YCR034W / FEN1

Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR034W / FEN1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:4.03|P-value:1.45E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.61|P-value:6.35E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.33|P-value:2.67E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:4.34|P-value:4.29E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:4.44|P-value:2.76E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.07|P-value:1.24E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.53|P-value:9.26E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.67|P-value:1.04E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:5.95|P-value:1.93E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.51|P-value:1.02E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.79|P-value:6.24E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.16|P-value:3.65E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.02|P-value:2.17E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.32|P-value:2.03E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.12|P-value:1.01E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.66|P-value:1.13E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.08|P-value:1.19E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.97|P-value:2.77E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.74|P-value:4.08E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.80|P-value:3.36E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:4.16|P-value:8.79E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:5.02|P-value:2.22E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.08|P-value:1.18E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.52|P-value:8.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.58|P-value:7.56E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.19|P-value:7.69E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.13|P-value:9.82E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.65|P-value:1.13E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.37|P-value:4.05E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.87|P-value:4.26E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:5.20|P-value:9.47E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.17|P-value:8.33E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.75|P-value:4.02E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.86|P-value:3.16E-8 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.82|P-value:3.06E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.53|P-value:8.49E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:7.33|P-value:3.87E-12 ID:SGTC_1623|Compound:st003709|FD-Score:4.53|P-value:1.89E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.86|P-value:2.71E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.08|P-value:1.68E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.61|P-value:1.37E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-2.88|P-value:9.61E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.56|P-value:7.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.22|P-value:6.75E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.99|P-value:2.50E-6 ID:SGTC_2007|Compound:4011539|FD-Score:3.83|P-value:2.98E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.71|P-value:8.99E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-2.94|P-value:7.74E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.71|P-value:4.52E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.37|P-value:3.79E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.56|P-value:1.66E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.74|P-value:4.12E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.91|P-value:2.37E-8 ID:SGTC_2485|Compound:5633444|FD-Score:3.81|P-value:3.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.72|P-value:4.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.71|P-value:7.09E-8 ID:SGTC_2712|Compound:st079126|FD-Score:5.80|P-value:4.24E-8 ID:SGTC_2740|Compound:felodipine|FD-Score:4.57|P-value:1.62E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.13|P-value:9.84E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.97|P-value:1.37E-7 ID:SGTC_3008|Compound:9078912|FD-Score:3.97|P-value:1.76E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.89|P-value:9.28E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.55|P-value:7.95E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.80|P-value:3.37E-4 ID:SGTC_3214|Compound:9129694|FD-Score:7.03|P-value:2.77E-11 ID:SGTC_3219|Compound:9131112|FD-Score:4.65|P-value:1.13E-5 ID:SGTC_3223|Compound:9129970|FD-Score:5.20|P-value:9.43E-7 ID:SGTC_3236|Compound:9132701|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.80|P-value:3.36E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.72|P-value:4.33E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:4.03|P-value:1.45E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.61|P-value:6.35E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.33|P-value:2.67E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:4.34|P-value:4.29E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:4.44|P-value:2.76E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.07|P-value:1.24E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.53|P-value:9.26E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:4.67|P-value:1.04E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:5.95|P-value:1.93E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.51|P-value:1.02E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.79|P-value:6.24E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.16|P-value:3.65E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.02|P-value:2.17E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.32|P-value:2.03E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.12|P-value:1.01E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.66|P-value:1.13E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:4.08|P-value:1.19E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.97|P-value:2.77E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.29|P-value:2.27E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.74|P-value:4.08E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.80|P-value:3.36E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:4.16|P-value:8.79E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:5.02|P-value:2.22E-6 ID:SGTC_884|Compound:0851-0618|FD-Score:4.08|P-value:1.18E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.52|P-value:8.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.58|P-value:7.56E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.19|P-value:7.69E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.13|P-value:9.82E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:4.65|P-value:1.13E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.37|P-value:4.05E-7 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.87|P-value:4.26E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:5.20|P-value:9.47E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.17|P-value:8.33E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.75|P-value:4.02E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:5.86|P-value:3.16E-8 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.82|P-value:3.06E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.53|P-value:8.49E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:7.33|P-value:3.87E-12 ID:SGTC_1623|Compound:st003709|FD-Score:4.53|P-value:1.89E-5 ID:SGTC_1687|Compound:st020778|FD-Score:3.86|P-value:2.71E-4 ID:SGTC_1728|Compound:st035614|FD-Score:5.08|P-value:1.68E-6 ID:SGTC_1782|Compound:st039423|FD-Score:4.61|P-value:1.37E-5 ID:SGTC_1861|Compound:st057647|FD-Score:-2.88|P-value:9.61E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.56|P-value:7.67E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.22|P-value:6.75E-5 ID:SGTC_1974|Compound:st069448|FD-Score:4.99|P-value:2.50E-6 ID:SGTC_2007|Compound:4011539|FD-Score:3.83|P-value:2.98E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.71|P-value:8.99E-6 ID:SGTC_2125|Compound:5246583|FD-Score:-2.94|P-value:7.74E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.71|P-value:4.52E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.37|P-value:3.79E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.56|P-value:1.66E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.74|P-value:4.12E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.91|P-value:2.37E-8 ID:SGTC_2485|Compound:5633444|FD-Score:3.81|P-value:3.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.72|P-value:4.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.71|P-value:7.09E-8 ID:SGTC_2712|Compound:st079126|FD-Score:5.80|P-value:4.24E-8 ID:SGTC_2740|Compound:felodipine|FD-Score:4.57|P-value:1.62E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.13|P-value:9.84E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.97|P-value:1.37E-7 ID:SGTC_3008|Compound:9078912|FD-Score:3.97|P-value:1.76E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.89|P-value:9.28E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.55|P-value:7.95E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.80|P-value:3.37E-4 ID:SGTC_3214|Compound:9129694|FD-Score:7.03|P-value:2.77E-11 ID:SGTC_3219|Compound:9131112|FD-Score:4.65|P-value:1.13E-5 ID:SGTC_3223|Compound:9129970|FD-Score:5.20|P-value:9.43E-7 ID:SGTC_3236|Compound:9132701|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.80|P-value:3.36E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.72|P-value:4.33E-4

Top fitness defect scores for YCR034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_69 0096-0274 8.33 206.7 µM 2.67E-15 mitochondrial processes 2 4.03E-17
2 SGTC_1568 digitonin 7.33 820.0 nM 3.87E-12 sphingolipid biosynthesis & PDR1 9 1.16E-13
3 SGTC_3214 9129694 7.03 49.5 µM 2.77E-11 2 1.00E-12
4 SGTC_196 k015-0023 5.95 18.1 µM 1.93E-8 PDR1 4 1.36E-9
5 SGTC_2482 5981709 5.91 142.7 µM 2.37E-8 PDR1 11 1.71E-9
6 SGTC_1453 4237-0541 5.86 195.0 µM 3.16E-8 heme biosynthesis & mitochondrial translocase 5 2.35E-9
7 SGTC_2712 st079126 5.80 47.7 µM 4.24E-8 1 3.25E-9
8 SGTC_2701 st077767 5.71 14.7 µM 7.09E-8 16 5.74E-9
9 SGTC_1013 4112-3890 5.37 241.0 µM 4.05E-7 TSC3-RPN4 10 3.97E-8
10 SGTC_3223 9129970 5.20 49.5 µM 9.43E-7 5 1.02E-7
11 SGTC_1068 loratadine 5.20 26.9 µM 9.47E-7 9 1.02E-7
12 SGTC_1728 st035614 5.08 33.8 µM 1.68E-6 19 1.93E-7
13 SGTC_366 0181-0206 5.02 4.3 µM 2.17E-6 Golgi 16 2.57E-7
14 SGTC_724 3910-0327 5.02 137.0 µM 2.22E-6 ERG2 9 2.64E-7
15 SGTC_1974 st069448 4.99 26.9 µM 2.50E-6 9 3.01E-7
16 SGTC_545 4218-0007 4.97 221.0 µM 2.77E-6 11 3.38E-7
17 SGTC_1015 4130-4525 4.87 82.0 µM 4.26E-6 60S ribosome export 9 5.46E-7
18 SGTC_275 trichlorophene 4.79 5.7 µM 6.24E-6 mitochondrial stress 184 8.35E-7
19 SGTC_2053 5265679 4.71 138.0 µM 8.99E-6 8 1.26E-6
20 SGTC_194 1486-1323 4.67 56.9 µM 1.04E-5 9 1.47E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.21E-26 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.172 7.97E-24 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.167 2.47E-22 YLR372W SUR4 hom Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
0.161 5.85E-21 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.147 1.36E-17 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.142 1.07E-16 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.138 1.18E-15 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
0.137 2.09E-15 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.130 3.32E-14 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.124 5.65E-13 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.124 6.82E-13 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.116 1.57E-11 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.115 2.44E-11 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.59E-11 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.115 2.69E-11 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication