YCR044C / PER1

Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR044C / PER1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.49|P-value:6.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.43|P-value:1.32E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.09|P-value:6.85E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.14|P-value:1.03E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.28|P-value:2.46E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:5.10|P-value:1.13E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:5.48|P-value:3.61E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:8.98E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.06|P-value:7.51E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.71|P-value:1.25E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.39|P-value:8.14E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.88|P-value:2.15E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.38|P-value:8.21E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.88|P-value:2.16E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-5.42|P-value:1.38E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:7.50|P-value:2.12E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.14|P-value:4.07E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.54|P-value:5.44E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.25|P-value:7.42E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.84|P-value:1.13E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.33|P-value:9.41E-4 ID:SGTC_1519|Compound:esterone|FD-Score:6.35|P-value:1.88E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-4.46|P-value:2.56E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.65|P-value:4.11E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-4.24|P-value:4.62E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.70|P-value:3.57E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.25|P-value:7.29E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-4.48|P-value:2.40E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.33|P-value:9.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:-4.05|P-value:7.70E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.28|P-value:4.15E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.86|P-value:8.11E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.78|P-value:2.83E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.77|P-value:2.97E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.52|P-value:5.71E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.76|P-value:1.45E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.40|P-value:7.88E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.31|P-value:9.87E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-4.05|P-value:7.75E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.41|P-value:7.74E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:5.30|P-value:6.22E-5 ID:SGTC_2792|Compound:7535235|FD-Score:4.33|P-value:9.30E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.64|P-value:4.14E-4 ID:SGTC_2824|Compound:7998404|FD-Score:6.75|P-value:4.27E-7 ID:SGTC_2825|Compound:7998094|FD-Score:11.00|P-value:2.09E-16 ID:SGTC_2834|Compound:9001755|FD-Score:-3.95|P-value:9.93E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.08|P-value:1.22E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.53|P-value:5.68E-4 ID:SGTC_3211|Compound:9128781|FD-Score:9.81|P-value:2.78E-13 ID:SGTC_3266|Compound:9136860|FD-Score:-4.45|P-value:2.65E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.92|P-value:8.50E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.79|P-value:1.32E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.60|P-value:4.63E-4 ID:SGTC_3324|Compound:9138759|FD-Score:6.60|P-value:7.60E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:4.49|P-value:6.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.43|P-value:1.32E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.09|P-value:6.85E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:5.14|P-value:1.03E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.28|P-value:2.46E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:5.10|P-value:1.13E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:5.48|P-value:3.61E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.99|P-value:8.98E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.06|P-value:7.51E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.71|P-value:1.25E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.39|P-value:8.14E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.88|P-value:2.15E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.38|P-value:8.21E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.88|P-value:2.16E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-5.42|P-value:1.38E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:7.50|P-value:2.12E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:6.14|P-value:4.07E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.54|P-value:5.44E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.25|P-value:7.42E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.84|P-value:1.13E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.33|P-value:9.41E-4 ID:SGTC_1519|Compound:esterone|FD-Score:6.35|P-value:1.88E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-4.46|P-value:2.56E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.65|P-value:4.11E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:-4.24|P-value:4.62E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.70|P-value:3.57E-4 ID:SGTC_1959|Compound:st077091|FD-Score:5.25|P-value:7.29E-5 ID:SGTC_2083|Compound:5306046|FD-Score:-4.48|P-value:2.40E-4 ID:SGTC_2087|Compound:5276107|FD-Score:4.33|P-value:9.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:-4.05|P-value:7.70E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.28|P-value:4.15E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.86|P-value:8.11E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.78|P-value:2.83E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.77|P-value:2.97E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:4.52|P-value:5.71E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.76|P-value:1.45E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.40|P-value:7.88E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.31|P-value:9.87E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-4.05|P-value:7.75E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.41|P-value:7.74E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:5.30|P-value:6.22E-5 ID:SGTC_2792|Compound:7535235|FD-Score:4.33|P-value:9.30E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.64|P-value:4.14E-4 ID:SGTC_2824|Compound:7998404|FD-Score:6.75|P-value:4.27E-7 ID:SGTC_2825|Compound:7998094|FD-Score:11.00|P-value:2.09E-16 ID:SGTC_2834|Compound:9001755|FD-Score:-3.95|P-value:9.93E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.08|P-value:1.22E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.53|P-value:5.68E-4 ID:SGTC_3211|Compound:9128781|FD-Score:9.81|P-value:2.78E-13 ID:SGTC_3266|Compound:9136860|FD-Score:-4.45|P-value:2.65E-4 ID:SGTC_3303|Compound:9125618|FD-Score:5.92|P-value:8.50E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.79|P-value:1.32E-5 ID:SGTC_3307|Compound:9126885|FD-Score:4.60|P-value:4.63E-4 ID:SGTC_3324|Compound:9138759|FD-Score:6.60|P-value:7.60E-7

Top fitness defect scores for YCR044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2825 7998094 11.00 58.4 µM 2.09E-16 fatty acid desaturase (OLE1) 2 1.22E-28
2 SGTC_3211 9128781 9.81 49.5 µM 2.78E-13 7 5.20E-23
3 SGTC_1039 k821-0043 7.50 94.0 µM 2.12E-8 Golgi 3 3.24E-14
4 SGTC_2824 7998404 6.75 52.0 µM 4.27E-7 4 7.26E-12
5 SGTC_3324 9138759 6.60 60.8 µM 7.60E-7 1 2.05E-11
6 SGTC_1519 esterone 6.35 74.0 µM 1.88E-6 DNA intercalators 3 1.05E-10
7 SGTC_240 5hr heat shock (37°C) + Streptovitacin 6.28 300.0 µM 2.46E-6 heat shock/prefoldin 14 1.70E-10
8 SGTC_1119 parthenolide 6.14 318.5 nM 4.07E-6 TSC3-RPN4 9 4.21E-10
9 SGTC_3303 9125618 5.92 40.6 µM 8.50E-6 14 1.58E-9
10 SGTC_1377 2944-0135 5.84 198.0 µM 1.13E-5 calcium & mitochondrial duress 13 2.63E-9
11 SGTC_3304 9125678 5.79 46.1 µM 1.32E-5 14 3.51E-9
12 SGTC_2603 homopterocarpin 5.76 100.0 µM 1.45E-5 8 4.11E-9
13 SGTC_405 ebelactone b 5.48 50.0 µM 3.61E-5 2 2.14E-8
14 SGTC_2777 climbazole 5.30 1.5 µM 6.22E-5 iron homeostasis 17 5.67E-8
15 SGTC_1959 st077091 5.25 55.8 µM 7.29E-5 RPP1 & pyrimidine depletion 16 7.56E-8
16 SGTC_1263 0774-1208 5.25 64.8 µM 7.42E-5 17 7.79E-8
17 SGTC_206 4546-0025 5.14 72.0 µM 1.03E-4 NEO1 38 1.41E-7
18 SGTC_368 fentichlor 5.10 4.6 µM 1.13E-4 9 1.66E-7
19 SGTC_2835 9006588 5.08 71.4 µM 1.22E-4 17 1.92E-7
20 SGTC_622 1348-1566 4.88 26.3 µM 2.15E-4 9 5.25E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.44E-11 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.107 4.66E-10 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.107 5.30E-10 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.105 9.59E-10 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.098 1.21E-8 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.096 2.33E-8 YNL139C THO2 hom Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
0.096 3.00E-8 YDR524C-B_p YDR524C-B_p hom Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication
0.094 5.00E-8 YBR116C_d YBR116C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
0.092 9.08E-8 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.091 1.28E-7 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.090 1.83E-7 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.090 2.07E-7 YAL012W CYS3 hom Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress
0.090 2.03E-7 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.089 3.01E-7 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.087 5.19E-7 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine