Score:-3.14|P-value:6.60E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.05|P-value:2.52E-7 ID:SGTC_2713|Compound:st079149|FD-Score:-3.25|P-value:4.49E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.95|P-value:4.52E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.06|P-value:2.45E-7 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.78|P-value:9.15E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.38|P-value:1.00E-10 ID:SGTC_2786|Compound:7743617|FD-Score:4.86|P-value:6.99E-7 ID:SGTC_2787|Compound:5284540|FD-Score:4.36|P-value:7.71E-6 ID:SGTC_2802|Compound:7925815|FD-Score:3.28|P-value:6.00E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.97|P-value:4.14E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.50|P-value:1.72E-4

Top fitness defect scores for YCR025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1034 k072-0165 10.60 12.7 µM 9.85E-27 Golgi 1 9.96E-27
2 SGTC_1672 st016598 6.77 6.5 µM 7.62E-12 endomembrane recycling 25 6.65E-12
3 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 6.76 54.6 µM 7.69E-12 RPP1 & pyrimidine depletion 4 6.71E-12
4 SGTC_2780 5215298 6.38 71.4 µM 1.00E-10 5 8.69E-11
5 SGTC_2561 acetosyringone 6.17 100.0 µM 3.86E-10 4 3.34E-10
6 SGTC_58 0957-0393 5.78 9.0 µM 4.33E-9 cell wall 225 3.73E-9
7 SGTC_145 3737-0113 5.69 38.4 µM 7.49E-9 DNA intercalators 31 6.45E-9
8 SGTC_1016 4226-1401 5.59 38.0 µM 1.30E-8 RNA pol III & RNase P/MRP 2 1.12E-8
9 SGTC_474 dl-dihydrosphingosine 5.24 5.0 µM 9.29E-8 13 7.99E-8
10 SGTC_2757 clomiphene 5.06 4.2 µM 2.45E-7 fatty acid desaturase (OLE1) 19 2.11E-7
11 SGTC_2700 st077718 5.05 96.8 µM 2.52E-7 1 2.17E-7
12 SGTC_2786 7743617 4.86 45.5 µM 6.99E-7 10 6.01E-7
13 SGTC_1613 st002381 4.63 52.1 µM 2.08E-6 12 1.79E-6
14 SGTC_1755 st041960 4.58 45.2 µM 2.74E-6 14 2.36E-6
15 SGTC_1819 st053448 4.41 58.6 µM 5.94E-6 amide catabolism 13 5.12E-6
16 SGTC_2787 5284540 4.36 71.4 µM 7.71E-6 19 6.64E-6
17 SGTC_144 4161-2749 4.30 112.4 µM 9.84E-6 DNA intercalators 21 8.49E-6
18 SGTC_1237 0330-0133 4.17 46.1 µM 1.80E-5 ergosterol biosynthesis 21 1.55E-5
19 SGTC_1589 2',5'-dimethoxyflavone 4.13 47.2 µM 2.10E-5 13 1.81E-5
20 SGTC_1680 diphenhydramine 4.13 100.0 µM 2.14E-5 NEO1 23 1.84E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.36E-14 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.125 4.21E-13 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 9.06E-11 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.111 9.98E-11 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
0.111 1.13E-10 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.111 1.20E-10 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.107 4.83E-10 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.105 1.09E-9 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.104 1.56E-9 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.104 1.75E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.103 2.26E-9 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099 9.03E-9 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.099 8.71E-9 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.099 9.97E-9 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.096 2.17E-8 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain