YCR028C / FEN2

Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR028C / FEN2

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:-4.69|P-value:1.79E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-8.04|P-value:6.68E-13 ID:SGTC_132|Compound:0417-1715|FD-Score:3.55|P-value:8.40E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.49|P-value:9.94E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.84|P-value:3.33E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.16|P-value:1.14E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.66|P-value:6.31E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.07|P-value:1.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.53|P-value:9.35E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.94|P-value:2.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.73|P-value:1.58E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-5.11|P-value:3.32E-6 ID:SGTC_1649|Compound:st011737|FD-Score:-4.44|P-value:4.57E-5 ID:SGTC_1653|Compound:st012112|FD-Score:-3.68|P-value:6.08E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.54|P-value:9.17E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.71|P-value:5.04E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.82|P-value:3.64E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.71|P-value:5.46E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.78|P-value:4.37E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.75|P-value:4.75E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-4.14|P-value:1.36E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.44|P-value:8.06E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.13|P-value:3.05E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.96|P-value:2.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.59|P-value:7.31E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.80|P-value:3.82E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-4.16|P-value:1.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.53|P-value:3.00E-5 ID:SGTC_2437|Compound:5741531|FD-Score:-5.14|P-value:2.94E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-7.58|P-value:1.20E-11 ID:SGTC_2450|Compound:5739737|FD-Score:-4.19|P-value:1.12E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:1.92E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.54|P-value:9.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.19|P-value:1.04E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.85|P-value:3.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-9.06|P-value:6.53E-16 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.73|P-value:4.74E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.50|P-value:9.76E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.72|P-value:4.94E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.90|P-value:2.77E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.33|P-value:6.80E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.45|P-value:4.46E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.64|P-value:6.28E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.59|P-value:7.78E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.39|P-value:5.54E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.14|P-value:1.22E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.01|P-value:2.06E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-4.69|P-value:1.79E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-8.04|P-value:6.68E-13 ID:SGTC_132|Compound:0417-1715|FD-Score:3.55|P-value:8.40E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.49|P-value:9.94E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.84|P-value:3.33E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:4.16|P-value:1.14E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.66|P-value:6.31E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.07|P-value:1.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.53|P-value:9.35E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.94|P-value:2.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.73|P-value:1.58E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-5.11|P-value:3.32E-6 ID:SGTC_1649|Compound:st011737|FD-Score:-4.44|P-value:4.57E-5 ID:SGTC_1653|Compound:st012112|FD-Score:-3.68|P-value:6.08E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.54|P-value:9.17E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.71|P-value:5.04E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.82|P-value:3.64E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.71|P-value:5.46E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-3.78|P-value:4.37E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.75|P-value:4.75E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-4.14|P-value:1.36E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-5.44|P-value:8.06E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.13|P-value:3.05E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.96|P-value:2.28E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.59|P-value:7.31E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.80|P-value:3.82E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-4.16|P-value:1.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.53|P-value:3.00E-5 ID:SGTC_2437|Compound:5741531|FD-Score:-5.14|P-value:2.94E-6 ID:SGTC_2438|Compound:5259590|FD-Score:-7.58|P-value:1.20E-11 ID:SGTC_2450|Compound:5739737|FD-Score:-4.19|P-value:1.12E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:1.92E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-3.54|P-value:9.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:4.19|P-value:1.04E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.85|P-value:3.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-9.06|P-value:6.53E-16 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.73|P-value:4.74E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.50|P-value:9.76E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.72|P-value:4.94E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.90|P-value:2.77E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.33|P-value:6.80E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.45|P-value:4.46E-5 ID:SGTC_2900|Compound:5328528|FD-Score:3.64|P-value:6.28E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.59|P-value:7.78E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-4.39|P-value:5.54E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.14|P-value:1.22E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.01|P-value:2.06E-4

Top fitness defect scores for YCR028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 4.53 3.5 µM 3.00E-5 49 2.91E-6
2 SGTC_2549 cedrol 4.19 20.9 µM 1.04E-4 14 1.40E-5
3 SGTC_599 1935-0052 4.16 86.5 µM 1.14E-4 16 1.57E-5
4 SGTC_3145 9085516 4.14 49.5 µM 1.22E-4 fatty acid desaturase (OLE1) 22 1.71E-5
5 SGTC_2453 5731132 4.01 22.2 µM 1.92E-4 19 3.03E-5
6 SGTC_2253 7938677 3.96 135.8 µM 2.28E-4 9 3.77E-5
7 SGTC_2791 5663188 3.90 71.4 µM 2.77E-4 RPP1 & pyrimidine depletion 21 4.84E-5
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.85 100.0 µM 3.22E-4 36 5.84E-5
9 SGTC_451 chloral hydrate 3.84 100.0 µM 3.33E-4 58 6.10E-5
10 SGTC_1848 st056003 3.82 16.4 µM 3.64E-4 18 6.81E-5
11 SGTC_2358 9037157 3.80 4.0 µM 3.82E-4 38 7.23E-5
12 SGTC_2767 sibutramine 3.73 71.5 µM 4.74E-4 25 9.49E-5
13 SGTC_2787 5284540 3.72 71.4 µM 4.94E-4 33 1.00E-4
14 SGTC_1846 st056244 3.71 14.8 µM 5.04E-4 38 1.03E-4
15 SGTC_2900 5328528 3.64 85.3 µM 6.28E-4 Golgi 39 1.35E-4
16 SGTC_2282 7944268 3.59 200.0 µM 7.31E-4 RPP1 & pyrimidine depletion 46 1.64E-4
17 SGTC_132 0417-1715 3.55 25.8 µM 8.40E-4 RPP1 & pyrimidine depletion 31 1.95E-4
18 SGTC_2772 vinpocetine 3.50 57.1 µM 9.76E-4 36 2.36E-4
19 SGTC_445 e6 berbamine 3.49 66.0 µM 9.94E-4 NEO1-PIK1 144 2.41E-4
20 SGTC_1063 disulfiram 3.47 1.8 µM 0.00106 39 2.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.43E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.103 2.07E-9 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.101 4.16E-9 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.093 7.34E-8 YHR082C KSP1 hom Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.092 1.07E-7 YOR170W_d YOR170W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4
0.091 1.36E-7 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.090 1.51E-7 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.087 4.10E-7 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.082 2.16E-6 YML009C-A_d YML009C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.08E-6 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.078 5.51E-6 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.078 6.14E-6 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.074 1.76E-5 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.071 3.70E-5 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.071 4.33E-5 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress