YCR043C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR043C / YCR043C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:12.20|P-value:5.53E-31 ID:SGTC_252|Compound:miconazole|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.72|P-value:3.79E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:5.60|P-value:7.06E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.34|P-value:2.27E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.31|P-value:9.25E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.48|P-value:5.31E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.96|P-value:9.92E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:5.67|P-value:4.84E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:3.64|P-value:3.13E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.74|P-value:2.21E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.46|P-value:1.39E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.87|P-value:1.40E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.62|P-value:3.30E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.84|P-value:1.54E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.28|P-value:2.88E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.14|P-value:4.96E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.59|P-value:3.67E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.34|P-value:8.58E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.40|P-value:7.11E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:9.54E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.74|P-value:2.18E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.03|P-value:7.52E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.09|P-value:6.18E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.83|P-value:1.55E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.44|P-value:6.08E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.59|P-value:3.75E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.81|P-value:3.04E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.44|P-value:1.60E-7 ID:SGTC_2698|Compound:st077697|FD-Score:3.97|P-value:9.62E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.38|P-value:7.48E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.23|P-value:3.49E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.22|P-value:4.69E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.30|P-value:9.79E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.62|P-value:7.15E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.93|P-value:1.10E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-4.02|P-value:7.89E-5 ID:SGTC_2991|Compound:9074669|FD-Score:5.35|P-value:2.51E-7 ID:SGTC_3010|Compound:9080089|FD-Score:4.40|P-value:1.78E-5 ID:SGTC_3014|Compound:9081533|FD-Score:-3.65|P-value:3.02E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:9.16E-4 ID:SGTC_3097|Compound:9117246|FD-Score:4.22|P-value:3.61E-5 ID:SGTC_3101|Compound:9120531|FD-Score:5.25|P-value:4.00E-7 ID:SGTC_3210|Compound:9128157|FD-Score:3.56|P-value:4.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.74|P-value:2.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:12.20|P-value:5.53E-31 ID:SGTC_252|Compound:miconazole|FD-Score:3.40|P-value:6.95E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.72|P-value:3.79E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:5.60|P-value:7.06E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.34|P-value:2.27E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.60|P-value:3.57E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.31|P-value:9.25E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:3.48|P-value:5.31E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.96|P-value:9.92E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:5.67|P-value:4.84E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:3.64|P-value:3.13E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.74|P-value:2.21E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.46|P-value:1.39E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.53|P-value:4.60E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.64|P-value:3.09E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.87|P-value:1.40E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.62|P-value:3.30E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.41|P-value:6.73E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.84|P-value:1.54E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.28|P-value:2.88E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_1711|Compound:st032263|FD-Score:4.14|P-value:4.96E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.59|P-value:3.67E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.34|P-value:8.58E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.40|P-value:7.11E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.30|P-value:9.54E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.74|P-value:2.18E-4 ID:SGTC_2294|Compound:7971431|FD-Score:4.03|P-value:7.52E-5 ID:SGTC_2299|Compound:7976368|FD-Score:4.09|P-value:6.18E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.83|P-value:1.55E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.44|P-value:6.08E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.59|P-value:3.75E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.81|P-value:3.04E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.44|P-value:1.60E-7 ID:SGTC_2698|Compound:st077697|FD-Score:3.97|P-value:9.62E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.38|P-value:7.48E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.23|P-value:3.49E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.22|P-value:4.69E-7 ID:SGTC_2869|Compound:9037858|FD-Score:3.30|P-value:9.79E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.62|P-value:7.15E-6 ID:SGTC_2921|Compound:7974240|FD-Score:3.93|P-value:1.10E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-4.02|P-value:7.89E-5 ID:SGTC_2991|Compound:9074669|FD-Score:5.35|P-value:2.51E-7 ID:SGTC_3010|Compound:9080089|FD-Score:4.40|P-value:1.78E-5 ID:SGTC_3014|Compound:9081533|FD-Score:-3.65|P-value:3.02E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:9.16E-4 ID:SGTC_3097|Compound:9117246|FD-Score:4.22|P-value:3.61E-5 ID:SGTC_3101|Compound:9120531|FD-Score:5.25|P-value:4.00E-7 ID:SGTC_3210|Compound:9128157|FD-Score:3.56|P-value:4.11E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.74|P-value:2.18E-4

Top fitness defect scores for YCR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.20 9.0 µM 5.53E-31 cell wall 51 8.48E-35
2 SGTC_360 0957-0399 5.72 1.0 µM 3.79E-8 cell wall 15 5.30E-9
3 SGTC_853 0419-0306 5.67 21.0 µM 4.84E-8 1 6.98E-9
4 SGTC_361 000s-0510 5.60 1.4 µM 7.06E-8 5 1.07E-8
5 SGTC_2612 dictamnine 5.44 15.5 µM 1.60E-7 RNA pol III & RNase P/MRP 18 2.68E-8
6 SGTC_2991 9074669 5.35 71.4 µM 2.51E-7 azole & statin 25 4.47E-8
7 SGTC_3101 9120531 5.25 49.5 µM 4.00E-7 11 7.55E-8
8 SGTC_2842 9000675 5.22 19.5 µM 4.69E-7 5 9.04E-8
9 SGTC_2438 5259590 4.81 200.0 µM 3.04E-6 8 7.43E-7
10 SGTC_2908 7930301 4.62 100.0 µM 7.15E-6 12 1.94E-6
11 SGTC_999 4022-0066 4.46 22.7 µM 1.39E-5 Golgi 29 4.12E-6
12 SGTC_3010 9080089 4.40 71.4 µM 1.78E-5 8 5.43E-6
13 SGTC_387 norethindrone acetate 4.34 66.7 µM 2.27E-5 5 7.14E-6
14 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.28 90.6 µM 2.88E-5 25 9.33E-6
15 SGTC_2836 9010338 4.23 19.5 µM 3.49E-5 RPP1 & pyrimidine depletion 19 1.16E-5
16 SGTC_3097 9117246 4.22 49.5 µM 3.61E-5 6 1.20E-5
17 SGTC_1711 st032263 4.14 62.8 µM 4.96E-5 14 1.72E-5
18 SGTC_2299 7976368 4.09 114.9 µM 6.18E-5 28 2.20E-5
19 SGTC_2294 7971431 4.03 200.0 µM 7.52E-5 12 2.75E-5
20 SGTC_2698 st077697 3.97 67.5 µM 9.62E-5 16 3.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 2.23E-50 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.237 5.14E-44 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.214 4.75E-36 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.213 6.55E-36 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.208 3.06E-34 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.205 4.72E-33 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.198 5.27E-31 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.195 4.39E-30 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.195 5.51E-30 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.194 6.03E-30 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.192 2.94E-29 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.184 4.87E-27 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.183 1.50E-26 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.176 1.01E-24 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.174 3.30E-24 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress