YCR030C / SYP1

Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR030C / SYP1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.63|P-value:1.12E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.17|P-value:6.45E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.21|P-value:5.65E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.33|P-value:3.64E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.91|P-value:3.41E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-5.88|P-value:9.85E-10 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.59|P-value:1.30E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.07|P-value:1.26E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.02|P-value:8.60E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.07|P-value:7.13E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.70|P-value:8.47E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:3.33E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.41|P-value:3.50E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_1731|Compound:st035964|FD-Score:7.80|P-value:4.19E-16 ID:SGTC_1735|Compound:st034310|FD-Score:4.55|P-value:1.22E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-8.33|P-value:8.27E-18 ID:SGTC_2035|Compound:5154463|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.15|P-value:6.92E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.14|P-value:1.26E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.00|P-value:2.33E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-4.60|P-value:1.40E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.08|P-value:6.91E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.06|P-value:8.55E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-3.67|P-value:9.60E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-3.14|P-value:7.15E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:3.47E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.16|P-value:6.61E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.10|P-value:8.23E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.63|P-value:1.12E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.17|P-value:6.45E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.21|P-value:5.65E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.33|P-value:3.64E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.91|P-value:3.41E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-5.88|P-value:9.85E-10 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.59|P-value:1.29E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.59|P-value:1.30E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.07|P-value:1.26E-5 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.02|P-value:8.60E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.07|P-value:7.13E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.70|P-value:8.47E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:3.33E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.41|P-value:3.50E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.89|P-value:2.76E-5 ID:SGTC_1731|Compound:st035964|FD-Score:7.80|P-value:4.19E-16 ID:SGTC_1735|Compound:st034310|FD-Score:4.55|P-value:1.22E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-8.33|P-value:8.27E-18 ID:SGTC_2035|Compound:5154463|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.15|P-value:6.92E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.14|P-value:1.26E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.56|P-value:1.09E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.00|P-value:2.33E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-4.60|P-value:1.40E-6 ID:SGTC_2794|Compound:7785382|FD-Score:3.08|P-value:6.91E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.06|P-value:8.55E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-3.67|P-value:9.60E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-3.14|P-value:7.15E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:3.47E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.03|P-value:8.33E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.16|P-value:6.61E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.29|P-value:4.23E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.10|P-value:8.23E-4

Top fitness defect scores for YCR030C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1731 st035964 7.80 63.0 µM 4.19E-16 2 3.08E-15
2 SGTC_2802 7925815 5.06 54.5 µM 8.55E-8 15 2.15E-7
3 SGTC_1735 st034310 4.55 56.8 µM 1.22E-6 Golgi 14 2.64E-6
4 SGTC_1181 1222-0449 4.07 220.0 µM 1.26E-5 25 2.39E-5
5 SGTC_1728 st035614 3.89 33.8 µM 2.76E-5 54 5.00E-5
6 SGTC_2649 anisomycin 3.56 9.6 µM 1.09E-4 15 1.83E-4
7 SGTC_2794 7785382 3.08 27.3 µM 6.91E-4 84 0.00104
8 SGTC_1210 3013-0140 3.07 750.0 nM 7.13E-4 31 0.00107
9 SGTC_2035 5154463 3.04 94.6 µM 7.78E-4 53 0.00116
10 SGTC_2947 9072639 3.03 7.7 µM 8.33E-4 tubulin folding & SWR complex 100 0.00124
11 SGTC_1208 2323-2347 3.02 50.3 µM 8.60E-4 40 0.00128
12 SGTC_1176 0848-0131 2.96 83.3 µM 0.00106 Golgi 65 0.00155
13 SGTC_1636 st007707 2.93 68.9 µM 0.00118 104 0.00172
14 SGTC_1794 st048918 2.88 76.9 µM 0.00135 41 0.00196
15 SGTC_2462 5162487 2.87 171.8 µM 0.00143 63 0.00207
16 SGTC_2106 5357045 2.85 167.3 µM 0.00150 64 0.00216
17 SGTC_2374 9071832 2.84 200.0 µM 0.00157 endomembrane recycling 42 0.00226
18 SGTC_2563 tomatine 2.79 8.5 µM 0.00183 140 0.00260
19 SGTC_1795 st049545 2.75 62.3 µM 0.00208 TSC3-RPN4 64 0.00294
20 SGTC_2037 5169046 2.68 200.0 µM 0.00267 60S ribosome export 66 0.00372

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 1.79E-43 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.214 6.01E-36 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.201 9.20E-32 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.186 1.78E-27 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.185 4.03E-27 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.175 1.24E-24 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.173 5.38E-24 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.170 3.61E-23 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.170 5.18E-23 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.164 1.51E-21 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.163 3.48E-21 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.160 1.08E-20 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.157 6.09E-20 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.157 7.53E-20 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.156 1.19E-19 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination