YCR037C / PHO87

Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR037C / PHO87

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:3.81|P-value:6.31E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.96|P-value:3.37E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.60|P-value:1.27E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.06|P-value:9.06E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.52|P-value:1.36E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:5.13|P-value:1.20E-7 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.47|P-value:2.07E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.12|P-value:7.56E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.36|P-value:3.12E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.65|P-value:1.47E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.83|P-value:5.73E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:4.07|P-value:2.10E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.72|P-value:9.29E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.43|P-value:2.83E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.15|P-value:1.49E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.35|P-value:3.90E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.20|P-value:6.48E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.73|P-value:9.03E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.12|P-value:8.69E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.14|P-value:1.59E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.59|P-value:1.98E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:7.33|P-value:7.60E-14 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.81|P-value:5.30E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:9.90E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.19|P-value:1.24E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-8.26|P-value:2.79E-17 ID:SGTC_1729|Compound:st035615|FD-Score:5.36|P-value:3.42E-8 ID:SGTC_1746|Compound:st038117|FD-Score:3.59|P-value:1.53E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.24|P-value:5.62E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.60|P-value:1.81E-6 ID:SGTC_1950|Compound:st077106|FD-Score:4.97|P-value:2.77E-7 ID:SGTC_2069|Compound:5228469|FD-Score:3.73|P-value:8.85E-5 ID:SGTC_2104|Compound:5389443|FD-Score:6.90|P-value:1.77E-12 ID:SGTC_2121|Compound:5257820|FD-Score:3.18|P-value:7.16E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.25|P-value:5.58E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.25|P-value:5.49E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.85|P-value:5.51E-5 ID:SGTC_2243|Compound:6634756|FD-Score:6.26|P-value:1.39E-10 ID:SGTC_2247|Compound:cerulenin|FD-Score:7.19|P-value:2.10E-13 ID:SGTC_2256|Compound:7954252|FD-Score:6.21|P-value:1.92E-10 ID:SGTC_2340|Compound:7987427|FD-Score:3.61|P-value:1.46E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.08|P-value:2.01E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.06|P-value:9.30E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.07|P-value:1.63E-7 ID:SGTC_2887|Compound:9044784|FD-Score:3.25|P-value:5.53E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.14|P-value:6.96E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.71|P-value:8.16E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.51|P-value:2.79E-6 ID:SGTC_3007|Compound:9078383|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.23|P-value:6.01E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.91|P-value:4.29E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.36|P-value:5.72E-6 ID:SGTC_80|Compound:0159-0065|FD-Score:3.81|P-value:6.31E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.96|P-value:3.37E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.60|P-value:1.27E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.06|P-value:9.06E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.52|P-value:1.36E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:5.13|P-value:1.20E-7 ID:SGTC_295|Compound:k015-0027|FD-Score:-3.47|P-value:2.07E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.12|P-value:7.56E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.36|P-value:3.12E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.65|P-value:1.47E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:3.36|P-value:3.68E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.83|P-value:5.73E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:4.07|P-value:2.10E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.72|P-value:9.29E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.43|P-value:2.83E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:4.15|P-value:1.49E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.35|P-value:3.90E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.20|P-value:1.20E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.20|P-value:6.48E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.73|P-value:9.03E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.12|P-value:8.69E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.14|P-value:1.59E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.59|P-value:1.98E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:7.33|P-value:7.60E-14 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.81|P-value:5.30E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:9.90E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:4.19|P-value:1.24E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-8.26|P-value:2.79E-17 ID:SGTC_1729|Compound:st035615|FD-Score:5.36|P-value:3.42E-8 ID:SGTC_1746|Compound:st038117|FD-Score:3.59|P-value:1.53E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.24|P-value:5.62E-4 ID:SGTC_1896|Compound:st058441|FD-Score:4.60|P-value:1.81E-6 ID:SGTC_1950|Compound:st077106|FD-Score:4.97|P-value:2.77E-7 ID:SGTC_2069|Compound:5228469|FD-Score:3.73|P-value:8.85E-5 ID:SGTC_2104|Compound:5389443|FD-Score:6.90|P-value:1.77E-12 ID:SGTC_2121|Compound:5257820|FD-Score:3.18|P-value:7.16E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.25|P-value:5.58E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_2218|Compound:6965428|FD-Score:3.25|P-value:5.49E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.85|P-value:5.51E-5 ID:SGTC_2243|Compound:6634756|FD-Score:6.26|P-value:1.39E-10 ID:SGTC_2247|Compound:cerulenin|FD-Score:7.19|P-value:2.10E-13 ID:SGTC_2256|Compound:7954252|FD-Score:6.21|P-value:1.92E-10 ID:SGTC_2340|Compound:7987427|FD-Score:3.61|P-value:1.46E-4 ID:SGTC_2623|Compound:humulene|FD-Score:4.08|P-value:2.01E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-3.06|P-value:9.30E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.07|P-value:1.63E-7 ID:SGTC_2887|Compound:9044784|FD-Score:3.25|P-value:5.53E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.14|P-value:6.96E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.71|P-value:8.16E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_3000|Compound:9075062|FD-Score:4.51|P-value:2.79E-6 ID:SGTC_3007|Compound:9078383|FD-Score:-3.24|P-value:4.95E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.23|P-value:6.01E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.91|P-value:4.29E-5 ID:SGTC_3224|Compound:9130643|FD-Score:4.36|P-value:5.72E-6

