YCR028C-A / RIM1

Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR028C-A / RIM1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.22|P-value:1.95E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.81|P-value:6.95E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.40|P-value:2.77E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.20|P-value:9.09E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.03|P-value:1.15E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.15|P-value:2.47E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.19|P-value:2.16E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.54|P-value:6.84E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.74|P-value:8.33E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.33|P-value:4.79E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:3.65E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.90|P-value:3.01E-14 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.14|P-value:2.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.87|P-value:4.86E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.95|P-value:3.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.03|P-value:9.59E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.76|P-value:6.75E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.71|P-value:9.12E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.60|P-value:1.25E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.42|P-value:2.58E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.00|P-value:3.26E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.89|P-value:1.99E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.19|P-value:2.15E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.02|P-value:3.62E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.94|P-value:4.00E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.63|P-value:4.05E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.99|P-value:4.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.42|P-value:1.55E-10 ID:SGTC_1939|Compound:st074455|FD-Score:4.19|P-value:2.13E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.23|P-value:5.47E-6 ID:SGTC_2433|Compound:5607874|FD-Score:4.63|P-value:4.88E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-4.97|P-value:1.18E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.90|P-value:4.54E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.44|P-value:9.54E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.47|P-value:8.70E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-6.56|P-value:1.28E-8 ID:SGTC_2844|Compound:9010103|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-10.10|P-value:6.12E-18 ID:SGTC_3056|Compound:9094900|FD-Score:4.88|P-value:2.03E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-7.08|P-value:9.45E-10 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.22|P-value:1.95E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.81|P-value:6.95E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.40|P-value:2.77E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:6.20|P-value:9.09E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:5.03|P-value:1.15E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:4.15|P-value:2.47E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.19|P-value:2.16E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.54|P-value:6.84E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.74|P-value:8.33E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.33|P-value:4.79E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.33|P-value:3.65E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:8.90|P-value:3.01E-14 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.14|P-value:2.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.87|P-value:4.86E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.95|P-value:3.87E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.03|P-value:9.59E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.76|P-value:6.75E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.71|P-value:9.12E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:5.60|P-value:1.25E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.42|P-value:2.58E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.00|P-value:3.26E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.89|P-value:1.99E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.19|P-value:2.15E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.02|P-value:3.62E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.94|P-value:4.00E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.63|P-value:4.05E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.99|P-value:4.07E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.42|P-value:1.55E-10 ID:SGTC_1939|Compound:st074455|FD-Score:4.19|P-value:2.13E-4 ID:SGTC_2183|Compound:6420625|FD-Score:5.23|P-value:5.47E-6 ID:SGTC_2433|Compound:5607874|FD-Score:4.63|P-value:4.88E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-4.97|P-value:1.18E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.90|P-value:4.54E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.44|P-value:9.54E-5 ID:SGTC_2712|Compound:st079126|FD-Score:4.47|P-value:8.70E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-6.56|P-value:1.28E-8 ID:SGTC_2844|Compound:9010103|FD-Score:4.86|P-value:2.16E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-10.10|P-value:6.12E-18 ID:SGTC_3056|Compound:9094900|FD-Score:4.88|P-value:2.03E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-7.08|P-value:9.45E-10

Top fitness defect scores for YCR028C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 8.90 1.1 µM 3.01E-14 mitochondrial stress 66 2.67E-19
2 SGTC_236 1509-0011 6.33 5.3 µM 4.79E-8 285 1.19E-10
3 SGTC_118 0083-0097 6.20 135.3 µM 9.09E-8 translation 19 2.89E-10
4 SGTC_967 1306-0166 5.60 352.0 µM 1.25E-6 5 1.10E-8
5 SGTC_1016 4226-1401 5.42 38.0 µM 2.58E-6 RNA pol III & RNase P/MRP 5 3.03E-8
6 SGTC_116 0155-0182 5.40 31.8 µM 2.77E-6 mitochondrial response to ROS 34 3.34E-8
7 SGTC_275 trichlorophene 5.33 5.7 µM 3.65E-6 mitochondrial stress 150 4.90E-8
8 SGTC_2183 6420625 5.23 130.5 µM 5.47E-6 mitochondrial processes 26 8.61E-8
9 SGTC_119 0121-0043 5.03 24.8 µM 1.15E-5 mitochondrial stress 52 2.41E-7
10 SGTC_1150 3909-7983 4.89 10.9 µM 1.99E-5 9 5.15E-7
11 SGTC_3056 9094900 4.88 49.5 µM 2.03E-5 7 5.32E-7
12 SGTC_2844 9010103 4.86 26.0 µM 2.16E-5 12 5.79E-7
13 SGTC_2433 5607874 4.63 27.8 µM 4.88E-5 10 1.79E-6
14 SGTC_195 4234-0266 4.54 16.6 µM 6.84E-5 19 2.86E-6
15 SGTC_2712 st079126 4.47 47.7 µM 8.70E-5 8 3.98E-6
16 SGTC_2704 st078022 4.44 71.1 µM 9.54E-5 10 4.53E-6
17 SGTC_28 pentachloropyridine N-oxide 4.22 1.6 µM 1.95E-4 TSC3-RPN4 60 1.22E-5
18 SGTC_1939 st074455 4.19 53.6 µM 2.13E-4 24 1.37E-5
19 SGTC_1178 0988-0033 4.19 191.0 µM 2.15E-4 22 1.39E-5
20 SGTC_173 1273-0061 4.19 2.7 µM 2.16E-4 mitochondrial stress 178 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 8.89E-109 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.362 2.60E-104 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.358 8.99E-102 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.356 7.16E-101 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.355 4.72E-100 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.352 2.80E-98 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.347 1.14E-95 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.347 2.43E-95 YIL014C-A_p YIL014C-A_p hom Putative protein of unknown function
0.345 2.82E-94 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.344 1.45E-93 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.341 2.12E-92 YHR051W COX6 hom Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
0.341 5.22E-92 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.338 1.81E-90 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.335 6.94E-89 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.333 9.00E-88 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation