YCR032W / BPH1

Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR032W / BPH1

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:4.09|P-value:2.26E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.84|P-value:6.28E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.26|P-value:5.38E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.52|P-value:2.24E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.53|P-value:1.96E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.22|P-value:6.47E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.25|P-value:5.43E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.21|P-value:6.72E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.11|P-value:2.06E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.30|P-value:4.55E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.86|P-value:5.81E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.04E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.20|P-value:7.07E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.40|P-value:3.45E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.77|P-value:8.30E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.81|P-value:7.77E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.10|P-value:2.08E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.17|P-value:1.58E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.77|P-value:8.30E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.82|P-value:6.89E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.50|P-value:2.39E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.07|P-value:2.03E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:8.24|P-value:8.44E-17 ID:SGTC_1715|Compound:st032160|FD-Score:3.39|P-value:3.58E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.25|P-value:5.89E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.80|P-value:7.56E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.13|P-value:8.45E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.08|P-value:9.82E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.89|P-value:2.05E-9 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.36|P-value:6.84E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.33|P-value:4.53E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.02|P-value:3.00E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.35|P-value:4.20E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.18|P-value:7.09E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.96|P-value:3.88E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.52|P-value:2.24E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.52|P-value:2.23E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.21|P-value:1.33E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.33|P-value:4.50E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.09|P-value:2.26E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:3.84|P-value:6.28E-5 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.26|P-value:5.38E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.56|P-value:1.92E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.52|P-value:2.24E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.53|P-value:1.96E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.22|P-value:6.47E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.25|P-value:5.43E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.21|P-value:6.72E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.11|P-value:2.06E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.30|P-value:4.55E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.86|P-value:5.81E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.59|P-value:1.69E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.29|P-value:5.13E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.04E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.20|P-value:7.07E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.40|P-value:3.45E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.77|P-value:8.30E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.81|P-value:7.77E-7 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:4.09E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.10|P-value:2.08E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.17|P-value:1.58E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.77|P-value:8.30E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.10|P-value:9.88E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.82|P-value:6.89E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.50|P-value:2.39E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.07|P-value:2.03E-7 ID:SGTC_1573|Compound:oleylamine|FD-Score:8.24|P-value:8.44E-17 ID:SGTC_1715|Compound:st032160|FD-Score:3.39|P-value:3.58E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.25|P-value:5.89E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.53|P-value:2.11E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.80|P-value:7.56E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.13|P-value:8.45E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.08|P-value:9.82E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.89|P-value:2.05E-9 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.36|P-value:6.84E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.33|P-value:4.53E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_2704|Compound:st078022|FD-Score:4.02|P-value:3.00E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.35|P-value:4.20E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.18|P-value:7.09E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.96|P-value:3.88E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.52|P-value:2.24E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.52|P-value:2.23E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.21|P-value:1.33E-5 ID:SGTC_3204|Compound:9114183|FD-Score:3.33|P-value:4.50E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.62|P-value:1.53E-4

Top fitness defect scores for YCR032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1573 oleylamine 8.24 1.1 µM 8.44E-17 3 8.26E-17
2 SGTC_2502 avocadyne acetate 5.89 18.6 µM 2.05E-9 8 1.99E-9
3 SGTC_1528 arabinosylhypoxanthine 5.07 74.6 µM 2.03E-7 10 1.97E-7
4 SGTC_1168 k815-0004 4.81 80.5 µM 7.77E-7 DNA damage response 5 7.54E-7
5 SGTC_2558 carylophyllene oxide 4.36 100.0 µM 6.84E-6 8 6.65E-6
6 SGTC_2926 9010726 4.21 65.2 µM 1.33E-5 26 1.29E-5
7 SGTC_1284 0929-0043 4.17 16.0 µM 1.58E-5 19 1.54E-5
8 SGTC_594 1487-1584 4.11 10.8 µM 2.06E-5 21 2.00E-5
9 SGTC_1242 0402-0103 4.10 60.1 µM 2.08E-5 23 2.03E-5
10 SGTC_92 0063-0024 4.09 660.9 µM 2.26E-5 9 2.20E-5
11 SGTC_2704 st078022 4.02 71.1 µM 3.00E-5 12 2.92E-5
12 SGTC_2826 7992541 3.96 19.5 µM 3.88E-5 20 3.77E-5
13 SGTC_761 k216-0224 3.86 480.0 µM 5.81E-5 21 5.65E-5
14 SGTC_165 k038-0023 3.84 64.4 µM 6.28E-5 ubiquinone biosynthesis & proteasome 85 6.11E-5
15 SGTC_1447 4239-0816 3.82 81.9 µM 6.89E-5 33 6.71E-5
16 SGTC_1786 berberine 3.80 21.6 µM 7.56E-5 60S ribosome export 35 7.36E-5
17 SGTC_1105 epirubicin 3.77 18.1 µM 8.30E-5 anthracycline transcription coupled DNA repair 24 8.07E-5
18 SGTC_1288 0973-0013 3.77 65.5 µM 8.30E-5 21 8.08E-5
19 SGTC_3244 9134489 3.62 49.5 µM 1.53E-4 26 1.49E-4
20 SGTC_770 0389-1121 3.59 67.2 µM 1.69E-4 RPP1 & pyrimidine depletion 38 1.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.75E-10 YPL076W GPI2 het Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
0.100 6.27E-9 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.092 8.82E-8 YDR154C_d YDR154C_d hom Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
0.091 1.40E-7 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.078 6.11E-6 YLR064W PER33 hom Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
0.077 8.47E-6 YMR060C SAM37 hom Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
0.074 1.87E-5 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.072 3.33E-5 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.072 3.38E-5 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.071 3.60E-5 YNL224C SQS1 hom Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
0.067 1.06E-4 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.065 1.74E-4 YDR150W NUM1 hom Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
0.063 2.37E-4 YHR021C RPS27B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication
0.063 2.74E-4 YBL048W_d RRT1_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.063 2.80E-4 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p