YCR026C / NPP1

Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR026C / NPP1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.15|P-value:4.28E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.09|P-value:5.34E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.69|P-value:2.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.26|P-value:1.27E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:3.41|P-value:6.41E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.78|P-value:1.11E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.23|P-value:3.01E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.20|P-value:8.63E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.35|P-value:7.73E-4 ID:SGTC_276|Compound:colchicine|FD-Score:5.16|P-value:4.78E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:3.96|P-value:8.92E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:4.59|P-value:6.61E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.70|P-value:2.33E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.57|P-value:3.76E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.95|P-value:1.30E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.34|P-value:7.94E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.33|P-value:8.26E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.55|P-value:3.97E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.99|P-value:7.85E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.44|P-value:5.80E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.50|P-value:4.77E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:6.68|P-value:9.80E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.36|P-value:1.79E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.59|P-value:3.43E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.25|P-value:7.33E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.81|P-value:1.61E-8 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.78|P-value:1.90E-8 ID:SGTC_1205|Compound:4161-2785|FD-Score:6.32|P-value:8.92E-10 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.40|P-value:6.59E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:7.96|P-value:1.53E-14 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.38|P-value:1.63E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:2.79E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.67|P-value:2.60E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.43|P-value:5.94E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.36|P-value:7.62E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.24|P-value:2.90E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.35|P-value:7.79E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.59|P-value:5.42E-8 ID:SGTC_2279|Compound:7948423|FD-Score:3.40|P-value:6.68E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.82|P-value:2.37E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.63|P-value:3.00E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.37|P-value:7.29E-4 ID:SGTC_2389|Compound:9091542|FD-Score:5.50|P-value:8.27E-8 ID:SGTC_2421|Compound:5690543|FD-Score:-4.03|P-value:4.21E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.37|P-value:7.38E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.51|P-value:4.51E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.94|P-value:1.35E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.82|P-value:1.54E-8 ID:SGTC_2641|Compound:levomentholum|FD-Score:5.03|P-value:9.03E-7 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.73|P-value:2.09E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:2.63E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.75|P-value:1.27E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.33|P-value:8.20E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.03|P-value:6.71E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_2809|Compound:7964133|FD-Score:6.33|P-value:8.42E-10 ID:SGTC_2840|Compound:9008771|FD-Score:3.51|P-value:4.48E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.36|P-value:7.52E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.22|P-value:8.01E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.33|P-value:5.65E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.97|P-value:1.20E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.69|P-value:4.25E-6 ID:SGTC_3094|Compound:9117742|FD-Score:3.66|P-value:2.66E-4 ID:SGTC_3095|Compound:9117207|FD-Score:4.72|P-value:3.81E-6 ID:SGTC_3219|Compound:9131112|FD-Score:4.15|P-value:4.14E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:4.15|P-value:4.28E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.09|P-value:5.34E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.69|P-value:2.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.26|P-value:1.27E-9 ID:SGTC_88|Compound:0180-0332|FD-Score:3.41|P-value:6.41E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.78|P-value:1.11E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.23|P-value:3.01E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.20|P-value:8.63E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.35|P-value:7.73E-4 ID:SGTC_276|Compound:colchicine|FD-Score:5.16|P-value:4.78E-7 ID:SGTC_288|Compound:1315-0019|FD-Score:3.96|P-value:8.92E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:4.59|P-value:6.61E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:3.72|P-value:2.13E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.72|P-value:2.15E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.70|P-value:2.33E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.57|P-value:3.76E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:4.95|P-value:1.30E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.34|P-value:7.94E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.33|P-value:8.26E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.55|P-value:3.97E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.99|P-value:7.85E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.44|P-value:5.80E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.50|P-value:4.77E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:6.68|P-value:9.80E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.36|P-value:1.79E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.59|P-value:3.43E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.25|P-value:7.33E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.81|P-value:1.61E-8 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.90|P-value:1.13E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:5.78|P-value:1.90E-8 ID:SGTC_1205|Compound:4161-2785|FD-Score:6.32|P-value:8.92E-10 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.40|P-value:6.59E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:7.96|P-value:1.53E-14 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.78|P-value:1.71E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.43|P-value:6.04E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.38|P-value:1.63E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.78|P-value:2.79E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.67|P-value:2.60E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.43|P-value:5.94E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.60|P-value:3.37E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.36|P-value:7.62E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.24|P-value:2.90E-5 ID:SGTC_2127|Compound:5253358|FD-Score:3.35|P-value:7.79E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.59|P-value:5.42E-8 ID:SGTC_2279|Compound:7948423|FD-Score:3.40|P-value:6.68E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.82|P-value:2.37E-6 ID:SGTC_2363|Compound:9053361|FD-Score:3.63|P-value:3.00E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.37|P-value:7.29E-4 ID:SGTC_2389|Compound:9091542|FD-Score:5.50|P-value:8.27E-8 ID:SGTC_2421|Compound:5690543|FD-Score:-4.03|P-value:4.21E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.37|P-value:7.38E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.51|P-value:4.51E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.94|P-value:1.35E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.82|P-value:1.54E-8 ID:SGTC_2641|Compound:levomentholum|FD-Score:5.03|P-value:9.03E-7 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.73|P-value:2.09E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:2.63E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.75|P-value:1.27E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.33|P-value:8.20E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.03|P-value:6.71E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.62|P-value:3.06E-4 ID:SGTC_2809|Compound:7964133|FD-Score:6.33|P-value:8.42E-10 ID:SGTC_2840|Compound:9008771|FD-Score:3.51|P-value:4.48E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.36|P-value:7.52E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.22|P-value:8.01E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.33|P-value:5.65E-4 ID:SGTC_3043|Compound:9092303|FD-Score:4.97|P-value:1.20E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.69|P-value:4.25E-6 ID:SGTC_3094|Compound:9117742|FD-Score:3.66|P-value:2.66E-4 ID:SGTC_3095|Compound:9117207|FD-Score:4.72|P-value:3.81E-6 ID:SGTC_3219|Compound:9131112|FD-Score:4.15|P-value:4.14E-5

Top fitness defect scores for YCR026C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1243 0416-0003 7.96 5.7 µM 1.53E-14 PDR1 3 8.60E-16
2 SGTC_1040 k898-0338 6.68 155.0 µM 9.80E-11 2 1.20E-11
3 SGTC_2809 7964133 6.33 13.0 µM 8.42E-10 60S ribosome export 4 1.25E-10
4 SGTC_1205 4161-2785 6.32 76.0 µM 8.92E-10 6 1.33E-10
5 SGTC_58 0957-0393 6.26 9.0 µM 1.27E-9 cell wall 199 1.96E-10
6 SGTC_2583 asiatic acid 5.82 100.0 µM 1.54E-8 15 2.96E-9
7 SGTC_1178 0988-0033 5.81 191.0 µM 1.61E-8 4 3.11E-9
8 SGTC_1199 1638-0010 5.78 4.5 µM 1.90E-8 endomembrane recycling 2 3.72E-9
9 SGTC_2274 7947094 5.59 46.1 µM 5.42E-8 4 1.17E-8
10 SGTC_2389 9091542 5.50 195.5 µM 8.27E-8 iron homeostasis 19 1.85E-8
11 SGTC_276 colchicine 5.16 750.0 µM 4.78E-7 6 1.25E-7
12 SGTC_2641 levomentholum 5.03 100.0 µM 9.03E-7 4 2.51E-7
13 SGTC_3043 9092303 4.97 49.5 µM 1.20E-6 4 3.42E-7
14 SGTC_641 4092-0595 4.95 30.0 µM 1.30E-6 6 3.75E-7
15 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.94 100.0 µM 1.35E-6 10 3.89E-7
16 SGTC_2321 7390090 4.82 138.8 µM 2.37E-6 11 7.21E-7
17 SGTC_1547 harmine 4.78 94.2 µM 2.79E-6 ergosterol biosynthesis 24 8.60E-7
18 SGTC_3095 9117207 4.72 49.5 µM 3.81E-6 3 1.21E-6
19 SGTC_3047 9092122 4.69 49.5 µM 4.25E-6 8 1.36E-6
20 SGTC_385 1494-0393 4.59 12.4 µM 6.61E-6 11 2.20E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.07E-11 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.16E-11 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.113 5.30E-11 YBR295W PCA1 hom Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function
0.113 6.59E-11 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.109 2.08E-10 YBR300C_d YBR300C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
0.108 2.90E-10 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
0.107 5.17E-10 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.100 7.28E-9 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.098 1.24E-8 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.098 1.34E-8 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.094 4.64E-8 YBR297W MAL33 hom MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
0.093 6.42E-8 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.093 7.58E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.091 1.18E-7 YCR024C-A PMP1 hom Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication
0.091 1.28E-7 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1