YCR031C / RPS14A

Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR031C / RPS14A

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.91|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.74|P-value:6.32E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.23|P-value:4.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.46|P-value:1.78E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.63|P-value:9.77E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:3.23|P-value:4.64E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.41|P-value:2.36E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.78|P-value:5.30E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.44|P-value:2.08E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.73|P-value:5.97E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.90|P-value:3.12E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.34|P-value:3.04E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.47|P-value:1.76E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.08|P-value:1.32E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.14|P-value:6.61E-8 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.38|P-value:2.63E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.13|P-value:6.72E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.25|P-value:4.36E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.37|P-value:2.74E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.06|P-value:8.63E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.02|P-value:9.83E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.28|P-value:3.92E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.79|P-value:5.03E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.45|P-value:2.03E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.39|P-value:2.54E-4 ID:SGTC_1792|Compound:st045773|FD-Score:8.30|P-value:7.55E-18 ID:SGTC_1826|Compound:st055655|FD-Score:3.53|P-value:1.49E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.16|P-value:9.74E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.12|P-value:6.84E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.19|P-value:5.30E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.86|P-value:9.75E-13 ID:SGTC_1917|Compound:st066507|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.23|P-value:4.33E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.34|P-value:3.13E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.81|P-value:3.98E-7 ID:SGTC_1953|Compound:st076800|FD-Score:-4.32|P-value:4.22E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.67|P-value:8.29E-5 ID:SGTC_2072|Compound:5231554|FD-Score:4.64|P-value:9.49E-7 ID:SGTC_2195|Compound:6536160|FD-Score:3.05|P-value:8.76E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.50|P-value:1.53E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.69|P-value:7.18E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.49|P-value:1.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.54|P-value:1.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.97|P-value:2.30E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.14|P-value:6.58E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.80|P-value:4.14E-7 ID:SGTC_2702|Compound:st077768|FD-Score:3.44|P-value:2.10E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-4.07|P-value:1.40E-5 ID:SGTC_2709|Compound:st078560|FD-Score:5.33|P-value:2.26E-8 ID:SGTC_2800|Compound:7887935|FD-Score:-4.70|P-value:6.34E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-3.09|P-value:7.14E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.44|P-value:2.12E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.99|P-value:2.16E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.46|P-value:1.98E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.05|P-value:1.67E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.32|P-value:3.34E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-4.59|P-value:1.16E-6 ID:SGTC_3138|Compound:9097216|FD-Score:5.58|P-value:5.28E-9 ID:SGTC_3144|Compound:9087057|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.94|P-value:2.04E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-3.39|P-value:2.41E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.02|P-value:9.93E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.09|P-value:7.66E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.91|P-value:3.09E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:3.74|P-value:6.32E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.58|P-value:1.19E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.23|P-value:4.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.46|P-value:1.78E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.63|P-value:9.77E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:3.23|P-value:4.64E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.41|P-value:2.36E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.60|P-value:1.11E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.13|P-value:6.64E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.78|P-value:5.30E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.44|P-value:2.08E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.73|P-value:5.97E-7 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.90|P-value:3.12E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.34|P-value:3.04E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.47|P-value:1.76E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.08|P-value:1.32E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.14|P-value:6.61E-8 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.38|P-value:2.63E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.50|P-value:1.64E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.51|P-value:1.59E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.13|P-value:6.72E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.25|P-value:4.36E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.37|P-value:2.74E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.06|P-value:8.63E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.02|P-value:9.83E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.28|P-value:3.92E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.79|P-value:5.03E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.45|P-value:2.03E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.39|P-value:2.54E-4 ID:SGTC_1792|Compound:st045773|FD-Score:8.30|P-value:7.55E-18 ID:SGTC_1826|Compound:st055655|FD-Score:3.53|P-value:1.49E-4 ID:SGTC_1837|Compound:st055472|FD-Score:4.16|P-value:9.74E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.12|P-value:6.84E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.19|P-value:5.30E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.86|P-value:9.75E-13 ID:SGTC_1917|Compound:st066507|FD-Score:3.26|P-value:4.18E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.23|P-value:4.33E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.34|P-value:3.13E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.81|P-value:3.98E-7 ID:SGTC_1953|Compound:st076800|FD-Score:-4.32|P-value:4.22E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.18|P-value:5.31E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.67|P-value:8.29E-5 ID:SGTC_2072|Compound:5231554|FD-Score:4.64|P-value:9.49E-7 ID:SGTC_2195|Compound:6536160|FD-Score:3.05|P-value:8.76E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.50|P-value:1.53E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.69|P-value:7.18E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.49|P-value:1.73E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.54|P-value:1.34E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.97|P-value:2.30E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.14|P-value:6.58E-8 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.80|P-value:4.14E-7 ID:SGTC_2702|Compound:st077768|FD-Score:3.44|P-value:2.10E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-4.07|P-value:1.40E-5 ID:SGTC_2709|Compound:st078560|FD-Score:5.33|P-value:2.26E-8 ID:SGTC_2800|Compound:7887935|FD-Score:-4.70|P-value:6.34E-7 ID:SGTC_2856|Compound:9022925|FD-Score:-3.09|P-value:7.14E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.44|P-value:2.12E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.99|P-value:2.16E-5 ID:SGTC_3021|Compound:9087658|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.46|P-value:1.98E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.05|P-value:1.67E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.32|P-value:3.34E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-4.59|P-value:1.16E-6 ID:SGTC_3138|Compound:9097216|FD-Score:5.58|P-value:5.28E-9 ID:SGTC_3144|Compound:9087057|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.94|P-value:2.04E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-3.39|P-value:2.41E-4 ID:SGTC_3238|Compound:9133470|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.02|P-value:9.93E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.09|P-value:7.66E-4