Top fitness defect scores for YCR037C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1365 1672-3266 7.33 55.4 µM 7.60E-14 1 1.18E-13
2 SGTC_2247 cerulenin 7.19 830.0 nM 2.10E-13 3 3.19E-13
3 SGTC_2104 5389443 6.90 200.0 µM 1.77E-12 3 2.58E-12
4 SGTC_2243 6634756 6.26 200.0 µM 1.39E-10 2 1.87E-10
5 SGTC_2256 7954252 6.21 200.0 µM 1.92E-10 mitochondrial processes 1 2.58E-10
6 SGTC_166 k072-0058 5.52 166.4 µM 1.36E-8 DNA intercalators 8 1.69E-8
7 SGTC_1729 st035615 5.36 46.0 µM 3.42E-8 11 4.19E-8
8 SGTC_208 k072-0098 5.13 12.4 µM 1.20E-7 heme biosynthesis & mitochondrial translocase 24 1.44E-7
9 SGTC_2837 9008476 5.07 45.5 µM 1.63E-7 12 1.95E-7
10 SGTC_1950 st077106 4.97 7.2 µM 2.77E-7 RNA processing & uracil transport 12 3.27E-7
11 SGTC_773 4358-1457 4.83 44.6 µM 5.73E-7 24 6.70E-7
12 SGTC_464 bw-b 70c 4.65 158.0 µM 1.47E-6 9 1.69E-6
13 SGTC_1896 st058441 4.60 89.0 µM 1.81E-6 5 2.07E-6
14 SGTC_1246 0422-0085 4.59 105.0 µM 1.98E-6 14 2.26E-6
15 SGTC_3000 9075062 4.51 71.4 µM 2.79E-6 9 3.18E-6
16 SGTC_3224 9130643 4.36 49.5 µM 5.72E-6 RPP1 & pyrimidine depletion 18 6.43E-6
17 SGTC_1041 0206-0046 4.20 107.0 µM 1.20E-5 26 1.33E-5
18 SGTC_1540 guanosine 4.19 70.6 µM 1.24E-5 4 1.38E-5
19 SGTC_997 3996-0078 4.15 137.0 µM 1.49E-5 17 1.65E-5
20 SGTC_1225 1216-0074 4.14 20.6 µM 1.59E-5 20 1.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.06E-9 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.093 6.59E-8 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.080 4.04E-6 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.072 3.10E-5 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.070 4.61E-5 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070 4.89E-5 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
0.070 5.52E-5 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.069 5.90E-5 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.069 6.33E-5 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.069 6.87E-5 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.069 6.77E-5 YHR070W TRM5 het tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
0.069 7.04E-5 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.067 1.03E-4 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.067 1.16E-4 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.064 2.02E-4 YNL116W DMA2 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains