YCR033W / SNT1

Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR033W / SNT1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:11.80|P-value:6.59E-31 ID:SGTC_137|Compound:0438-0332|FD-Score:3.91|P-value:6.51E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.33|P-value:5.96E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.77|P-value:1.56E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.75|P-value:1.29E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.22|P-value:1.83E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.39|P-value:2.62E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:9.40|P-value:2.05E-20 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.44|P-value:4.12E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.77|P-value:1.79E-11 ID:SGTC_358|Compound:0075-0058|FD-Score:4.51|P-value:5.23E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.28|P-value:1.51E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.54|P-value:2.81E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:6.42|P-value:1.70E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.49|P-value:5.99E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.66|P-value:2.63E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:5.17|P-value:2.17E-7 ID:SGTC_775|Compound:4577-0580|FD-Score:3.81|P-value:9.69E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.63|P-value:1.88E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.94|P-value:5.79E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.96|P-value:5.39E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.66|P-value:2.55E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.64|P-value:1.87E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.53|P-value:2.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.48|P-value:5.92E-17 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.36|P-value:5.01E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.15|P-value:2.49E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.68|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.01|P-value:4.45E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-3.61|P-value:2.17E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.26|P-value:7.09E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.43|P-value:7.46E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.59|P-value:2.19E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.46|P-value:3.54E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.87|P-value:9.68E-7 ID:SGTC_2051|Compound:5263410|FD-Score:4.45|P-value:6.80E-6 ID:SGTC_2058|Compound:5236698|FD-Score:4.27|P-value:1.50E-5 ID:SGTC_2105|Compound:5350118|FD-Score:-3.60|P-value:2.26E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.00|P-value:4.60E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.62|P-value:2.09E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.89|P-value:8.76E-7 ID:SGTC_2282|Compound:7944268|FD-Score:3.92|P-value:6.38E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.81|P-value:9.63E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.70|P-value:1.18E-53 ID:SGTC_2584|Compound:androsterone|FD-Score:3.98|P-value:4.95E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.84|P-value:9.13E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.74|P-value:1.01E-8 ID:SGTC_2858|Compound:9025781|FD-Score:3.95|P-value:5.54E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.90|P-value:6.88E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.99|P-value:4.73E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:4.47E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.41|P-value:4.20E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:11.80|P-value:6.59E-31 ID:SGTC_137|Compound:0438-0332|FD-Score:3.91|P-value:6.51E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.33|P-value:5.96E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.77|P-value:1.56E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.75|P-value:1.29E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.22|P-value:1.83E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:7.39|P-value:2.62E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:9.40|P-value:2.05E-20 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.44|P-value:4.12E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:6.77|P-value:1.79E-11 ID:SGTC_358|Compound:0075-0058|FD-Score:4.51|P-value:5.23E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.28|P-value:1.51E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.54|P-value:2.81E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:6.42|P-value:1.70E-10 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.49|P-value:5.99E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:4.66|P-value:2.63E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:5.17|P-value:2.17E-7 ID:SGTC_775|Compound:4577-0580|FD-Score:3.81|P-value:9.69E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.63|P-value:1.88E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.94|P-value:5.79E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.96|P-value:5.39E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.66|P-value:2.55E-6 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.64|P-value:1.87E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.53|P-value:2.79E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:8.48|P-value:5.92E-17 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.20|P-value:8.58E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.36|P-value:5.01E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.37|P-value:4.92E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.15|P-value:2.49E-5 ID:SGTC_1515|Compound:3460-0031|FD-Score:-3.68|P-value:1.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.01|P-value:4.45E-5 ID:SGTC_1613|Compound:st002381|FD-Score:-3.61|P-value:2.17E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.26|P-value:7.09E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.43|P-value:7.46E-6 ID:SGTC_1728|Compound:st035614|FD-Score:3.59|P-value:2.19E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.46|P-value:3.54E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.87|P-value:9.68E-7 ID:SGTC_2051|Compound:5263410|FD-Score:4.45|P-value:6.80E-6 ID:SGTC_2058|Compound:5236698|FD-Score:4.27|P-value:1.50E-5 ID:SGTC_2105|Compound:5350118|FD-Score:-3.60|P-value:2.26E-4 ID:SGTC_2106|Compound:5357045|FD-Score:4.00|P-value:4.60E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.62|P-value:2.09E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.89|P-value:8.76E-7 ID:SGTC_2282|Compound:7944268|FD-Score:3.92|P-value:6.38E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.81|P-value:9.63E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.70|P-value:1.18E-53 ID:SGTC_2584|Compound:androsterone|FD-Score:3.98|P-value:4.95E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.53|P-value:2.73E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.84|P-value:9.13E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.74|P-value:1.01E-8 ID:SGTC_2858|Compound:9025781|FD-Score:3.95|P-value:5.54E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.90|P-value:6.88E-5 ID:SGTC_3227|Compound:9130768|FD-Score:3.99|P-value:4.73E-5 ID:SGTC_3304|Compound:9125678|FD-Score:4.01|P-value:4.47E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.41|P-value:4.20E-4

Top fitness defect scores for YCR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 15.70 100.0 µM 1.18E-53 redox potentiating 10 3.75E-56
2 SGTC_36 0335-0881 11.80 14.2 µM 6.59E-31 ubiquinone biosynthesis & proteasome 17 2.68E-32
3 SGTC_178 4092-0806 9.40 87.5 µM 2.05E-20 ergosterol depletion effects on membrane 12 2.68E-21
4 SGTC_1317 1273-0028 8.48 910.0 nM 5.92E-17 azole & statin 15 1.13E-17
5 SGTC_158 k038-0087 7.39 26.4 µM 2.62E-13 ubiquinone biosynthesis & proteasome 53 7.50E-14
6 SGTC_279 1273-0055 6.77 2.9 µM 1.79E-11 azole & statin 7 6.27E-12
7 SGTC_418 lividomycin a 6.42 100.0 µM 1.70E-10 2 6.62E-11
8 SGTC_2833 9001315 5.74 45.5 µM 1.01E-8 amide catabolism 21 4.75E-9
9 SGTC_628 1636-0253 5.17 16.0 µM 2.17E-7 sphingolipid biosynthesis & PDR1 14 1.18E-7
10 SGTC_2250 alverine citrate 4.89 130.0 µM 8.76E-7 97 5.08E-7
11 SGTC_1941 st076221 4.87 61.8 µM 9.68E-7 sphingolipid biosynthesis & PDR1 51 5.63E-7
12 SGTC_142 0335-0849 4.77 62.7 µM 1.56E-6 ubiquinone biosynthesis & proteasome 92 9.28E-7
13 SGTC_1172 0370-0043 4.66 85.0 µM 2.55E-6 8 1.55E-6
14 SGTC_616 4092-0450 4.66 108.0 µM 2.63E-6 4 1.60E-6
15 SGTC_358 0075-0058 4.51 9.4 µM 5.23E-6 41 3.29E-6
16 SGTC_2051 5263410 4.45 176.0 µM 6.80E-6 13 4.33E-6
17 SGTC_1718 roemerine 4.43 11.9 µM 7.46E-6 redox potentiating 34 4.77E-6
18 SGTC_2058 5236698 4.27 133.0 µM 1.50E-5 22 9.90E-6
19 SGTC_146 3448-8650 4.22 53.1 µM 1.83E-5 NEO1-PIK1 121 1.22E-5
20 SGTC_1483 3453-0561 4.15 55.9 µM 2.49E-5 18 1.68E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 8.23E-100 YKR029C SET3 hom Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
0.318 1.48E-79 YGL194C HOS2 hom Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
0.313 5.87E-77 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.297 2.45E-69 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.288 3.80E-65 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.286 3.72E-64 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.264 1.59E-54 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.251 3.27E-49 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.248 3.91E-48 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.236 1.03E-43 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.231 8.74E-42 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.228 7.49E-41 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.223 4.12E-39 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.223 5.18E-39 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.223 7.00E-39 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data