Top fitness defect scores for YCR031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1792 st045773 8.30 43.6 µM 7.55E-18 2 5.00E-17
2 SGTC_1912 st060209 6.86 90.8 µM 9.75E-13 6 3.52E-12
3 SGTC_3138 9097216 5.58 49.5 µM 5.28E-9 2 1.23E-8
4 SGTC_2709 st078560 5.33 56.0 µM 2.26E-8 1 4.89E-8
5 SGTC_2592 piperlongumine 5.14 83.3 µM 6.58E-8 TSC3-RPN4 11 1.35E-7
6 SGTC_1107 amlodipine 5.14 47.0 µM 6.61E-8 12 1.36E-7
7 SGTC_3170 9103054 4.94 49.5 µM 2.04E-7 60S ribosome export 4 3.95E-7
8 SGTC_1948 st076329 4.81 66.6 µM 3.98E-7 12 7.46E-7
9 SGTC_2688 kanamycin b 4.80 96.7 µM 4.14E-7 calcium & mitochondrial duress 267 7.76E-7
10 SGTC_1031 k035-0009 4.73 16.0 µM 5.97E-7 13 1.10E-6
11 SGTC_2072 5231554 4.64 129.0 µM 9.49E-7 6 1.71E-6
12 SGTC_1837 st055472 4.16 66.5 µM 9.74E-6 14 1.56E-5
13 SGTC_3083 9117465 4.05 49.5 µM 1.67E-5 20 2.60E-5
14 SGTC_2996 9066192 3.99 71.4 µM 2.16E-5 31 3.33E-5
15 SGTC_2450 5739737 3.97 12.9 µM 2.30E-5 25 3.54E-5
16 SGTC_118 0083-0097 3.91 135.3 µM 3.09E-5 translation 137 4.67E-5
17 SGTC_1040 k898-0338 3.90 155.0 µM 3.12E-5 22 4.72E-5
18 SGTC_1746 st038117 3.79 42.0 µM 5.03E-5 36 7.44E-5
19 SGTC_963 1269-2853 3.78 151.0 µM 5.30E-5 29 7.82E-5
20 SGTC_194 1486-1323 3.74 56.9 µM 6.32E-5 24 9.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.00E-11 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.109 2.95E-10 YER110C KAP123 hom Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
0.108 3.05E-10 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.108 4.00E-10 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.102 2.86E-9 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.102 3.09E-9 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.101 4.07E-9 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.098 1.12E-8 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.098 1.47E-8 YHR010W RPL27A hom Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication
0.097 1.77E-8 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.097 2.01E-8 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.093 5.75E-8 YPL193W RSA1 hom Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
0.090 1.69E-7 YMR242W-A_p YMR242W-A_p hom Putative protein of unknown function
0.090 2.01E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.088 3.18E-7 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis